5-Amino-4-imidazolecarboxaimide riboside raises adenosine in perfused hypoxic rat heart

Oei, H H; Burrier, Althea; Jeng, Arco Y.

doi:10.1016/0014-2999(91)90827-d

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…Nonetheless, these experiments are limited by the non-specificity of AICAR. This compound has other non-AMPK mediated effects, including stimulation of adenosine receptors (Oei et al, 1991) and inhibition of gluconeogenic enzymes (Vincent et al, 1991). In addition, in vivo AICAR administration causes a whole host of systemic metabolic and hormonal alterations that indirectly could affect mTOR signaling, including lowering of plasma glucose and insulin concentration and increasing lactic and uric acid levels (Aschenbach et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

Verdijk²,

Sakamoto

et al. 2012

Mechanisms of Ageing and Development

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AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. Older men had decreased AMPKα2 activity and lower phosphorylation of AMPK and its downstream signaling substrate acetyl-CoA carboxylase (ACC). mTOR phosphylation also was reduced in muscle from older men. Exercise training increased AMPKα1 activity in older men, however, AMPKα2 activity, and the phosphorylation of AMPK, ACC and mTOR, were not affected. In conclusion, older men have alterations in the AMPK-ACC and mTOR pathways in muscle. In addition, prolonged resistance type exercise training induces an isoform-selective up regulation of AMPK activity.

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Section: Discussionmentioning

confidence: 99%

Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

Verdijk²,

Sakamoto

et al. 2012

Mechanisms of Ageing and Development

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Acadesine: Prototype adenosine regulating agent for treating myocardial ischemia‐reperfusion injury

Mullane¹,

Young²

1993

Drug Development Research

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Acadesine is an adenosine regulating agent currently being developed for treatment of ischemia-reperfusion injury in the setting of cardiac surgery. While the cardioprotective effects of adenosine are well recognized, the intrinsic hemodynamic and cardiac effects of adenosine limit its potential usefulness as a therapeutic agent. In contrast, acadesine has been shown to elevate endogenous levels of adenosine during periods of ischemia without exhibiting systemic hemodynamic actions. The site-specific and event-specific mechanism of action thus provides cardioprotection without the adverse sequelae commonly observed with adenosine. This review describes the pertinent literature which establishes acadesine's action as an adenosine regulating agent, and discusses past and recent studies which focus on the cardioprotective actions of acadesine. These studies include in vitro and in vivo models of regional and global ischemia, and models of cardiac surgery. Aspects of dose-response, timing of administration, and pharmacokinetics of acadesine are described which reconcile prior controversy regarding acadesine's cardioprotective actions. These studies, taken together, demonstrate that acadesine is the prototype of a new class of adenosine regulating agents useful as therapy for cardiac ischemia. o 1993 WiIey-Liss, Inc.

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Cardioprotection with Adenosine, Inosine and Hypoxanthine

Jong

Tavenier

Lee

et al. 1996

Developments in Cardiovascular Medicine

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5-Amino-4-imidazolecarboxaimide riboside raises adenosine in perfused hypoxic rat heart

Cited by 4 publications

References 22 publications

Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

Acadesine: Prototype adenosine regulating agent for treating myocardial ischemia‐reperfusion injury

Cardioprotection with Adenosine, Inosine and Hypoxanthine

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