494 Penile Lengthening with Porcine Small Intestinal Submucosa Grafting in Peyronie’s Disease Treatment: Long-term Surgical Outcomes, Patients Satisfaction and Dissatisfaction Predictors.

Morgado, Afonso; Tomada, Nuno

doi:10.1016/j.jsxm.2018.04.401

Cited by 3 publications

(22 citation statements)

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“…In our series with porcine dermal graft, we found similar percentages of de‐novo ED (47.4%), with lower decrease of sensitivity (42.1%) and penile rigidity (36.8%), and a longer follow‐up (85 vs. 49.6 months) but higher rates of reported penile shortening (78.9%). Our results appear to be similar or better than the ones obtained with SIS 8,18 with, to date, the longest follow‐up after surgery available in literature.…”

Section: Discussionsupporting

confidence: 85%

“…First, literature evidences for porcine dermal grafts in PD are lacking. Morgado et al 8 in their series with SIS reported penile shortening, hypoestesia and diminished rigidity in 65.5%, 56.3%, and 43.8% of cases respectively, with 53.8% of de‐novo ED after a mean follow‐up time of 49.6 months. In our series with porcine dermal graft, we found similar percentages of de‐novo ED (47.4%), with lower decrease of sensitivity (42.1%) and penile rigidity (36.8%), and a longer follow‐up (85 vs. 49.6 months) but higher rates of reported penile shortening (78.9%).…”

Section: Discussionmentioning

confidence: 92%

“…Despite the recent raising of not surgical treatment of Peyronie’s disease, such as collagenase clostridium injections, 2,15,16 surgical intervention with PEG remains the mainstay for patients with severe penile curvature or hourglass deformations 3 . Various type of grafts have been used for this kind of surgery: autologous grafts, such as veins, 17 albuginea, 6 or buccal mucosa 5 which are affected by the need of an additional incision (and possible complications) in order to retrieve the graft, 10,12 and xenografts, such as porcine small intestine submucosa, 8 bovine pericardium, 11 and hemostatic grafts, 9 which have the advantage of being “off‐the‐shelf” products that do not need surgical retrieval and can be directly sewn into albugineal defects 3,12 . However, there is still no clear evidence about which graft is the optimal choice in case of PEG.…”

Section: Discussionmentioning

confidence: 99%

“…For long‐term evaluation of surgical outcomes, multi‐disciplinary questionnaires used by Morgado et al 8 were administered by phone interview, always performed by the same physician. Questionnaire was composed by a first part regarding mainly surgical outcomes, a second composed by EDITS questionnaire (Erectile Dysfunction Inventory of Treatment Satisfaction), 13 and a third part based on complementary satisfaction questionnaire.…”

Section: Methodsmentioning

confidence: 99%

“…This kind of surgery aims at straightening by recovering penile length through incision/excision on the “short” side of the curvature, with a higher risk of post‐operative erectile dysfunction (ED) compared to penile shortening techniques 4 . Over the past decades, various type of grafts, both allografts 5–7 and xenografts, 8–11 have been used to cover albugineal defects after plaque excision 3,12 but none of these proved superior compared to others, in terms of surgical and functional outcomes 3,12 . The aim of our study was to compare two different types of xenograft, porcine dermal matrix and bovine pericardium matrix, used to cover albugineal defects in PEG for PD, by assessing functional outcomes and patient’s satisfaction after surgery.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term outcomes after plaque incision and grafting for Peyronie’s disease: comparison of porcine dermal and bovine pericardium grafts

Fiorillo¹,

Droghetti²,

Palmisano³

et al. 2020

Andrology

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Background Plaque incision and grafting (PEG) is one of the mainstays in surgical therapy for severe penile curvature in Peyronie’s disease (PD). Different kinds of grafts are available for covering albugineal defects during PEG, both allografts and xenografts. However, to date, none of these proved superior to others. Objectives To compare two different types of xenograft, porcine dermal matrix and bovine pericardium matrix in PEG for PD. Materials and methods From 2010 to 2019, 63 patients with PD underwent PEG, using porcine dermal (n = 25; Group 1) and bovine pericardium (n = 38; Group 2) grafts. Long‐term outcomes were evaluated through multi‐disciplinary questionnaires administration by phone interview. The following items were considered: correction of penile bending, quality of erection, intercourse ability, penile shortening, and sensitiveness. Overall satisfaction and impact of surgery on sexual activity and quality of life were also investigated. Results Plaque median (IQR) size was 29 (22‐33) mm and was smaller in Group 1 (27.5 vs. 31 mm; P = .03). Complete follow‐up data were available for 53 patients (84%). Considering post‐operative outcomes, no differences were found when considering ED rates, penile shortening, sensitiveness, complications, and penile straightening (all P > .1). Patients in Group 2 were more likely to have palpable penile nodules at follow‐up (20.6 vs. 0%; P = .03). However, patient’s post‐operative sexual life satisfaction was consistent between the two groups, with just 1 (5.3) and 8 (23.5) patients in Group 1 and 2 respectively referring a worsening in sexual life satisfaction (P = 0.2). At follow‐up, 84.9% of patients that would still undergo surgery for PD, with no statistical difference between the two groups (P = .4). Conclusions Corporoplasty with PEG is an effective treatment for men with PD. Porcine dermal and bovine pericardium xenografts seem to have similar long‐term outcomes.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Long‐term outcomes after plaque incision and grafting for Peyronie’s disease: comparison of porcine dermal and bovine pericardium grafts

