[44] Actions of flavonoids and coumarins on lipoxygenase and cyclooxygenase

Hoult, J.R.S.; Moroney, Michele A.; Payá, Miguel

doi:10.1016/0076-6879(94)34115-x

Cited by 142 publications

(74 citation statements)

References 16 publications

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“…The nitrite concentration in culture supernatants, as a reflection of NO release, was determined fluorometrically (Misko et al, 1993). PGE 2 levels were determined by radioimmunoassay (Hoult et al, 1994).…”

Section: Methodsmentioning

confidence: 99%

“…A suspension of human neutrophils (5 ϫ 10 6 cells/ml) was preincubated with test compound or vehicle and then stimulated with the calcium ionophore A23187 (1 M) for 10 min at 37°C. LTB 4 levels in supernatants were measured by radioimmunoassay (Hoult et al, 1994). High speed (100,000g) supernatants from sonicated human neutrophils were obtained and incubated in appropriate conditions with 10 M arachidonic acid to assess 5-lipoxygenase activity (Tateson et al, 1988).…”

Section: Methodsmentioning

confidence: 99%

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Modulatory Effect of Bolinaquinone, a Marine Sesquiterpenoid, on Acute and Chronic Inflammatory Processes

Lucas¹,

Giannini²,

D’Auria³

et al. 2002

J Pharmacol Exp Ther

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The marine metabolite bolinaquinone is a novel inhibitor of secretory phospholipase A 2 (sPLA 2 ), with a potency on the human synovial enzyme (group II) higher than that of manoalide. This activity on the sPLA 2 was confirmed in vivo in the 8-h zymosan rat air pouch on the secretory enzyme accumulation in the pouch exudate. Additionally, bolinaquinone decreased potently the synthesis and release of leukotriene B 4 (LTB 4 ) in calcimycin (A23187)-stimulated human neutrophils as a consequence of the inhibition of 5-lipoxygenase activity, as well as PGE 2 and NO production on zymosan-stimulated mouse peritoneal macrophages. This compound exerted anti-inflammatory effects by topical and oral routes on the mouse ear edema induced by 12-O-tetradecanoylphorbolacetate, with ID 50 values of 76.7 g/ear and 5.6 mg/kg, respectively, with a significant decrease in PGE 2 , LTB 4 , and tumor necrosis factor-␣ (TNF-␣) levels being more effective than indomethacin. This effect was confirmed in the mouse paw carrageenan edema after oral administration. Moreover, bolinaquinone was able to reduce the inflammatory response of adjuvant arthritis by inhibiting PGE 2 , NO, and TNF-␣ production in paw homogenates without affecting PGE 2 levels in the stomach. Additionally, bolinaquinone inhibited inducible nitric oxide synthase expression and reduced the degree of bone resorption, soft tissue swelling, and osteophyte formation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Modulatory Effect of Bolinaquinone, a Marine Sesquiterpenoid, on Acute and Chronic Inflammatory Processes

Lucas¹,

Giannini²,

D’Auria³

et al. 2002

J Pharmacol Exp Ther

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“…Flavonoids are reported to possess anti-inflammatory, antihepatotoxic, anticancer, antiviral activities, and antibacterial effects (Cook and Samman, 1996;Russo et al, 2002). The main opinion toward the wide biological activities of flavonoids is related to their ability to protect against the damaging effect of free radicals (Hoult et al, 1994;Russo et al, 2002;Cotelle et al, 1996). In another experiment, Lin and his co workers have reported that propolis ethanol extract can significantly prevent the elevations of rat liver microsomal enzymes and lipid peroxidation after chronic alcohol administration.…”

Section: Molecular Docking Studymentioning

confidence: 93%

Bioinformatic Prediction of Interaction between Flavonoids of Propolis of Honey Bee and Envelope Glycoprotein GP120

Gavanji¹,

Larki²,

Mortazaeinezhad³

2014

IJSRES

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Abstract. Acquired immune deficiency syndrome (AIDS) is a kind of disease related to immune system caused by HIV virus. Up to now many medicinal compositions have been using for treatment of this disease both in In vivo and In vitro conditions. Caffeic Acid Phenethyl Ester (CAPE) is one of the most important compositions in honey bee propolis. The composition possesses anti-bacterial, anti-viral, anti-fungal, anti-oxidant, anti-inflammatory and anti-cancer properties. In this study we tried to predict bioinformatic interaction between CAPE and GP120. Molegro virtual docker (MVD) is used. The results obtained from docking showed us that the best pose which is derived from MolDock score for GP120 was -89.9759 with reranking score equal to -61. 1094. Bioinformatic studies show that Caffeic Acid Phenethyl Ester has interaction with Envelope glycoprotein GP120.

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“…NSAID block the synthesis of prostaglandins by inhibiting cyclooxygenase (Cox). Cox and 5-lipoxygenase (5-LO) catalyze peroxidation of arachidonic acid and polyphenols such as coumarins and flavonoids might be expected to interfere with this process [21]. The presence of coumarins, 3…”

Section: Dicussionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Activity of Various Extracts of Clausena Dentata (Willd.) Roem

Kamaraj

Maduram

2018

Asian J Pharm Clin Res

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Objectives: The present study was undertaken to study the analgesic and anti-inflammatory activity of various extracts of Clausena dentata. Clausena (Rutaceae) is a genus of about 23 species of unarmed trees and shrubs. The stem bark of C. dentata is used in veterinary medicine for the treatment of wounds and sprains. Even though C. dentata has a lot of potential medical uses, the study of pharmacological properties is very scarce. Methods:The plant C. dentata was collected in May 1999 from Kadagaman, near Tiruvannamalai, Tamil Nadu, India, and authenticated by Centre for Advanced Study in Botany, University of Madras, Chennai. The dry powder of stem bark was extracted with hexane, chloroform, and methanol. The extracts were subjected to thin-layer chromatography and phytochemical screening. Further, the extracts were tested for analgesic by the tail flick and anti-inflammatory by carrageenan-induced rat paw edema using plethysmometer. Results:Qualitative chemical tests revealed the presence of various phytochemicals such as alkaloids, glycosides, carbohydrate, proteins and amino acids, phytosterols, and volatile oil. The hexane, chloroform, and methanol extracts exhibited significant analgesic activity as compared to control group (Tween 80, 1%). The anti-inflammatory activity of C. dentata extracts revealed that the percent inhibition of carrageenan-induced rat hind paw edema was highly significant as compared to control group after 4 h of injection. Conclusion:The presence of coumarin and alkaloids all the extracts promising properties of analgesic and anti-inflammatory.

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[44] Actions of flavonoids and coumarins on lipoxygenase and cyclooxygenase

Cited by 142 publications

References 16 publications

Modulatory Effect of Bolinaquinone, a Marine Sesquiterpenoid, on Acute and Chronic Inflammatory Processes

Modulatory Effect of Bolinaquinone, a Marine Sesquiterpenoid, on Acute and Chronic Inflammatory Processes

Bioinformatic Prediction of Interaction between Flavonoids of Propolis of Honey Bee and Envelope Glycoprotein GP120

Analgesic and Anti-Inflammatory Activity of Various Extracts of Clausena Dentata (Willd.) Roem

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