48 Gemcitabine plus carboplatin (GCb) with optional radiotherapy (Rt) for treatment of locally advanced non small cell lung cancer (NSCLC): preliminary results

Gemcitabine and radiation therapy in non-small cell lung cancer: state of the art

“…Full-dose gemcitabine-based combinations have been studied in the induction setting in several trials. The majority of published data is with gemcitabine and cisplatin [14,[19][20][21][22], although there are also published studies of gemcitabine and carboplatin [23][24][25][26][27][28], vinorelbine [29], and triplet therapy with paclitaxel and a platinum agent [30][31][32]. Most studies used two to three cycles of induction.…”

“…In studies evaluating the combination of gemcitabine and carboplatin administered before radiation therapy [23][24][25][26][27][28], the gemcitabine doses have ranged from 1000 to 1250 mg/m 2 on days 1 and 8 with the carboplatin dose ranging from AUC of 5.0 to 5.2 on day 1 every 21 days. Response rates ranged from 30% to 65%, which were similar to those in the gemcitabine with cisplatin studies.…”