4D imaging of fetal right ventricle—feasibility study and a review of the literature

Abstract

Functional analysis of the fetal cardiovascular system is crucial for the assessment of fetal condition. Evaluation of the right ventricle with standard 2D echocardiography is challenging due to its complex geometry and irregular muscle fibers arrangement. Software package TOMTEC 4D RV-Function is an analysis tool which allows assessment of right ventricular function based on volumetric measurements and myocardial deformation. The aim of this study was to determine the feasibility of this method in fetal echocardiography. The retrospective study was conducted in the high-flow Referral Center for Fetal Cardiology. We recorded 4D echocardiographic sequences of 46 fetuses with normal hearts. Following parameters were calculated: end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF), right ventricle longitudinal free-wall (RVLS free-wall) and septal strain (RVLS septum). Tei index was calculated as a standard measure or RV function for comparison. 4D assessment was feasible in 38 out of 46 fetuses (83%). RV volumetric parameters—EDV, ESV and SV—increased exponentially with gestational age. Functional parameters—RV Tei index, EF and strains—were independent of gestational age. Mean EF was 45.2% (± 6%), RV free-wall strain was − 21.2% and RV septal strain was − 21.5%. There was a statistically significant correlation between septal and free-wall strains (r = 0.51, p = 0.001) as well as between EF and RV free-wall strain (r = − 0.41, p = 0.011). 4D RV assessment is feasible in most fetuses. Its clinical application should be further investigated in larger prospective studies.

Utility of Fetal Cardiac Resonance Imaging in Prenatal Clinical Practice: Current State of the Art

“…Joshua et al [32] depicted fetal CMR as a promising tool for 3D representation of the fetal heart in a workflow of slice-volume registration and post-processing volume reconstruction using a dedicated software. Motion-compensated cine CMR sequences have the potential to measure ventricular volumes and track longitudinal ventricular growth in this setting [37,38]. Reconstructions confirm that correct spatial and temporal features are reliably visualized, suggesting that CMR acquisition and framework reconstruction has the potential for volumetric fetal heart assessment [39,40].…”