5-aminolevulinic acid and sodium ferrous citrate decreased cell viability of gastric cancer cells by enhanced ROS generation through improving COX activity

Suprihadi, Arif; Pustimbara, Anantya; Ogura, Shun‐ichiro

doi:10.1016/j.pdpdt.2022.103055

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…Sodium ferrous citrate (SFC) is commonly used an iron source in various studies [ 24 , 25 ]. In order to induce more conversion of PpIX into heme, we evaluated the effect of co-administration of ALA and SFC on ACE2 expression.…”

Section: Resultsmentioning

confidence: 99%

Suppression of angiotensin converting enzyme 2, a host receptor for SARS-CoV-2 infection, using 5-aminolevulinic acid in vitro

et al. 2023

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Angiotensin converting enzyme 2 (ACE2), an entry receptor found on the surface of host cells, is believed to be detrimental to the infectious capability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Scientists have been working on finding a cure since its outbreak with limited success. In this study, we evaluated the potential of 5-aminolevulinic acid hydrochloride (ALA) in suppressing ACE2 expression of host cells. ACE2 expression and the production of intracellular porphyrins following ALA administration were carried out. We observed the reduction of ACE2 expression and intracellular porphyrins following ALA administration. ALA suppressed the ACE2 expression in host cells which might prevent binding of SARS-CoV-2 to host cells. Co-administration of ALA and sodium ferrous citrate (SFC) resulted in a further decrease in ACE2 expression and increase in intracellular heme level. This suggests that the suppression of ACE2 expression by ALA might occur through heme production. We found that the inhibition of heme oxygenase-1 (HO-1), which is involved in heme degradation, also resulted in decrease in ACE2 expression, suggesting a potential role of HO-1 in suppressing ACE2 as well. In conclusion, we speculate that ALA, together with SFC administration, might serve as a potential therapeutic approach in reducing SARS-CoV-2 infectivity through suppression of ACE2 expression.

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Section: Resultsmentioning

confidence: 99%

Suppression of angiotensin converting enzyme 2, a host receptor for SARS-CoV-2 infection, using 5-aminolevulinic acid in vitro

et al. 2023

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“…165,166 The leading characteristic of ROS is the high reactivity, which has led to the existence of diverse ROSmediated reactions within biological environments. 167 ROS have abundant intracellular sources including NADPH oxidase, 168 xanthine oxidases, cyclooxygenases, 169 and mitochondria 170 among others. Apart from endogenous ROS sources, many exogenous sources such as agent ionization and radiation can further stimulate ROS generation.…”

Section: Ros-responsive Cpt Prodrug Nanomedicinesmentioning

confidence: 99%

Camptothecin-based prodrug nanomedicines for cancer therapy

Zhang,

Yu,

Guo

et al. 2023

Nanoscale

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“…The combination of 5-ALA and ferrous sodium citrate (SFC) resulted in the selective accumulation of PS PpIX and reduced cell viability in a concentration-dependent manner. 5-ALA-SFC enhanced ROS generation and reduced cell viability of the human gastric cancer line MKN45 [56]. Colorectal cancer (CRC) has been reported as the second leading cause of tumor deaths worldwide.…”

Section: Ros Production By 5-ala-pdtmentioning

confidence: 99%

Reactive Oxygen Species Produced by 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Cancer

Pignatelli,

Umme,

D’Antonio

et al. 2023

IJMS

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Cancer is the leading cause of death worldwide and several anticancer therapies take advantage of the ability of reactive oxygen species to kill cancer cells. Added to this is the ancient hypothesis that light alone can be used to kill cancer cells. 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) is a therapeutic option for a variety of cutaneous and internal malignancies. PDT uses a photosensitizer that, activated by light in the presence of molecule oxygen, forms ROS, which are responsible for the apoptotic activity of the malignant tissues. 5-ALA is usually used as an endogenous pro-photosensitizer because it is converted to Protoporphyrin IX (PpIX), which enters into the process of heme synthesis and contextually becomes a photosensitizer, radiating a red fluorescent light. In cancer cells, the lack of the ferrochelatase enzyme leads to an accumulation of PpIX and consequently to an increased production of ROS. PDT has the benefit of being administered before or after chemotherapy, radiation, or surgery, without impairing the efficacy of these treatment techniques. Furthermore, sensitivity to PDT is unaffected by the negative effects of chemotherapy or radiation. This review focuses on the studies done so far on 5-ALA-PDT and its efficacy in the treatment of various cancer pathologies.

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5-aminolevulinic acid and sodium ferrous citrate decreased cell viability of gastric cancer cells by enhanced ROS generation through improving COX activity

Cited by 6 publications

References 45 publications

Suppression of angiotensin converting enzyme 2, a host receptor for SARS-CoV-2 infection, using 5-aminolevulinic acid in vitro

Suppression of angiotensin converting enzyme 2, a host receptor for SARS-CoV-2 infection, using 5-aminolevulinic acid in vitro

Camptothecin-based prodrug nanomedicines for cancer therapy

Reactive Oxygen Species Produced by 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Cancer

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