438: Disruption of maternal tolerance during pregnancy leads to treg repopulation of the antigenic UPI

Collier, Ai‐ris Y.; Cook, H. Terence; Loewendorf, Andrea; Yesayan, Maria; Kahn, Daniel

doi:10.1016/j.ajog.2014.10.484

Cited by 1 publication

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“…Tolerance is a specific immunological term that refers to “the active state of antigen‐specific non‐responsiveness” leading to diminished reactivity to paternal antigens expressed by the placenta and/or fetus; it is considered key for successful pregnancy . The mechanisms responsible for tolerance in pregnancy include the following: (i) T‐cell chemokine gene silencing in the decidual cells; (ii) a suppressive role of regulatory T cells; (iii) expression of non‐classical major histocompatibility complex molecules on trophoblast cells that do not elicit a maternal immune response; (iv) changes in tryptophan catabolisms; (v) T‐cell apoptosis; (vi) complement; and (vii) costimulatory molecules such as the programmed death ligand . Other mechanisms for tolerance are not currently understood.…”

Section: Introductionmentioning

confidence: 99%

CXCL10 and IL‐6: Markers of two different forms of intra‐amniotic inflammation in preterm labor

Romero

Chaemsaithong

Chaiyasit

et al. 2017

American J Rep Immunol

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ProblemTo determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM).Method of StudyThis study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)‐6 and CXCL10 concentrations were determined by immunoassay.Results(i) Increased AF CXCL10 concentration was associated with chronic (OR: 4.8; 95% CI: 1.7‐14), but not acute chorioamnionitis; (ii) increased AF IL‐6 concentration was associated with acute (OR: 4.2; 95% CI: 1.3‐13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL10 concentration was associated with placental lesions consistent with maternal anti‐fetal rejection (OR: 3.7; 95% CI: 1.3‐10.4). (iv) All patients with elevated AF CXCL10 and IL‐6 delivered preterm.ConclusionIncreased AF CXCL10 concentration is associated with chronic chorioamnionitis or maternal anti‐fetal rejection, whereas increased AF IL‐6 concentration is associated with acute histologic chorioamnionitis.

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