47 Sensitivity and Specificity of Fecal Elastase 1 in Children: Comparison With the Sekretin-Pancreozymin-Test

Henker, J; Soldan, W.; Sprössig, C

doi:10.1097/00005176-199605000-00060

Cited by 3 publications

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“…Our results are in agreement with those of Terbrack et al [12] and of Henker et al [5] who found a sensitivity of 90% and 100%, respectively, and a speci®city of 99% and 96%, respectively, in children with CF. Moreover, they also agree with published studies on adults with chronic pancreatitis [1,4,6,7,10], which have also demonstrated that FE1 has a high sensitivity and speci®city, greater than those of chymotrypsin, in the diagnosis of exocrine pancreatic insuciency.…”

Section: Discussionsupporting

confidence: 94%

Faecal elastase 1 in children with cystic fibrosis

Gullo

Graziano

Babbini

et al. 1997

European Journal of Pediatrics

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Section: Discussionsupporting

confidence: 94%

Faecal elastase 1 in children with cystic fibrosis

Gullo

Graziano

Babbini

et al. 1997

European Journal of Pediatrics

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“…The FchT is altered by exogenous enzymes and is therefore useful to monitor for compliance [55]. The test has a sensitivity ranging from 50% to 80% for advanced EPI [57] but only 50% for mild to moderate EPI [58]. Also, the specificity is lower than the FET [57].…”

Section: Practice Pointsmentioning

confidence: 99%

Pancreatic enzyme replacement therapy in chronic pancreatitis

Sikkens

Cahen

Kuipers

et al. 2010

Best Practice & Research Clinical Gastroenterology

115

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“…The loss of exocrine pancreatic function leads to maldigestion and malabsorption. (33)(34)(35)(36)(37)(38). In a pilot study published by Wallis et al (30) on stool obtained from 30 children with CF (aged 1 day to 16 years), three neonates with CF had serial testing performed during the first 3 weeks of life.…”

Section: Elastase-1 and Cystic Fibrosismentioning

confidence: 99%

Fecal Elastase-1 as a Test for Pancreatic Function: a Review

Dominici¹,

Franzini²

2002

Clinical Chemistry and Laboratory Medicine

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Pancreatic elastase-1 is a specific human protease synthetized by the acinar cells. Immunoreactive elastase-1 cannot be detected in either porcine or bovine pancreatic enzyme preparations. It is very stable and, in contrast to fecal chymotrypsin, elastase is unaffected by exogenous pancreatic enzyme treatment, and correlates well with exocrine pancreatic function tests. The measurement of this proteolytic enzyme in stool by means of an enzyme-linked immunosorbent assay (ELISA) is a sensitive, specific, and relatively inexpensive non-invasive test. It is an accurate function test for patients with chronic pancreatitis confirmed by endoscopic retrograde cholangiopancreatography and computerized axial tomography. It shows higher sensitivity and specificity for exocrine pancreatic insufficiency than fecal chymotrypsin determination and is comparable to oral pancreatic function tests such as the pancreolauryl test.

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47 Sensitivity and Specificity of Fecal Elastase 1 in Children: Comparison With the Sekretin-Pancreozymin-Test

Cited by 3 publications

References 0 publications

Faecal elastase 1 in children with cystic fibrosis

Faecal elastase 1 in children with cystic fibrosis

Pancreatic enzyme replacement therapy in chronic pancreatitis

Fecal Elastase-1 as a Test for Pancreatic Function: a Review

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