455 Improvement of Serum Testosterone in Diabetic Rats Treated with Metformin and Nigella Sativa

Abstract

AbstractsResults Both cases presented with abdominal pain and hepatomegaly, combined with nausea and dyspeptic complaints. Laboratory investigation revealed marked elevation of serum transaminase levels. Synthetic function of the liver stayed intact. Abdominal ultrasound showed isolated, homogenous hepatomegaly, without other abdominal abnormalities. In one case liver biopsy was performed, showing hepatic glycogenosis. Other causes for hepatomegaly were excluded. With improved diabetic control all complaints improved within three weeks, with normalisation of serum transaminase levels. Review of literature that hepatic glycogenosis, not frequently described, is an important complication of type I diabetes mellitus. Hepatic glycogenosis as result of glycogen storage in hepatocytes, caused by periods of hyperglycaemia and frequent insulin boluses. This process is reversible with improved glycaemic control.

Influence of chrysin on D‐galactose induced‐aging in mice: Up regulation of AMP kinase/liver kinase B1/peroxisome proliferator‐activated receptor‐γ coactivator 1‐α signaling pathway

“…By contrast, we observed that chrysin stimulated mitochondrial autophagy, as it produced an increase in AMPK level and upregulated PGC-1α and LKB1. In addition, PGC-1α is a mitochondrial biogenesis-related gene upregulated by an antioxidant defense system as Nuclear factor-erythroid 2-related factor 2 (Nrf2) that is reduced with age producing brain function decline, which is associated with ROS and mitochondrial dysfunction [60,61]. Nrf2 coordinates detoxification and antioxidant genes as NQO1 and HO-1 expression [62].…”

Chitosan-Stabilized Selenium Nanoparticles and Metformin Synergistically Rescue Testicular Oxidative Damage and Steroidogenesis-Related Genes Dysregulation in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

“…MF showed close synergistic interaction with other drugs, like rapamycin, in the rat model of testicular torsion/detorsion-induced ischemia/reperfusion [ 93 ]. Additionally, MF and the Nigella sativa dietary supplement synergistically improved serum testosterone in diabetic rats [ 94 ].…”