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Abderrahim, E.; Zammouri, A.; Bacha, Mohamed Mongi; Ounissi, M.; Gargah, Tahar; Hedri, H.; Slama, R; Bardi, R.; Chébil, Mohamed; Abdallah, T. Ben

doi:10.6002/ect.mesot2016.o66

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…In the postoperative period, there were 434 cases of acute tubular necrosis across 6 studies [17,18,23,26,36,43], and a total of 2248 post-op infections were recorded in 11 studies [15, 17-19, 23, 25-27, 33, 41, 43], totalling 11.36% of all patients in the studies reviewed. Bacterial infections were seen in 30.56% of all patients, which were the most significant cause of post-op infection of known cause, with viral infections (seen in 13.56% of patients) and tuberculosis (in 4.75% of patients) making up the rest.…”

Section: Complications and Managementmentioning

confidence: 99%

A Scoping Review of Kidney Transplantation in Africa: How Far have We Come?

Davis,

Zubair,

Igbokwe

et al. 2023

World j. surg.

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Introduction Kidney transplantation is a life‐saving treatment for end‐stage kidney disease (ESKD) patients. However, access to this treatment in Africa lags behind other regions, leading to significant disparities in care. We aimed to analyse the indications, demographics, and outcomes of kidney transplantation in Africa. Method We conducted a systematic review of studies from PubMed, Google Scholar, and African Journal Online using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. We pooled and analysed data on procedure type, graft outcomes, donor type, prophylaxis, post‐operative complications, and survival from 33 eligible studies. Result The most common causes of ESKD requiring transplantation were glomerulonephritis and nephroangiosclerosis. Open nephrectomy was the predominant surgical approach (95%). Living donors accounted for 56.3% (4221) of all donors, with 68.5% being related to the recipient. Cadaveric donors accounted for 43.7% (3280) of transplants. Graft rejection was the most common surgical complication (39.44%), and 60.49% of patients developed hypertension in the follow‐up period. Conclusion Our study highlights the potential of kidney transplantation to improve the lives of ESKD patients in Africa. However, further research and infrastructure development are necessary to make this treatment more widespread and successful.

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Section: Complications and Managementmentioning

confidence: 99%

A Scoping Review of Kidney Transplantation in Africa: How Far have We Come?

Davis,

Zubair,

Igbokwe

et al. 2023

World j. surg.

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Outcomes and challenges of a kidney transplant programme at Groote Schuur Hospital, Cape Town: A South African perspective

et al. 2019

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IntroductionAccess to dialysis and transplantation in the developing world remains limited. Therefore, optimising renal allograft survival is essential. This study aimed to evaluate clinical outcomes and identify poor prognostic factors in the renal transplant programme at Groote Schuur Hospital [GSH], Cape Town. MethodData were collected on all patients who underwent a kidney transplant at GSH from 1st July 2010 to the 30 June 2015. Analyses were performed to assess baseline characteristics, graft and patient survival, as well as predictors of poor outcome. Results198 patients were transplanted. The mean age was 38 +/- 10.5 years, 127 (64.1%) were male, and 86 (43.4%) were of African ethnicity. Deceased donor organs were used for 130 (66.7%) patients and living donors for 65 (33.3%). There were > 5 HLA mismatches in 58.9% of transplants. Sepsis was the commonest cause of death and delayed graft function [DGF] occurred in 41 (21.4%) recipients. Patient survival was 90.4% at 1 year and 83.1% at 5 years. Graft survival was 89.4% at 1 year and 80.0% at 5 years. DGF (HR 2.83 (1.12–7.19), p value = 0.028) and recipient age > 40 years (HR 3.12 (1.26–7.77), p value = 0.014) were predictors of death.ConclusionDespite the high infectious burden, stratified immunosuppression and limited tissue typing this study reports encouraging results from a resource constrained transplant programme in South Africa. Renal transplantation is critical to improve access to treatment of end stage kidney disease where access to dialysis is limited.

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Kidney Transplant in Low Resources Countries; 6 Years of Successes and Challenges at Benjamin Mkapa Hospital, Tanzania

Shija,

Makubi,

Chandika

et al. 2024

Preprint

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Background Kidney Ttransplant (KT) is the best therapy for patients with Chronic Kidney Disease (CKD). It is advanced services involving multi discipline and highly skilled personnel, conducive infrastructure and sustainable availability of immunosuppressive drugs and consumables. Set-up of KT at Benjamin Mkapa Hospital (BMH) Tanzania in 2018 in collaboration with Shonan Kamakura General Hospital and Tokyo Women’s Medical University from Japan, was of reasonable success despite the challenges encountered. In this review, our experiences, success, challenges and project’s sustainability are discussed. Methodology This was a review study of the methods used to set-up a KT in Tanzania with incorporation of patient data from March, 2018 to July,2024 for 37 transplant recipients. Data was analysed using the SPSS version 27 to obtain the mean and proportions and for patient and gaft survival rate a Kaplan Meir survival curve analysis was applied. Results Succefully a KT was set by BMH in collaboration with Shonan Kamakura General Hospital and Tokyo Women’s Medical University from Japan and 11 medical personnel were trained. Challenges were lack of trained personnel, unreliable supply of medical supplies and immunosuppressive drugs in the local market, lack of fund and shortage of kidney donors. A total of 37 out of 40 patients who have been transplanted were analyzed. The recipients were 73% male and 27% female and their mean age was 47.98 ± 10.81 years. Majority (84%) of kidney donors were blood related to the recipients and 16% spouses of recipients. Hypertension was the leading cause of ESRD with 45% followed by diabetes of 32.5%. Graft survival rates at 1, 3, and 5 years were 90%, 85% and 83% respectively and patient's survival rates at 1, 3, and 5 years was 98.5%, 90% and 85.5% respectively. Conclusion Benjamin Mkapa Hospital has successful sustained KT program by local team after training and mentorship by Japanese experts. Outcomes at 1, 3 and 5 of recipients were good and similar to those in developed countries. The Hospital has demonstrated unique experience in establishing and sustaining KT services in the past 6 years signifying that low income countries can establish kidney transplant program.

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Cited by 4 publications

References 25 publications

A Scoping Review of Kidney Transplantation in Africa: How Far have We Come?

A Scoping Review of Kidney Transplantation in Africa: How Far have We Come?

Outcomes and challenges of a kidney transplant programme at Groote Schuur Hospital, Cape Town: A South African perspective

Kidney Transplant in Low Resources Countries; 6 Years of Successes and Challenges at Benjamin Mkapa Hospital, Tanzania

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