46. Menin Is a Beta-Catenin Associated Agonist of the Wnt Signaling Pathway in Pancreatic Endocrine Cells

Sawicki, Mark; Gao, Chen; Farley, Steve

doi:10.1016/j.jss.2007.12.053

Cited by 2 publications

(1 citation statement)

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“…Menin (MEN I), a transcription factor product of multiple endocrine neoplasia type I, is a tumor suppressor gene [93] that is localized to the nucleus and is also critical mediator of synapse formation between neurons. Moreover, menin has an essential role in Wnt/β-catenin signaling through histone methylation of downstream target gene promoters [94]. The Wnt/β-catenin pathway, a canonical Wnt signaling pathway, has a significant role in neural development, axonal guidance, neuropathic pain remission and neuronal survival [95].…”

Section: New Targets In Neuropathic Pain Treatmentmentioning

confidence: 99%

An integrated review on new targets in the treatment of neuropathic pain

Khangura

Sharma

Bali

et al. 2019

Korean J Physiol Pharmacol

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Neuropathic pain is a complex chronic pain state caused by the dysfunction of somatosensory nervous system, and it affects the millions of people worldwide. At present, there are very few medical treatments available for neuropathic pain management and the intolerable side effects of medications may further worsen the symptoms. Despite the presence of profound knowledge that delineates the pathophysiology and mechanisms leading to neuropathic pain, the unmet clinical needs demand more research in this field that would ultimately assist to ameliorate the pain conditions. Efforts are being made globally to explore and understand the basic molecular mechanisms responsible for somatosensory dysfunction in preclinical pain models. The present review highlights some of the novel molecular targets like D-amino acid oxidase, endoplasmic reticulum stress receptors, sigma receptors, hyperpolarization-activated cyclic nucleotide-gated cation channels, histone deacetylase, Wnt/β-catenin and Wnt/Ryk, ephrins and Eph receptor tyrosine kinase, Cdh-1 and mitochondrial ATPase that are implicated in the induction of neuropathic pain. Studies conducted on the different animal models and observed results have been summarized with an aim to facilitate the efforts made in the drug discovery. The diligent analysis and exploitation of these targets may help in the identification of some promising therapies that can better manage neuropathic pain and improve the health of patients.

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Section: New Targets In Neuropathic Pain Treatmentmentioning

confidence: 99%

An integrated review on new targets in the treatment of neuropathic pain

Khangura

Sharma

Bali

et al. 2019

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

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Early Changes of β-Catenins and Menins in Spinal Cord Dorsal Horn after Peripheral Nerve Injury

et al. 2010

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Injury to the peripheral nervous system can lead to spontaneous pain, hyperalgesia and allodynia. Previous studies have shown sprouting of Abeta-fibres into lamina II of the spinal cord dorsal horn after nerve injury and the formation of new synapses by these sprouts. beta-Catenin and menin as synaptogenic factors are critically involved in synapse formation. However, the roles of beta-catenin and menin in neuropathic pain are still unclear. Using Western blot analysis we investigated the changes of beta-catenin and menin in the spinal dorsal horn after unilateral spared nerve injury (SNI). We demonstrated an increase in both beta-catenin and menin protein levels in the ipsilateral spinal dorsal horn at days 1 and 3 following spared nerve injury (P < 0.05). These increases were associated with changes in paw withdrawal threshold to mechanical stimuli and weight bearing deficit suggestive of pain behavior and spontaneous ongoing pain respectively. However, the injury-associated increases in beta-catenins and menins levels returned to control levels at day 14. In conclusion, these results indicate that peripheral nerve injury induces upregulation of beta-catenins and menins in the dorsal horn of the spinal cord, which may contribute to the development of chronic neuropathic pain. Antagonists of these molecules may serve as new therapeutic agents.

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46. Menin Is a Beta-Catenin Associated Agonist of the Wnt Signaling Pathway in Pancreatic Endocrine Cells

Cited by 2 publications

References 0 publications

An integrated review on new targets in the treatment of neuropathic pain

An integrated review on new targets in the treatment of neuropathic pain

Early Changes of β-Catenins and Menins in Spinal Cord Dorsal Horn after Peripheral Nerve Injury

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