Fiorillo¹,

Droghetti²,

Palmisano³

et al. 2020

Andrology

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A decade of grafting techniques as a sole treatment for Peyronie’s disease

2020

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Background Peyronie's disease (PD) can be a cosmetically and functionally devastating condition. Surgical approaches have been proposed in the chronic stages of PD as plication or plaque incision/excision with grafting to preserve penile size in complex cases. Although several surgeons nowadays are inclined toward the utilization of non‐autologous grafts owing to the ease of their preparation and availability, synthetic graft procedures still await more technical improvements and supporting evidence before their consideration for standard care. Objectives In this review, our goal is to facilitate an insight into the most promising grafting materials used for the management of PD and techniques associated. Materials and methods A PubMed review was conducted for all the studies on our topic within the past ten years (January 2009 until December 2019). The outcome parameters we documented and compared comprised of operative time, follow‐up time, postoperative penile cosmesis and function, and, finally, overall patient satisfaction related to each technique. Results Our search yielded 23 English‐written original study articles in addition to a single case report on the various grafting techniques utilized as the sole treatment for PD, each demonstrating different outcomes and points of comparison. Conclusion A successful grafting procedure for PD requires an appropriately tailored surgical modality and an experienced surgeon. Nevertheless, proper preoperative patient counseling on all aspects of his condition and opted treatment modality while setting clear and realistic expectations remains key for overall patient satisfaction.

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Non‐invasive and surgical penile enhancement interventions for aesthetic or therapeutic purposes: a systematic review

et al. 2020

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Objective To systematically review the literature in order to investigate the efficacy and safety of surgical and non‐invasive penile enhancement procedures for aesthetic and therapeutic purposes. Methods A systematic search for papers investigating penile enhancement procedures was performed using the MEDLINE database. Articles published from January 2010 to December 2019, written in English, including >10 cases, and reporting objective length and/or girth outcomes, were included. Studies without primary data and conference abstracts were excluded. The main outcome measure was objective length and/or girth improvement. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. Results Out of 220 unique records, a total of 57 were reviewed. Eighteen studies assessed interventions for penile enhancement in 1764 healthy men complaining of small penis. Thirty‐nine studies investigated 2587 men with concomitant pathologies consisting mostly of Peyronie's disease and erectile dysfunction. Twenty‐five studies evaluated non‐invasive interventions and 32 studies assessed surgical interventions, for a total of 2192 and 2159 men, respectively. Non‐invasive interventions, including traction therapies and injection of fillers, were safe and mostly efficacious, whereas surgical interventions were associated with minor complications and mostly increased penile dimensions and/or corrected penile curvature. Overall, the quality of studies was low, and standardized criteria to evaluate and report efficacy and safety of procedures, as well as patient satisfaction, were missing. Conclusion The quality of the studies on penile enhancement procedures published in the last decade is still low. This prevents us from establishing recommendations based on scientific evidence regarding the efficacy and safety of interventions that are performed to increase the penis size for aesthetic or therapeutic indications.

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494 Penile Lengthening with Porcine Small Intestinal Submucosa Grafting in Peyronie’s Disease Treatment: Long-term Surgical Outcomes, Patients Satisfaction and Dissatisfaction Predictors.

Cited by 3 publications

References 0 publications

Long‐term outcomes after plaque incision and grafting for Peyronie’s disease: comparison of porcine dermal and bovine pericardium grafts

Long‐term outcomes after plaque incision and grafting for Peyronie’s disease: comparison of porcine dermal and bovine pericardium grafts

A decade of grafting techniques as a sole treatment for Peyronie’s disease

Non‐invasive and surgical penile enhancement interventions for aesthetic or therapeutic purposes: a systematic review

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