419 Role of second-trimester plasma microRNA-210 levels in prediction of preeclampsia: prospective cohort study

Abbas, Ahmed M.; Mammdoh, Yousra M.; El-Moneum, Omnia Abd; Omer, Hanan; El-Din, Lubna Tag

doi:10.1016/j.ajog.2020.12.440

Cited by 3 publications

(1 citation statement)

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“…Subsequently, we assessed the full texts of the remaining 48 articles and excluded 34 studies based on the exclusion criteria, including 7 not studies on circulating ncRNAs, 8 without clinical data to make a 2 × 2 contingency table and 8 studies that used ncRNAs for diagnosis. In total, 14 studies were ultimately included in this study [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The selection process ow chart of our study is presented in Fig.…”

Section: Literature Searchmentioning

confidence: 99%

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: A diagnostic meta-analysis

Yang

Zhong

et al. 2021

Preprint

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Background We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia. Methods PubMed, Embase and the Cochrane Library were used to search for literature. The combined prediction performance was evaluated by calculating the area under the summary receiver operator characteristic (SROC) curve. The potential sources of heterogeneity were analysed by meta-regression analysis and subgroup analysis. All statistical analyses and mapping were performed by RevMan 5.3 and Stata 12.0. Results A total of 41 studies from 14 articles, including 557 preeclampsia patients and 842 controls, were included in our meta-analysis. All studies collected blood before onset. NcRNAs in blood performed relatively well in predicting preeclampsia. The combined sensitivity was 0.71, the specificity was 0.84, and the area under the SROC curve (AUC) was 0.86. Peripheral blood mononuclear cells (PBMC) samples showed the best diagnostic accuracy. The combined AUC was 0.93. Combined detection was better than single detection, and miRNA was better than circRNA. The heterogeneity of the study was determined by sample size, lncRNA characteristics, lncRNA source and race. Conclusion Circulating ncRNAs can be used as noninvasive early predictive biomarkers of preeclampsia and have great clinical application prospects. Its clinical value needs to be tested by further multicentre, comprehensive and prospective studies, and the test criteria should be established.

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Section: Literature Searchmentioning

confidence: 99%

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: A diagnostic meta-analysis

Yang

Zhong

et al. 2021

Preprint

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Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis

Yang

Zhong

et al. 2021

Reprod Biol Endocrinol

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Background We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia. Methods PubMed, Embase and the Cochrane Library were used to search for literature. The combined prediction performance was evaluated by calculating the area under the summary receiver operator characteristic (SROC) curve. The potential sources of heterogeneity were analysed by meta-regression analysis and subgroup analysis. All statistical analyses and mapping were performed by RevMan 5.3 and Stata 12.0. Results A total of 41 studies from 14 articles, including 557 preeclampsia patients and 842 controls, were included in our meta-analysis. All studies collected blood before onset. NcRNAs in blood performed relatively well in predicting preeclampsia. The combined sensitivity was 0.71, the specificity was 0.84, and the area under the SROC curve (AUC) was 0.86. Peripheral blood mononuclear cell (PBMC) samples showed the best diagnostic accuracy. The combined AUC was 0.93. Combined detection was better than single detection, and miRNA was better than circRNA. The heterogeneity of the study was determined by sample size, lncRNA characteristics, lncRNA source and race. Conclusion Circulating ncRNAs can be valuable biomarkers used as candidates for noninvasive early predictive biomarkers of preeclampsia and have great clinical application prospects. The clinical value of ncRNAs needs to be tested by further multicentre, comprehensive and prospective studies, and the test criteria should be established.

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Trophoblast microRNAs, pre-eclampsia and intrauterine growth restriction

SPATARO¹,

PASQUINI²,

LUCERI³

2024

Minerva Obstet Gynecol

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419 Role of second-trimester plasma microRNA-210 levels in prediction of preeclampsia: prospective cohort study

Cited by 3 publications

References 0 publications

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: A diagnostic meta-analysis

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: A diagnostic meta-analysis

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis

Trophoblast microRNAs, pre-eclampsia and intrauterine growth restriction

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