412 Outcomes of robot-assisted partial nephrectomy in patients with complex renal tumours and pre-existing chronic kidney disease in a multi-institutional, multinational database

Dalela, Deepansh; Barod, Ravi; Gandaglia, Giorgio; Abaza, Ronney; Adshead, James; Ahlawat, Rajesh; Buffi, N.; Challacombe, Ben; Dasgupta, P.; Moon, Daniel; Parekh, Dipen J.; Porpiglia, F.; Rawal, Sushil Bahadur; Novara, Giacomo; Bhandari, Mohit; Rogers, C.G.; Mottrie, Alexander

doi:10.1016/s1569-9056(16)60414-1

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“…[9] conducted a propensity‐score‐matched analysis of outcomes of RAPN vs OPN in a small group of patients with CKD (40 patients in each group) and reported comparable outcomes in terms of renal function preservation and rate of peri‐operative complications. Similarly positive peri‐operative and functional outcomes have been reported in RAPN for small renal masses in patients with CKD [23,24] as well as when comparing outcomes between RAPN and OPN in the setting of solitary kidneys [10].…”

Section: Discussionmentioning

confidence: 78%

Outcomes in robot‐assisted partial nephrectomy for imperative vs elective indications

et al. 2021

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Objectives To assess and compare peri‐operative outcomes of patients undergoing robot‐assisted partial nephrectomy (RAPN) for imperative vs elective indications. Patient and Methods We retrospectively reviewed a multinational database of 3802 adults who underwent RAPN for elective and imperative indications. Laparoscopic or open partial nephrectomy (PN) were excluded. Baseline data for age, gender, body mass index, American Society of Anaesthesiologists score and PADUA score were examined. Patients undergoing RAPN for an imperative indication were matched to those having surgery for an elective indication using propensity scores in a 1:3 ratio. Primary outcomes included organ ischaemic time, operating time, estimated blood loss (EBL), rate of blood transfusions, Clavien–Dindo complications, conversion to radical nephrectomy (RN) and positive surgical margin (PSM) status. Results After propensity‐score matching for baseline variables, a total of 304 patients (76 imperative vs 228 elective indications) were included in the final analysis. No significant differences were found between groups for ischaemia time (19.9 vs 19.8 min; P = 0.94), operating time (186 vs 180 min; P = 0.55), EBL (217 vs 190 mL; P = 0.43), rate of blood transfusions (2.7% vs 3.7%; P = 0.51), or Clavien–Dindo complications (P = 0.31). A 38.6% (SD 47.9) decrease in Day‐1 postoperative estimated glomerular filtration rate was observed in the imperative indication group and an 11.3% (SD 45.1) decrease was observed in the elective indication group (P < 0.005). There were no recorded cases of permanent or temporary dialysis. There were no conversions to RN in the imperative group, and seven conversions (5.6%) in the elective group (P = 0.69). PSMs were seen in 1.4% (1/76) of the imperative group and in 3.3% of the elective group (7/228; P = 0.69). Conclusion We conclude that RAPN is feasible and safe for imperative indications and demonstrates similar outcomes to those achieved for elective indications.

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Section: Discussionmentioning

confidence: 78%