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Abstract

To solve the problem of low drug availability in the body, acyclovir was fabricated into biodegradable gelatin nanoparticles by stepwise two-times desolvation method where gelatin was used as biodegradable polymer and glutaraldehyde was utilized as a cross-linking agent. Optimization was conceded by design expert computational application whereby the outcome of gelatin polymer concentration (X1) and glutaraldehyde-crosslinking agent (X2) were studied on particle size (Y1), zeta potential (Y2), and entrapment efficiency (Y3). The drug-loaded gelatin nanoparticle formulations were characterized by particle size, surface charge, and entrapment efficiency. ANOVA studies also evaluated drug-loaded gelatin nanoparticles. The optimized formulation (F9) of 0.8% gelatin polymer (X1) and 250 μl of glutaraldehyde-crosslinking agent (X2) containing acyclovir: gelatin ratio of 1:8, which showed a particle size, zeta potential and maximum entrapment efficiency of 139.87 nm, -32.67mv and 91.23% respectively.INTRODUCTION: Antiviral drugs can be passed down to deal with an ailment as a therapeutic approach, to save from contamination as a prophylactic strategy, or to save from disorder as a preemptive approach 1 . The oral drug availability of acyclovir is terrible in the body, with only 15%-30% of the oral formulations being absorbed 2 .Nanoparticles have emerged as an extra specialty within the biopharmaceuticals industry because of their sizable wonderful residences 3 . Essentially, they have a substantial surface-area-to-volume ratio, which is extremely useful in a drug shipping context because it means that the drug is more likely to interact with the target region and achieve its desired effect 4 .