45. Amino-oxy-derivatives. Part II. Some derivatives of N-hydroxydiguanide

Mamalis, P.; Green, J.; McHale, D.

doi:10.1039/jr9600000229

Cited by 24 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several older studies have been conducted on the antimicrobial effect of aminooxy compounds, with M. tuberculosis included amongst the organisms tested [35-39]. From these papers, the only compound in common with the present study was carboxymethoxylamine, which was found to have an MIC of 313 μM (present data), 910 μM [35], 170 – 686 μM [36], or 170 μM [37].…”

Section: Discussionmentioning

confidence: 57%

Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis

et al. 2004

View full text Add to dashboard Cite

Background: Tuberculosis remains a major world-wide health threat which demands the discovery and characterisation of new drug targets in order to develop future antimycobacterials. The regeneration of methionine consumed during polyamine biosynthesis is an important pathway present in many microorganisms. The final step of this pathway, the conversion of ketomethiobutyrate to methionine, can be performed by aspartate, tyrosine, or branched-chain amino acid aminotransferases depending on the particular species examined.

show abstract

Section: Discussionmentioning

confidence: 57%

Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The preparation of some compounds of types (1) and (III to VI) as potential antibacterials based on hydroxylamine has been described by McHale, Green, and and by Mamalis, Green, and McHale (1960); the antibacterial properties of these compounds are now described. In order to facilitate comparisons with existing data, some of the alkoxyamines (I) of Fuller and examined: R = hydrogen (hydroxylamine), ethyl, n-propyl, isopropyl, n-butyl, n-pentyl, n-hexyl, heptyl, decyl, dodecyl, and benzyl.…”

Section: Rch(co2h)onhc(:nh)nhc(:nh)nh2 (Vi)mentioning

confidence: 99%

The ANTIMICROBIAL PROPERTIES OF SOME Α‐AMINO‐OXY‐ACIDS, Α‐AMINO‐OXY‐HYDRAZIDES, ALKOXYAMINES, ALKOXYDIGUANIDES AND THEIR DERIVATIVES

Price

Mamalis

McHale

et al. 1960

British Journal of Pharmacology and Chemotherapy

Self Cite

View full text Add to dashboard Cite

A series of compounds containing an amino‐oxy‐group has been examined for antibacterial and antifungal activity. The amino‐oxy‐acids and the alkoxyamines showed little activity, but the hydrazides, notably the amino‐oxydodecyl and the amino‐oxytetradecyl compounds, had appreciable activity against Staphylococcus aureus. The alkoxydiguanides showed considerable bactericidal activity in vitro against Gram‐positive and Gram‐negative organisms and some activity against Mycobacterium tuberculosis. The most active compounds were those with a chain containing 10 to 14 carbon atoms, but the activity was considerably reduced in the presence of serum. They were also active against the few fungi tested. The most active compound, decyloxydiguanide, was moderately toxic when administered intraperitoneally to mice and no therapeutic activity could be demonstrated against an intraperitoneal injection of Streptococcus pyogenes administered 15 min. previously.

show abstract

“…Previously, commercially available hydrazides derived from nicotinic or isonicotinic acids and cyanoguanidine reacted to each other, under reflux for 8 h in an acidic (HCl) ethanol solution (37%) as solvent, furnishing biguanides 2 and 3 in good yields (!80%) [24].…”

Section: Resultsmentioning

confidence: 97%

Convergent procedure for the synthesis of trifluoromethyl-containing N-(pyridinyl-triazolyl)pyrimidin-2-amines

Bonacorso¹,

Bortolotto²,

Navarini³

et al. 2010

Journal of Fluorine Chemistry

View full text Add to dashboard Cite

45. Amino-oxy-derivatives. Part II. Some derivatives of N-hydroxydiguanide

Abstract: The preparation of some amino-oxyalkanes and their corresponding di-A sum-guanides, together with certain arylmethyl analogues, is described. mary of bacteriostatic activities is included.

Cited by 24 publications

References 0 publications

Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis

Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis

The ANTIMICROBIAL PROPERTIES OF SOME Α‐AMINO‐OXY‐ACIDS, Α‐AMINO‐OXY‐HYDRAZIDES, ALKOXYAMINES, ALKOXYDIGUANIDES AND THEIR DERIVATIVES

Convergent procedure for the synthesis of trifluoromethyl-containing N-(pyridinyl-triazolyl)pyrimidin-2-amines

Contact Info

Product

Resources

About