4D-Imaging of the Lung: Reproducibility of Lesion Size and Displacement on Helical CT, MRI, and Cone Beam CT in a Ventilated Ex Vivo System

Biederer, J.; Dinkel, Julien; Remmert, Gregor; Jetter, Siri; Nill, Simeon; Moser, T.; Bendl, Rolf; Thierfelder, C; Fabel, M.; Oelfke, Uwe; Bock, Michael; Plathow, Christian; Bolte, Hendrik; Welzel, Thomas; Hoffmann, B.; Hartmann, G.; Schlegel, Wolfgang; Debus, Jürgen; Heller, Martin; Kauczor, Hans Ulrich

doi:10.1016/j.ijrobp.2008.09.014

Cited by 40 publications

(37 citation statements)

References 29 publications

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“…In a phantom study, the consistency of the estimated size of lung lesions between CBCT and CT scan was reported without significant variability. 36 Nevertheless, based on the findings reported here, CBCTs performed as part of routine care may be used to evaluate tumour changes and to predict treatment efficacy early. CBCT lung lesion variations were evaluated using a level/window suggested by Altorjai et al 16 These authors analyzed the interobserver and intra observer target variations on CBCT images compared with CT-based delineation in case of Stage I-II NSCLC or lung metastases SABR.…”

Section: Discussionmentioning

confidence: 92%

Cone-beam computed tomography in lung stereotactic ablative radiation therapy: predictive parameters of early response

Mazzola

Fiorentino

Ricchetti

et al. 2016

BJR

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Section: Discussionmentioning

confidence: 92%

Cone-beam computed tomography in lung stereotactic ablative radiation therapy: predictive parameters of early response

Mazzola

Fiorentino

Ricchetti

et al. 2016

BJR

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“…In addition, it may also be due to tumour progression. Biederer et al 21 found that CBCT volumes from a phantom-based study were significantly larger (up to 7%) than on the planning scan. In our study, two different CT-based imaging methods were used.…”

Section: Discussionmentioning

confidence: 99%

“…This variation was higher in the small volumes included in the study. 21 The benefits of using CBCT are its relatively short acquisition time and availability for patients in a treatment set-up position. If used in the ART process, no additional dose to the patient would be required as this is already acquired for the purposes of set-up.…”

Section: Discussionmentioning

confidence: 99%

An assessment of cone beam CT in the adaptive radiotherapy planning process for non-small-cell lung cancer patients

Duffton

Harrow

McJury

2016

BJR

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Objective: To investigate the potential use of cone beam CT (CBCT) in adaptive radiotherapy (ART) planning process for non-small-cell lung cancer (NSCLC). Methods: 17 retrospective patients with NSCLC Stage T1-T4, who had completed a course of radiotherapy with weekly CBCT imaging were selected for the study. The patients had been delineated and planned for threedimensional (3D) conformal treatment (prescription: 55 Gy in 20 fractions) based on free-breathing fourdimensional CT data. Of these initial 17 patients, 12 had full quantitative data on gross tumour volume (GTV) position and volume throughout treatment. GTV delineation was carried out on weekly CBCT by a clinical oncologist. For each patient, mean percentage change in GTV and centre of mass (COM) displacement (based on 3D vectors) were calculated throughout treatment. Volume overlap between GTVs was calculated. Correlation of the COM displacement and planning GTV (pGTV) was assessed. A linear mixed model with patients as random effects was fitted to the data to assess potential benefit from using ART for these patients. Results: Comparison of CBCT-based GTV acquired prior to Fraction 1 (cbctGTV1) to pGTV showed mean 20 6 19%

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“…A study directly compared 4D CT, 4D MR imaging, and cone beam CT (CBCT) and demonstrated that lesion sizes were exactly reproduced with 4D CT but overestimated on 4D MRI and CBCT with a larger variability due to limited temporal and spatial resolution (Biederer et al 2009). In addition, all 4D modalities underestimate lesion displacement (Biederer et al 2009).…”

Section: Mr Assessment Of Respiratory Tumor Motionmentioning

confidence: 99%

“…In addition, all 4D modalities underestimate lesion displacement (Biederer et al 2009). In addition, another study demonstrated that this technique was considered as a promising tool to analyze complex breathing patterns in patients with lung tumors and to use in planning of radiotherapy to account for individual tumor motion ).…”

Section: Mr Assessment Of Respiratory Tumor Motionmentioning

confidence: 99%

Lung Cancer

Ohno¹,

Koyama²,

Dinkel³

2016

MRI of the Lung

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Since the publication of the Radiologic Diagnostic Oncology Group Report (RDOG) in 1991, the clinical application of pulmonary magnetic resonance (MR) imaging to patients with lung cancer has been limited. MDCT has been much more widely available for staging of lung cancer in clinical situations. Traditionally, FDG-PET or PET/CT is the only modality that reveals biological glucose metabolism of lung cancer, and ventilation and/or perfusion scintigraphy is the only modality that demonstrates pulmonary function. However, recent advances of MR systems and utilization of contrast media make it possible to overcome the limitation of chest MR imaging. Therefore, in the last years, several investigators have demonstrated the significant comprehensive potential of MR imaging to substitute for MDCT and nuclear medicine examinations in lung cancer staging. Currently, MR imaging in lung cancer patients can be applied for (1) detection of pulmonary nodules, (2) characterization of solitary pulmonary nodules, and (3) assessment of TNM classification in routine clinical practice. We believe that further basic studies, as well as clinical applications of newer MR techniques, will play an important role in the future management of patients with lung cancer including MRI.

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4D-Imaging of the Lung: Reproducibility of Lesion Size and Displacement on Helical CT, MRI, and Cone Beam CT in a Ventilated Ex Vivo System

Cited by 40 publications

References 29 publications

Cone-beam computed tomography in lung stereotactic ablative radiation therapy: predictive parameters of early response

Cone-beam computed tomography in lung stereotactic ablative radiation therapy: predictive parameters of early response

An assessment of cone beam CT in the adaptive radiotherapy planning process for non-small-cell lung cancer patients

Lung Cancer

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