420 The effects of bathing, showering and petrolatum on skin barrier function

Bolton, Emily; Ferguson, Adam; Simpson, Brenda; Al-Naqeeb, Jinan; Simpson, Eric L.

doi:10.1016/j.jid.2017.02.439

Cited by 5 publications

(10 citation statements)

References 0 publications

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“…45 A Tewameter TM300 was used to measure TEWL on the ventral surface of both forearms. 45 Results mirrored the study by Bolton et al (2017), with the bathed forearm showing significantly higher TEWL values compared with the showered arm. 45 Fei et al 46 measured TEWL values on both volar forearms.…”

Section: Skincare and Skin Interventionssupporting

confidence: 54%

“…TEWL values were measured for 45 min following the treatment. 44 Results showed that subjects who received a bath compared with a shower had higher TEWL values. 44 Similar results…”

Section: Skincare and Skin Interventionsmentioning

confidence: 95%

“…44 Results showed that subjects who received a bath compared with a shower had higher TEWL values. 44 Similar results…”

Section: Skincare and Skin Interventionsmentioning

confidence: 95%

“…Bolton et al 44 recruited 15 subjects who were given a controlled bath or shower. TEWL values were measured for 45 min following the treatment.…”

Section: Skincare and Skin Interventionsmentioning

confidence: 99%

“…This is likely due to such high variation due to factors such as anatomical location. Akdeniz et al (2018) conducted a 45 study meta-analysis that examined regional variation in TEWL in healthy adult skin, and found averages as low as 2.3 g m −2 h −1 in breast skin and as high as 44.0 g m −2 h −1 in the axilla. 5 I 2 values, a statistical indication of heterogeneity ranging from 0% to 100%, showed values as high as 99.7% in locations such as the mid volar forearm.…”

mentioning

confidence: 99%

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“Normal” TEWL‐how can it be defined? A systematic review

Green

Feschuk

Kashetsky

et al. 2022

Experimental Dermatology

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An optimal amount of water, especially in the stratum corneum, is essential for maintaining normal functioning, healthy skin. 1 Therefore, the amount of water from the skin is carefully regulated, in part through trans-epidermal water loss. 1 Trans-epidermal water loss (TEWL) is an objective measurement of the amount of water passively evaporating from a designated area of stratum corneum in a fixed amount of time due to the water vapour pressure gradient on either side of the skin. It has historically been used as a measure of barrier water function and skin integrity in healthy individuals. 2 Advantages of using a non-invasive marker of skin integrity such as TEWL include a lack of skin barrier destruction, and the potential for early detection of subclinical effects. 3 Elevated TEWL values may reflect barrier dysfunction in diseases such as atopic dermatitis and psoriasis. 4,5 Oppositely, decreased TEWL values reflect an intact or recovered dermal barrier. 5 Thus, TEWL values are typically measured for in vitro permeation testing (IVPT) to reflect a healthy skin sample, and regulatory agencies such as the Food and Drug Administration (FDA) and European Group for Efficacy

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Section: Skincare and Skin Interventionssupporting

confidence: 54%

“…TEWL values were measured for 45 min following the treatment. 44 Results showed that subjects who received a bath compared with a shower had higher TEWL values. 44 Similar results…”

Section: Skincare and Skin Interventionsmentioning

confidence: 95%

“…44 Results showed that subjects who received a bath compared with a shower had higher TEWL values. 44 Similar results…”

Section: Skincare and Skin Interventionsmentioning

confidence: 95%

“…Bolton et al 44 recruited 15 subjects who were given a controlled bath or shower. TEWL values were measured for 45 min following the treatment.…”

Section: Skincare and Skin Interventionsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

“Normal” TEWL‐how can it be defined? A systematic review

Green

Feschuk

Kashetsky

et al. 2022

Experimental Dermatology

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Nurture, not nature: Impaired skin barrier in infants born to Rural Households

Brandwein¹,

Gamrasni²,

Landau³

et al. 2022

Pediatric Allergy Immunology

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To the Editor,The recently introduced epithelial barrier hypothesis posits that the totality of environmental exposures, or the exposome, is responsible for the growing prevalence of an extensive list of disorders, including atopic conditions. 1 Environmental insults damage the epithelial barriers, including that of the skin, thereby setting off a cascade of detrimental events. The theory, coupled with the known genetic underpinnings of atopic dermatitis, asthma, food allergies, and other conditions, provides for a comprehensive picture of geneenvironment interactions that result in disease.The integrity of the skin barrier is important for maintaining health, and its impairment has been associated with a number of medical conditions. Early-life impairment of the skin barrier, as measured by transepidermal water loss (TEWL), has been associated with atopic dermatitis, 2 aeroallergen sensitization, 3 and food allergen sensitization. 4 Intriguingly, these associations are often independent of loss-of-function filaggrin mutations. Filaggrin plays an important role in epidermal integrity, and loss-of-function filaggrin mutations are a risk factor for the development of atopic dermatitis, food allergies, allergic rhinitis, and asthma. 5 However, the lack of overlap between infant TEWL values and subsequent atopic conditions compared with filaggrin mutations and atopic conditions is perplexing. We hypothesized that TEWL values in infancy may reflect environmental exposures and not genetic predisposition. This report explores the hypothesis using data from the Comprehending Atopic Risk Elements (CARE) cohort, an observational prospective birth cohort whose study design has been previously described.The CARE study is a multicenter, prospective observational longitudinal study, and the CARE birth cohort was recruited between June 2020 and April 2022 from a representative sample of births in the Israeli Health Services,

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