Untitled

Zeng, Xianhui; Hirata, Koichi; Tanaka, Hideaki; Hozumi, Akinori; Yamazaki, Kaoru

doi:10.1023/a:1015704827984

Cited by 17 publications

(4 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surprisingly, the P3a component trended towards being larger in the PD group than the CTL group at the FCz electrode (ON vs. CTL: t(48)=1.90, p=.06; OFF vs. CTL: t(48)=1.56, p=.13), in contrast to some previous findings of a diminished P3a (Polich, 2007; Solís-Vivanco et al, 2015; Tsuchiya et al, 2000; Zeng et al, 2002). However, this small component is riding on top of a larger underlying trend; high-pass filtering the data at 1 Hz (as in Solís-Vivanco et al, 2015) removes this shift and reverses these trends (ON vs. CTL: t(48)=−.25, p=.81, OFF vs. CTL t(48)=−.75, p=.46).…”

Section: Resultscontrasting

confidence: 93%

“…While previous studies have found reduced P3a amplitudes in individuals with Parkinson’s disease (Polich, 2007; Tsuchiya et al, 2000; Zeng et al, 2002), the evidence is somewhat mixed across studies (Seer et al, 2016). We demonstrate here that signal processing choices (e.g.…”

Section: Discussionmentioning

confidence: 88%

“…The P3a occurs to novel stimuli, it has a mid-frontal distribution, and it habituates rapidly (Polich, 2007). Individuals with Parkinson’s disease have a smaller P3a than controls (Polich, 2007; Tsuchiya et al, 2000; Zeng et al, 2002), and this component has been advanced as a candidate biomarker of Parkinson’s disease progression, as it is smaller in more severe patients (Solís-Vivanco et al, 2015). It should be noted that the P3a is a part of a family of evoked brain responses that can be difficult to disentangle; recent findings suggest that a later frontal novelty-specific component may be a better representation of the orienting response (Barry et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diminished EEG habituation to novel events effectively classifies Parkinson’s patients

Cavanagh¹,

Kumar²,

Mueller³

et al. 2018

Clinical Neurophysiology

View full text Add to dashboard Cite

show abstract

Section: Resultscontrasting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diminished EEG habituation to novel events effectively classifies Parkinson’s patients

Cavanagh¹,

Kumar²,

Mueller³

et al. 2018

Clinical Neurophysiology

View full text Add to dashboard Cite

show abstract

“…Indeed, past work has found that N2 and ERN amplitudes are diminished in non-demented PD patients, analogous to this study (Seer et al, 2016; Seer et al, 2017), as are P3a amplitudes (Polich, 2007; Solis-Vivanco et al, 2015; Tsuchiya et al, 2000; Zeng et al, 2002). Taken together, these findings suggest a common deficit in the mid-frontal mechanisms that signal the need for cognitive control.…”

Section: Discussionsupporting

confidence: 86%

Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease

et al. 2018

View full text Add to dashboard Cite

Mid-frontal theta activity underlies cognitive control. These 4-8 Hz rhythms are modulated by cortical dopamine and can be abnormal in patients with Parkinson's disease (PD). Here, we investigated mid-frontal theta deficits in PD patients during a task explicitly involving cognitive control. We collected scalp EEG from high-performing PD patients and demographically matched controls during performance of a modified Simon reaction-time task. This task involves cognitive control to adjudicate response conflict and error-related adjustments. Task performance of PD patients was indistinguishable from controls, but PD patients had less mid-frontal theta modulations around cues and responses. Critically, PD patients had attenuated mid-frontal theta activity specifically associated with response conflict and post-error processing. These signals were unaffected by medication or motor scores. Post-error mid-frontal theta activity was correlated with disease duration. Classification of control vs. PD from these data resulted in a specificity of 69% and a sensitivity of 72%. These findings help define the scope of mid-frontal theta aberrations during cognitive control in PD, and may provide insight into the nature of PD-related cognitive dysfunction.

show abstract

Auditory Dysfunction in Parkinson's Disease

2020

View full text Add to dashboard Cite

A BS TRACT: PD is a progressive and complex neurological disorder with heterogeneous symptomatology. PD is characterized by classical motor features of parkinsonism and nonmotor symptoms and involves extensive regions of the nervous system, various neurotransmitters, and protein aggregates. Extensive evidence supports auditory dysfunction as an additional nonmotor feature of PD. Studies indicate a broad range of auditory impairments in PD, from the peripheral hearing system to the auditory brainstem and cortical areas. For instance, research demonstrates a higher occurrence of hearing loss in early-onset PD and evidence of abnormal auditory evoked potentials, event-related potentials, and habituation to novel stimuli. Electrophysiological data, such as auditory P3a, also is suggested as a sensitive measure of illness duration and severity. Improvement in auditory responses following dopaminergic therapies also indicates the presence of similar neurotransmitters (i.e., glutamate and dopamine) in the auditory system and basal ganglia. Nonetheless, hearing impairments in PD have received little attention in clinical practice so far. This review summarizes evidence of peripheral and central auditory impairments in PD and provides conclusions and directions for future empirical and clinical research.Among neurological disorders, which are the leading cause of disability in the world, Parkinson's disease (PD) shows the highest growth in prevalence, rate of deaths, and disability-adjusted life-years between 1990 and 2015, and it is estimated to double over the next 20 years. 1 The etiology of PD is often unknown and mostly occurs in sporadic form, possibly arising from the association of genetic and environmental risk factors. 2,3 As a progressive disease, PD is characterized by early major death of dopaminergic neurons in the SNpc within the basal ganglia that leads to classical parkinsonian and secondary motor symptoms. 2,4 PD pathology involves extensive regions of the nervous system, various neurotransmitters (e.g., dopaminergic and nondopaminergic neurotransmitters), and protein aggregations other than just Lewy bodies or Lewy neurites (i.e., abnormal aggregation of insoluble α-synuclein protein [SNCA]) 2 that account for a wide range of clinical symptoms and signs observed in PD. 5 Thus, multiple nonmotor symptoms (NMSs) develop throughout the PD progress, some of which precede the motor dysfunction by more than a decade. 2 For instance, fatigue, neuropsychiatric symptoms, autonomic dysfunction, gastrointestinal symptoms, sensory deficits (e.g., visual impairments, 6 olfactory dysfunction, 7 taste disorders, 8 somatosensory abnormalities, 9 and auditory disorders 10,11 ), and sleep problems are within common NMSs in early PD. 2,3 Among sensory dysfunctions as NMSs of PD, somatic sensations, such as pain and paraesthesias, have received ---

show abstract

Untitled

Cited by 17 publications

References 60 publications

Diminished EEG habituation to novel events effectively classifies Parkinson’s patients

Diminished EEG habituation to novel events effectively classifies Parkinson’s patients

Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease

Auditory Dysfunction in Parkinson's Disease

Contact Info

Product

Resources

About