4CMenB Breadth of Immune Response, Immunogenicity, and Safety: Results From a Phase 3 Randomized, Controlled, Observer Blind Study in Adolescents and Young Adults
Terry Nolan,
Chiranjiwi Bhusal,
Jiří Beran
et al.
Abstract:Background
Meningococcal serogroup B (MenB) strains are highly diverse. Breadth of immune response for the MenB vaccine, 4CMenB, administered at 0-2, 0-6, or 0-2-6 months, was demonstrated by endogenous complement-human serum bactericidal antibody (enc-hSBA) assay against an epidemiologically-relevant panel of 110 MenB strains.
Methods
In a phase 3 trial, 3651 healthy 10–25 year-old participants were randomized 5:5:9:1 to rec… Show more
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