An ultralow power CMOS voltage reference for body implantable devices is presented in this paper. The circuit core consists of only regular threshold voltage PMOS transistors, thus leading to a very reduced output voltage dispersion, defined as ∕ , and extremely low power consumption. A mathematical model of the generated reference voltage was obtained by solving circuit equations, and its numerical solution has been validated by extensive electrical simulations using a commercial circuit simulator. The proposed solution incorporates a passive RC low-pass filter, to enhance power supply rejection (PSR) over a wide frequency range, and a speed-up section, to accelerate the switching-on of the circuit. The prototype was implemented in 0.18 m standard CMOS technology and is able to operate with supply voltages ranging from 0.7 to 1.8 V providing a measured output voltage value of 584.2 mV at the target temperature of 36 • C. The measured ∕ dispersion of the reference voltage generated is 0.65% without the need of trimming. At the minimum supply of 0.7 V, the experimental power consumption is 64.5 pW, while the measured PSR is kept below -60 dB from DC up to the MHz frequency range. KEYWORDS design methodology, picowatt, subthreshold, trim-free, ultralow power, voltage reference Int J Circ Theor Appl. 2019;47:991-1005.wileyonlinelibrary.com/journal/cta