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Morimoto, Kazuhiro; Nagayasu, Atsushi; Fukanoki, Shinichi; Morisaka, Katsuaki; Hyon, Suong‐Hyu; Ikada, Yoshito

doi:10.1023/a:1015958710435

Cited by 43 publications

(15 citation statements)

References 3 publications

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“…5-10 PVA has been known as excellent mechanical strength, good film forming, and long-term temperature and pH stability. 11,12 Furthermore, PVA is bio-compatible and nontoxic, and exhibits minimal cell adhesion and protein absorption, as desired in biomedical applications requiring contact with bodily fluid.…”

Section: Introductionmentioning

confidence: 99%

Swelling behavior and drug release of poly(vinyl alcohol) hydrogel cross-linked with poly(acrylic acid)

et al. 2008

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Thermal cross-linking method of poly(vinyl alcohol) (PVA) using poly(acrylic acid) (PAA) was carried out on PVA/PAA hydrogels. The level of gelation was measured in the PVA/ PAA hydrogels with various PAA contents. The swelling behavior at various pHs showed that the swelling kinetics and water contents of the PVA/ PAA hydrogels reached equilibrium after 30 h, and the time to reach the equilibrium state decreased with increasing PAA content in the hydrogel. The water content increased with increasing pH of the buffer solution. The permeation and release of the drug were tested using indomethacin as a model drug. The permeated and released amounts of the drug increased with decreasing the PAA content because of the low free volume in the hydrogel due to the higher cross-linking density. The kinetic profile of drug release at various pHs showed that all samples reached the equilibrium state within the 5 h.

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Section: Introductionmentioning

confidence: 99%

Swelling behavior and drug release of poly(vinyl alcohol) hydrogel cross-linked with poly(acrylic acid)

et al. 2008

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“…21) However, the only inactive pharmaceutical ingredient in the five products (Table 1; SUP-A, SUP-B, SUP-C, SUP-D andSUP-E)ishardfat.InSUP-FandSUP-G,whichhavelow dissolution profiles, SiO 2 and MCT were added in addition to the hard fat, but only the number of carbon atoms in the fatty acid was less (Table 1). So it is unlikely that the additives described above were used in these products.…”

Section: Discussionmentioning

confidence: 99%

Studies on Uniformity of the Active Ingredients in Acetaminophen Suppositories Re-solidified after Melting under High Temperature Conditions

Yamamoto

Fukami

Koide³

et al. 2015

Chem. Pharm. Bull.

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The target of the present pharmaceutical study was the antipyretic analgesic, acetaminophen; its suppository form is usually split when used in pediatric patients. We focused on the active ingredient uniformity in these products, which were re-solidified after melting under high temperature condition. When sections of the cut surfaces of the seven acetaminophen suppository products (SUP-A-G) commercially available in Japan were visualized by polarized microscopy, acetaminophen crystals that were dispersed in the base were identified. The results of the quantitative determination of agent concentration for each cut portion (mg/g) suggested uniform dispersion of these crystals in the base of each product. The agent concentration in each portion of the suppositories that was re-solidified after melting at high temperatures was measured. Segregation of the active ingredient was observed in four products at a temperature of 40°C for 1 h, while active ingredient uniformity was maintained in the other three products (SUP-C, SUP-F and SUP-G). The latter three products also showed high viscosity at 40°C. At 50°C for 4 h, only the uniformity of the active ingredient in SUP-C was maintained. These results suggest that the uniformity of the active ingredient is lost in some acetaminophen suppositories that were re-solidified after melting under high temperature conditions. The degree of loss varies depending on the product.

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“…Poly(vinyl alcohol) (PVA) hydrogels are extensively studied for controlled drug release for various drugs [15–19]. PVA hydrogels must be crosslinked to impart the controlled and sustained release of drugs [20].…”

Section: Introductionmentioning

confidence: 99%

Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

Gajra

Pandya

Singh

et al. 2014

Journal of Drug Delivery

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The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 32 full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and “k” of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol) and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol) and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours.

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Untitled

Cited by 43 publications

References 3 publications

Swelling behavior and drug release of poly(vinyl alcohol) hydrogel cross-linked with poly(acrylic acid)

Swelling behavior and drug release of poly(vinyl alcohol) hydrogel cross-linked with poly(acrylic acid)

Studies on Uniformity of the Active Ingredients in Acetaminophen Suppositories Re-solidified after Melting under High Temperature Conditions

Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

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