473 Autofluorescence Assessment in the Surveillance of Barrett's Oesophagus: A Randomised Trial Comparing Standard 4 Quadrant Biopsy and AF Directed Biopsy

Endoscopic diagnosis and treatment of upper gastrointestinal tumors

“…New methods for targeted biopsy are being sought to replace random biopsy; it is anticipated that targeted biopsy will detect more dysplasia and more advanced dysplasia using fewer tissue samples. Candidate methods include autofluor− escence imaging [1], confocal laser endomicros− copy [2,3], and high−resolution endoscopy with narrow−band imaging (NBI) [4]. Selected studies on this topic are summarized in l " Table 1.…”

Reflux disease and Barrett’s esophagus

“…Over the past several years, various advanced imaging techniques have been devel− oped in order to better detect dysplasia within Barrett's esopha− gus and improve the yield of surveillance biopsies. McCallum and colleagues presented the results of a randomized crossover trial in which upper endoscopies were performed 2 months apart [34]. On one endoscopy (the order being random), random four−quadrant biopsies were performed as per the Seattle proto− col using standard−resolution white−light endoscopy (WLE).…”