47Sc production development by cyclotron irradiation of 48Ca

Misiak, R.; Walczak, Rafał; Wąs, Bogdan; Bartyzel, Mirosław; Mietelski, Jerzy W.; Bilewicz, Aleksander

doi:10.1007/s10967-017-5321-z

Cited by 58 publications

(65 citation statements)

References 24 publications

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“…The production of 47 target [37] high-purity 47 Sc was obtained in low yield which was, however, sufficient for a preclinical study. In the latter case [66], only the (p,2n) reaction cross section was measured.…”

Section: Production Of 47 Scmentioning

confidence: 99%

New developments in the production of theranostic pairs of radionuclides

Qaim

Schölten

Neumaier

2018

J Radioanal Nucl Chem

132

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A brief historical background of the development of the theranostic approach in nuclear medicine is given and seven theranostic pairs of radionuclides, namely 44g Sc/ 47 Sc, 64 Cu/ 67 Cu, 83 Sr/ 90 Sr, 86 Y/ 90 Y, 124 I/ 131 I, 152 Tb/ 161 Tb and 152 Tb/ 149 Tb, are considered. The first six pairs consist of a positron and a β −-emitter whereas the seventh pair consists of a positron and an α-particle emitter. The decay properties of all those radionuclides are briefly mentioned and their production methodologies are discussed. The positron emitters 64 Cu, 86 Y and 124 I are commonly produced in sufficient quantities via the (p,n) reaction on the respective highly enriched target isotope. A clinical scale production of the positron emitter 44g Sc has been achieved via the generator route as well as via the (p,n) reaction, but further development work is necessary. The positron emitters 83 Sr and 152 Tb are under development. Among the therapeutic radionuclides, 89 Sr, 90 Y and 131 I are commercially available and 161 Tb can also be produced in sufficient quantity at a nuclear reactor. Great efforts are presently underway to produce 47 Sc and 67 Cu via neutron, photon and charged particle induced reactions. The radionuclide 149 Tb is unique because it is an α-particle emitter. The present method of production of 152 Tb and 149 Tb involves the use of the spallation process in combination with an on-line mass separator. The role of some emerging irradiation facilities in the production of special radionuclides is discussed.

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Section: Production Of 47 Scmentioning

confidence: 99%

New developments in the production of theranostic pairs of radionuclides

Qaim

Schölten

Neumaier

2018

J Radioanal Nucl Chem

132

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“…The cyclotron production of 47 Sc via the 48 Ca(p,2n) 47 Sc nuclear reaction has been reported, with a proton energy range of 24 → 17 MeV regarded as optimal for this purpose. The radionuclidic purity using this route was determined to be only 85% to 87%, however . Should one utilize enriched 48 Ca as target material, it is envisaged that irradiation with 17.5 to 20 MeV protons will produce GBq activities of 47 Sc, along with 47 Ca (which will decay to 47 Sc) and 48 Sc, but the high cost of enriched 48 Ca has prevented further practical investigation to date .…”

Section: Radiometals For Theranostic Applicationsmentioning

confidence: 99%

“…93 This was compared with its 44 Sc-and 47 Sc-labelled counterparts. 93 The production of 47 Sc can be achieved via various nuclear reactions using a cyclotron, 94 reactor, 95 or electron linear accelerator (eLINAC). [96][97][98][99] The cyclotron production of 47 Sc via the 48 Ca(p,2n) 47 Sc nuclear reaction has been reported, with a proton energy range of 24 → 17 MeV regarded as optimal for this purpose.…”

Section: /44/47 Scmentioning

confidence: 99%

“…94,100 Should one utilize enriched 48 Ca as target material, it is envisaged that irradiation with 17.5 to 20 MeV protons will produce GBq activities of 47 Sc, along with 47 Ca (which will decay to 47 Sc) and 48 Sc, but the high cost of enriched 48 Ca has prevented further practical investigation to date. 94,100 Carzaniga and Braccini 100 reported a cross section of approximately 240 mb at 17.5 MeV for the 48 Ca(p,pn) 47 Ca nuclear reaction, indicating a viability of utilizing a 47 Ca/ 47 Sc generator concept. The concept of using the eLINAC and irradiating 48 Ca via the (γ,n) 47 Ca → 47 Sc was investigated.…”

Section: /44/47 Scmentioning

confidence: 99%

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Radiometals for imaging and theranostics, current production, and future perspectives

Mikołajczak

Meulen

Lapi

2019

Labelled Comp Radiopharmac

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The aim of this review is to make the reader familiar with currently available radiometals, their production modes, capacities, and quality concerns related to their medical use, as well as new emerging radiometals and irradiation technologies from the perspective of their diagnostic and theranostic applications. Production methods of 177Lu serve as an example of various issues related to the production yield, specific activity, radionuclidic and chemical purity, and production economy. Other radiometals that are currently used or explored for potential medical applications, with particular focus on their theranostic value, are discussed. Using radiometals for diagnostic imaging and therapy is on the rise. The high demand for radiometals for medical use prompts investigations towards using alternative irradiation reactions, while using existing nuclear reactors and accelerator facilities. This review discusses these production capacities and what is necessary to cover the growing demand for theranostic nuclides.

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“…However, the same channels are well described in the case of 46 Sc population. Therefore, additional measurements of the former residual nucleus and deuteron energies of 30-40 MeV seems to be of interest as long as Sc isotopes are important for the development of therapeutic radio-pharmaceuticals [81].…”

Section: The (D αXnyp) Reactionsmentioning

confidence: 99%

Consistent account of deuteron-induced reactions on natCr up to 60 MeV

et al. 2018

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sive BU and DR cross sections is still investigated numerically (e.g., [2] and Refs. therein). On the other hand, the sparce deuteron-breakup experimental data systematics [3][4][5][6][7] related to the high complexity of the breakup mechanism has constrained so far a comprehensive analysis of the deuteron interactions within wide ranges of target nuclei and incident energies. Thus, reaction cross sections recommended most recently for high-priority elements are still based on data fit, e.g. by various-order Pade approximations [8], with so low predictive power and apart from nuclear modeling advance.Consequently, complementary measurements and model calculations are necessary in order to meet the demands of several on-going strategic research programmes of international large-scale facilities [9-11] and databases [12]. The present work aims both to enhance the database of deuteron-induced reactions on natural chromium, up to 20 MeV, and continue a series of recent analyzes [13][14][15][16][17][18] looking for the consistent inclusion of the deuteron BU contribution within activation cross-section account. The experimental setup as well the new mea-

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47Sc production development by cyclotron irradiation of 48Ca

Cited by 58 publications

References 24 publications

New developments in the production of theranostic pairs of radionuclides

New developments in the production of theranostic pairs of radionuclides

Radiometals for imaging and theranostics, current production, and future perspectives

Consistent account of deuteron-induced reactions on natCr up to 60 MeV

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