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Corrêa, Humberto; Marco, Luiz; Viana, Marcelo Machado; Lima, V. F. S.; Campi-Azevedo, Ana Carolina; Noronha, Júlio Carlos; Guatimosim, C.; Romano-Silva, Marco Aurélio

doi:10.1023/a:1021873411611

Cited by 17 publications

(4 citation statements)

References 13 publications

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“…These results reported here in a Chinese population were not in agreement with those reported by Dawei Li, who found no association of the T102C polymorphism with either schizophrenia or suicidal behavior, evidence of significant association was only detected between the A-1438G polymorphism and suicidal behavior [30]. Our results failed to confirm previous reports that genotype frequencies of 102 T/C 5-HT 2A receptor gene polymorphism in mood disorders do not differ from healthy volunteers [31-33]. Moreover, Ho-kyoung Yoon concluded that the 5-HT 2A T102C polymorphism may not be associated with susceptibility to suicidal behavior in Korean population [34].…”

Section: Discussioncontrasting

confidence: 99%

Association study of gene polymorphisms and depression with abnormal humor in traditional Uighur medicine

Yusup

Upur

Abla

et al. 2013

BMC Complement Altern Med

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BackgroundAccording to the humor theory of Traditional Uighur Medicine (TUM), a same disease is classified into different abnormal humor types and corresponding methods are applied to treat the diseases according to the type of abnormal humor characteristics. To date the biological foundation of classification of diseases by humor theory has been little studied and the mechanism of action is still unclear. In the present study, we aimed to investigate the association between some related gene polymorphisms and depression with abnormal humor in TUM.Methods201 cases of depression patients in a Uighur population were divided into two groups as: 107 cases of depression patients with abnormal black bile (ABB), 94 cases of depression patients with none abnormal black bile (nABB), and 50 healthy people were served as control group. Venous blood was used to isolate DNA samples, and the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used for genotyping of single nucleotide polymorphisms (SNPs). Polymorphisms in the serotonin 2A (5-HT2A) receptor gene, brain derived neurotrophic factor (BDNF), serotonin 1A (5-HT1A) receptor gene were investigated in each groups, respectively.ResultsThe 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms showed significant association with ABB. However, no difference between nABB and controls was found for those genotype distribution and allele frequency. Moreover, the T102C and A1438G SNPs in the 5-HT2A receptor gene polymorphisms were in linkage disequilibrium. In addition, the OR associated with the combination of Val66Met-Val/Val genotype plus the presence of -1019C allele was 8.393 for ABB compared with controls (OR 8.393; 95% CI 1.807 ~ 38.991; P= 0.003). Moreover, the OR associated with the presence of -Met plus -1019C alleles was 12.194 for ABB compared with controls (OR 12.194; 95% CI 1.433 ~ 103.776; P= 0.005). The OR associated with the presence of -1438C/C plus Val/Val genotypes was 7.738 for ABB compared with controls (OR 7.738; 95% CI 1.566 ~ 38.241; P= 0.005).ConclusionIt was concluded that there were significant relationship between the gene polymorphisms and classification of depression with abnormal humor in TUM. The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB.

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Section: Discussioncontrasting

confidence: 99%

Association study of gene polymorphisms and depression with abnormal humor in traditional Uighur medicine

Yusup

Upur

Abla

et al. 2013

BMC Complement Altern Med

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“…One of the most remarkable single nucleotide polymorphisms of the 5HTR2A gene is T102C (rs6313). Several genetic studies have shown an association between 5HTR2A and suicidal behavior [17,18]. Similarly, this common variant has been studied not only in relation to suicidal behavior, but also in association with other diseases such as schizophrenia [19-21], alcoholism [22], and depression [23].…”

Section: Introductionmentioning

confidence: 99%

Association of the 5HTR2A gene with suicidal behavior: CASE-control study and updated meta-analysis

et al. 2013

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BackgroundThe polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to examine the association between T102C with suicidal behavior in a case–control study and, to assess the combined evidence – this case–control study and available data from other related studies – we carried out a meta-analysis.MethodsWe conducted a case–control study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia.ResultsWe found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09).ConclusionOur results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.

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“…Таким образом, в соответствии с полученными результатами полиморфизм T102C гена 5-HTR2A связан с суицидальным поведением. Несколько других исследований также показали связь между геном 5-HTR2A и суицидальным поведением [6,9], указав на заметное увеличение риска суицидального поведения у носителей аллеля С для полиморфизма T102C гена 5-HTR2A. Тем не менее авторы проведенного в 2013 г. мета-анализа опровергают наличие какой-либо связи гена рецептора серотонина типа 2А с суицидальностью [5].…”

Section: таблицаunclassified

Influence of T102c Polymorphism of the 5-Htr2a Gene on Clinical Characteristics of Paranoid Schizophrenia

Kolesnichenko¹

2015

СПНО (MPSE)

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Цель исследования -оценить влияние T102C полиморфизма гена 5-HTR2A (rs6313) на формирование клинической картины параноидной шизофрении у русских на примере популяции Саратовской области. В исследовании принимали участие больные параноидной шизофренией (n=206) и группа здоровых испытуемых (n=96). Для оценки психопатологического состояния и отдельных психопатологических симптомов использовали «Оценочный перечень симптомов и глоссарий для психических расстройств. МКБ-10» и шкалу SADS-L «Schizophrenia and Affective Disorders Scale». Мы обнаружили, что полиморфизм T102C гена 5-HTR2A в гомозиготном варианте (TT или СС) ассоциирован с повышенным риском развития параноидной шизофрении (HWE p<0,05). Не было обнаружено ассоциации генотипа гена 5-HTR2A c возрастом начала, типом течения шизофренического процесса и отдельными клиническими симптомами шизофрении (р>0,05). Обнаружена ассоциация генотипа СС для полиморфизма T102C гена 5-HTR2A с суицидальным поведением у больных параноидной шизофренией.

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Cited by 17 publications

References 13 publications

Association study of gene polymorphisms and depression with abnormal humor in traditional Uighur medicine

Association study of gene polymorphisms and depression with abnormal humor in traditional Uighur medicine

Association of the 5HTR2A gene with suicidal behavior: CASE-control study and updated meta-analysis

Influence of T102c Polymorphism of the 5-Htr2a Gene on Clinical Characteristics of Paranoid Schizophrenia

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