42  W femtosecond Yb:Lu_2O_3 regenerative amplifier

Caracciolo, E.; Pirzio, Federico; Kemnitzer, M.; Gorjan, Martin; Guandalini, A.; Kienle, Florian; Agnesi, Antonio; Au, J. Aus der

doi:10.1364/ol.41.003395

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…The industrial femtosecond laser used in our study is commercially available with pulse repetition rates of typically 1 MHz [ 47 ]. Assuming a number of 10 transferred cells per pulse and given that the positioning system is fast enough, a cell transfer rate of a few 10 7 cells per second seems feasible in the future.…”

Section: Discussionmentioning

confidence: 99%

Sacrificial-layer free transfer of mammalian cells using near infrared femtosecond laser pulses

et al. 2018

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Laser-induced cell transfer has been developed in recent years for the flexible and gentle printing of cells. Because of the high transfer rates and the superior cell survival rates, this technique has great potential for tissue engineering applications. However, the fact that material from an inorganic sacrificial layer, which is required for laser energy absorption, is usually transferred to the printed target structure, constitutes a major drawback of laser based cell printing. Therefore alternative approaches using deep UV laser sources and protein based acceptor films for energy absorption, have been introduced. Nevertheless, deep UV radiation can introduce DNA double strand breaks, thereby imposing the risk of carcinogenesis. Here we present a method for the laser-induced transfer of hydrogels and mammalian cells, which neither requires any sacrificial material for energy absorption, nor the use of UV lasers. Instead, we focus a near infrared femtosecond (fs) laser pulse (λ = 1030 nm, 450 fs) directly underneath a thin cell layer, suspended on top of a hydrogel reservoir, to induce a rapidly expanding cavitation bubble in the gel, which generates a jet of material, transferring cells and hydrogel from the gel/cell reservoir to an acceptor stage. By controlling laser pulse energy, well-defined cell-laden droplets can be transferred with high spatial resolution. The transferred human (SCP1) and murine (B16F1) cells show high survival rates, and good cell viability. Time laps microscopy reveals unaffected cell behavior including normal cell proliferation.

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Section: Discussionmentioning

confidence: 99%

Sacrificial-layer free transfer of mammalian cells using near infrared femtosecond laser pulses

et al. 2018

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“…In the other side, the compactness, robustness and cost of the laser system have to be considered when promoting the application of the laser in real scenarios. Compared with scienti c-grade ultrafast (femtosecond) lasers, the industrial-grade lasers delivering picosecond or sub-picosecond pulses, based on the solid-state 51 or inno-slab 52 techniques, could have higher average output powers, more compact con gurations and most-importantly lower costs, all of which would largely bene t the development and popularization of this table-top, wavelength-tunable ultrafast laser technique.…”

Section: Discussionmentioning

confidence: 99%

High-flux, ultraviolet-to-visible-tunable, ultrafast light source based on gas-filled capillary fibre system

Huang,

Liu,

Pan

et al. 2024

Preprint

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Ultrafast light sources with broadband wavelength tunability, as useful tools for studying ultrafast phenomena and light-matter interactions, have attracted extensive interests in recent several decades. High-performance ultrafast pulse generation with simultaneously high pulse repetition rate, high photon flux, and broad wavelength-tuning range covering deep ultraviolet to visible has, however, proven difficult to realize. Here, we demonstrate that through cascading two nonlinear pulse compression stages (one is based on a multi-pass-cell cavity and the other based on a 1-m length of hollow capillary fibre), high-repetition-rate pulses from an industrial-grade high-power picosecond laser can be efficiently compressed to ~15 fs durations, giving rise to an ultrahigh compression ratio of ~74. The generated few-cycle optical pulses, exhibiting excellent beam quality and stability, were used in our set-up to drive the high-efficiency dispersive-wave-emission process in another 1-m length of gas-filled capillary fibre, delivering few-cycle short-wavelength pulses with μJ-level pulse energy, 25 kHz/100 kHz pulse repetition rate, >1016 phs/s photon flux and continuous wavelength-tuning ability from 200 nm to 700 nm. The table-top ultrafast laser system, featuring broad wavelength coverage, may have many potential applications in advanced spectroscopy and ultrafast-optics experiments.

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“…Another approach to implementation of RA systems is based on bulk regenerative amplifiers. The highest output power reported so far for bulk RAs is 42 W at 500 kHz pulse repetition frequency obtained in RA based on the active medium with high thermooptical properties -Yb:Lu 2 O 3 [7]. Relatively long amplified pulses of about 780 fs pulse duration obtained due to narrow gain bandwidth of Yb:Lu 2 O 3 .…”

Section: Introductionmentioning

confidence: 93%

Yb:CALYO-based femtosecond chirped pulse regenerative amplifier for temporally resolved pump-probe spectroscopy

Руденков

Kisel

Yasukevich

et al. 2018

Prib. metody izmer.

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Diode-pumped femtosecond chirped pulse regenerative amplifiers based on Yb3+-materials are of practical importance for wide range of scientific, industrial and biomedical applications. The aim of this work was to study the amplification of broadband chirped femtosecond pulses in regenerative amplifier based on Yb3+:CaYAlO4crystal.Such systems use femtosecond mode-locked lasers as seed pulse sources and amplify nJ-seed pulses to sub-mJ energy range. Most chirped pulse regenerative amplifier systems described in the literature use seed lasers with typical pulse spectral width at the level of 10–15 nm full width at half maximum (FWHM) that limit the seed pulse duration of about 90 fs and amplified pulse duration at the level of 200 fs due to strong influence of gain narrowing effect on the amplified pulse parameters. Yb3+-doped crystals with wide and smooth gain bandwidth as an active medium of chirped femtosecond pulse regenerative amplification systems allow to reduce negative contribution of gain narrowing effect and lead to shortening of amplified pulses. In this research we study the chirped pulse regenerative amplification of broad-band femtosecond pulses (60 nm spectral width FWHM) in the Yb3+:CaYAlO -based chirped pulse regenerative amplifier. Substantial reduction of the amplified pulse duration down to 120 fs (19.4 nm spectral width FWHM) with average power of 3 W at 200 kHz pulse repetition frequency was demonstrated without any gain narrowing compensation technique.The results of experimental investigation of broad-band seeded Yb3+:CaYAlO -based chirped pulse regenerative amplifier are reported for the first time to our knowledge. 120 fs-pulses (19.4 nm FWHM) with average output power of 3 W were demonstrated without any gain narrowing compensation technique. Despite the significant reduction of amplified pulse duration the task of improvement group velocity dispersion balance (including high orders of group velocity dispersion) remains relevant.

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42 W femtosecond Yb:Lu_2O_3 regenerative amplifier

Cited by 7 publications

References 17 publications

Sacrificial-layer free transfer of mammalian cells using near infrared femtosecond laser pulses

Sacrificial-layer free transfer of mammalian cells using near infrared femtosecond laser pulses

High-flux, ultraviolet-to-visible-tunable, ultrafast light source based on gas-filled capillary fibre system

Yb:CALYO-based femtosecond chirped pulse regenerative amplifier for temporally resolved pump-probe spectroscopy

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