426 Clinical improvement in atopic dermatitis following autologous application of microbiome therapy targeting Staphylococcus aureus

Nakatsuji, Teruaki; Yun, Tery; Butcher, A.; Hayashi, Ai; Chun, Kimberly; Shafiq, Faiza; Kim, J.; Zengler, Karsten; Hata, Tissa; Gallo, Richard L.

doi:10.1016/j.jid.2018.03.433

Cited by 13 publications

(9 citation statements)

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“…Furthermore, recent results from a similar 1-week trial have shown that this intervention can significantly improve local Eczema Area and Severity Index scores. 90 Another recent open-label trial that evaluated Roseomonas mucosa found that topical application of this gram-negative organism decreased AD severity, pruritus, and the use of topical corticosteroids. 91 This observation mirrors other reports of anti-inflammatory effects from environmental bacteria 92 but lacks a known mechanism of action.…”

Section: Can Commensal Organisms Be Used As Therapy For Ad?mentioning

confidence: 99%

The microbiome in patients with atopic dermatitis

Paller

Kong

Seed

et al. 2019

Journal of Allergy and Clinical Immunology

373

300

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As an interface with the environment, the skin is a complex ecosystem colonized by many microorganisms that coexist in an established balance. The cutaneous microbiome inhibits colonization with pathogens, such as Staphylococcus aureus, and is a crucial component for function of the epidermal barrier. Moreover, crosstalk between commensals and the immune system is now recognized because microorganisms can modulate both innate and adaptive immune responses. Host-commensal interactions also have an effect on the developing immune system in infants and, subsequently, the occurrence of diseases, such as asthma and atopic dermatitis (AD). Later in life, the cutaneous microbiome contributes to the development and course of skin disease. Accordingly, in patients with AD, a decrease in microbiome diversity correlates with disease severity and increased colonization with pathogenic bacteria, such as S aureus. Early clinical studies suggest that topical application of commensal organisms (eg, Staphylococcus hominis or Roseomonas mucosa) reduces AD severity, which supports an important role for commensals in decreasing S aureus colonization in patients with AD. Advancing knowledge of the cutaneous microbiome and its function in modulating the course of skin disorders, such as AD, might result in novel therapeutic strategies.

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Section: Can Commensal Organisms Be Used As Therapy For Ad?mentioning

confidence: 99%

The microbiome in patients with atopic dermatitis

Paller

Kong

Seed

et al. 2019

Journal of Allergy and Clinical Immunology

373

300

View full text Add to dashboard Cite

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“…There can be two routes to restore the diversity of microbiome on the AD skin: (i) reintroducing natural microbial flora on the skin and/or (ii) decreasing the load of S. aureus . The examples of the first approach have already been proposed ( Nakatsuji et al, 2017 ) and verified in some preliminary human trials based on the application of some representatives of coagulase-negative staphylococci ( Nakatsuji et al, 2018 ) or yet another species, namely Roseomonas mucosa ( Myles et al, 2018 ). The mechanism behind transplanting beneficial microorganisms directly onto the skin might be based on the production of antistaphylococcal compounds by commensal microorganisms or induction of tolerance to a pathogen.…”

Section: Future Perspectives For the Antistaphylococcal Treatmentmentioning

confidence: 99%

Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

et al. 2021

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Atopic dermatitis (AD) patients are massively colonized with Staphylococcus aureus (S. aureus) in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant S. aureus (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of S. aureus accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of S. aureus in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived S. aureus. Also, we summarize the present and potentially useful future anti-staphylococcal treatment.

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“…Another biotech company proposes micro‐encapsulated freeze‐dried Lactobacilli in an oil‐in‐water cream . Last but not least another approach, inspired by the success of faecal microbiota transplantation for the treatment of Clostridium difficile infection , suggests the transplantation of bacterial communities from one individual to another as well as the topical application of selected beneficial bacterial strains to modulate and rebalance the microbiota composition when pathological dysbiosis occurs, for example for the treatment of acne vulgaris or atopic dermatitis . Given the promising results, it is reasonable to assume that, in the near future, we will see more and more cosmetic products embracing the new philosophy of taking care (protect or balance) of the skin microbiota.…”

Section: Present and Future Perspectives In The Skincare Industrymentioning

confidence: 99%

Revealing the secret life of skin ‐ with the microbiome you never walk alone

Sfriso

Egert

Gempeler

et al. 2019

Intern J of Cosmetic Sci

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The human skin microbiome has recently become a focus for both the dermatological and cosmetic fields. Understanding the skin microbiota, that is the collection of vital microorganisms living on our skin, and how to maintain its delicate balance is an essential step to gain insight into the mechanisms responsible for healthy skin and its appearance. Imbalances in the skin microbiota composition (dysbiosis) are associated with several skin conditions, either pathological such as eczema, acne, allergies or dandruff or non‐pathological such as sensitive skin, irritated skin or dry skin. Therefore, the development of approaches which preserve or restore the natural, individual balance of the microbiota represents a novel target not only for dermatologists but also for skincare applications. This review gives an overview on the current knowledge on the skin microbiome, the currently available sampling and analysis techniques as well as a description of current approaches undertaken in the skincare segment to help restoring and balancing the structure and functionality of the skin microbiota.

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426 Clinical improvement in atopic dermatitis following autologous application of microbiome therapy targeting Staphylococcus aureus

Cited by 13 publications

References 0 publications

The microbiome in patients with atopic dermatitis

The microbiome in patients with atopic dermatitis

Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

Revealing the secret life of skin ‐ with the microbiome you never walk alone

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