“…The influence of the size of the parameter variation will be illustrated below by considering the largest fourth-order mixed and, respectively, unmixed sensitivities, namely, (i) the largest fourth-order unmixed relative sensitivity S (4) = 2.720 × 10 6 for isotope #6 ( 1 H) of the PERP benchmark and (ii) the largest fourth-order mixed relative sensitivity S (4) σ 30 t,6 , σ 30 t,6 , σ 30 t,6 , σ 30 t,5 = 2.279 × 10 5 , for the leakage response with respect to the microscopic total cross-sections for group 30 of isotopes #5 ( 12 C) and #6 ( 1 H). The exact values for these sensitivities were computed [22] using the software package the "fourth-order SENS" [34], which computes the first-order through the fourth-order sensitivities of the PERP leakage response with respect to model parameters using the "Fourth-Order Comprehensive Adjoint Sensitivity Analysis Methodology" (fourth-CASAM). On the other hand, the finite difference formula that has been used for computing these sensitivities is reproduced below:…”