5-Aminolevulinic Acid Imaging of Malignant Glioma

Guan, Li; Rodrigues, Adrian; Kim, Lily; Garcia, César A.; Jain, Shruti; Zhang, Michael; Hayden-Gephart, Melanie

doi:10.1016/j.soc.2022.06.002

Cited by 4 publications

(4 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5‐AminoLA is also obtained from LA and has demonstrated potential for application in agriculture, being non‐toxic to humans and animals and biodegradable, leaving no residue in the environment 15,18 . It has recently been explored for use in the medical field with promising results 19,20 . Although it is a product with a potential application, the full benefit of 5‐aminoLA is still limited by the costs of the process and its mechanism of action, which are not fully explained 15,17 …”

Section: General Aspects Of the Lamentioning

confidence: 99%

“…15,18 It has recently been explored for use in the medical field with promising results. 19,20 Although it is a product with a potential application, the full benefit of 5-aminoLA is still limited by the costs of the process and its mechanism of action, which are not fully explained. 15,17 Levulinic acid has been involved in around 130 pharmaceutical formulations.…”

Section: General Aspects Of the Lamentioning

confidence: 99%

See 1 more Smart Citation

Recent advances, perspectives and challenges on levulinic acid production from residual biomass

Bazoti

Bonatto

Scapini

et al. 2023

Biofuels Bioprod Bioref

View full text Add to dashboard Cite

Over the years, several studies have focused on integrally exploring lignocellulosic biomass to achieve satisfactory yields of different bioproducts and establish economically viable industrial processes. Among the bioproducts, levulinic acid (LA) has emerged as one of the top platform products derived from biomass, mainly owing to its expanding market economic position, which can stimulate viability and attract the attention of investors in the field. Considered a building block because of its versatile intermediate chemical structure, it can be used to synthesize many compounds with applications in fuels, pharmaceutical and cosmetics industries, food additives and solvents. The main synthesis route for obtaining LA is the degradation of cellulose via acid catalysis. In this context, lignocellulosic biomass is a promising and sustainable way of getting LA. Recent research has explored a potential path to full technological development associated with LA from various biomass and different catalysts. In this scenario, a comprehensive review concerning biomass for LA production and the challenges in the synthesis process is proposed. The primary studies conducted over the years and approaches to using and appreciating residual biomass are also discussed. This work also considers the use of technological tools to optimize the production of LA and seeks to contribute sustainable proposals still little explored, such as the intensification of the process and the use of fruit residues in the synthesis of this promising building block.

show abstract

Section: General Aspects Of the Lamentioning

confidence: 99%

Section: General Aspects Of the Lamentioning

confidence: 99%

Recent advances, perspectives and challenges on levulinic acid production from residual biomass

Bazoti

Bonatto

Scapini

et al. 2023

Biofuels Bioprod Bioref

View full text Add to dashboard Cite

show abstract

“…A combined approach might overcome the respective shortcomings of current MRI and fluorescence imaging to achieve accurate resection of glioma. 20 In recent years, nanotechnology has developed rapidly in the biomedical field. Multifunctional nanomaterials with good imaging and therapeutic potential have been developed.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In addition, MRI and intraoperative fluorescence imaging are independent tumor imaging modes, so an integrated multimodal imaging method should be developed. A combined approach might overcome the respective shortcomings of current MRI and fluorescence imaging to achieve accurate resection of glioma …”

Section: Introductionmentioning

confidence: 99%

Multifunctional Self-Assembled DNA Nanospheres for Glioma Fluorescence/Magnetic Resonance Imaging and Therapy

Xu,

Liu,

Shi

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

DNA molecules can form predictable nanostructures through sequence-directed hybridization. In this study, DNA nanospheres were designed for fluorescence/magnetic resonance imaging and drug delivery in glioma-bearing mice. DNA nanospheres were constructed using Y-shaped DNA, linker DNA, and an DNA aptamer through the hybridization of their sticky ends. Linker DNA was assembled by an i-motif sequence with its complementary strand and could cause pH-responsive dissociation of double strands. The DNA aptamer with a sticky end could inhibit the extension of nanospheres to control their size as well as recognize glioma cells. Gd-DOTA, Cy5, and BHQ-3 were modified at specific bases to endow DNA nanospheres with dual imaging capabilities. Doxorubicin was loaded into DNA double strands, which were readily released in acidic environments. In vitro experiments revealed that the multifunctional nanospheres were pHresponsive and showed effective cell uptake and fluorescence and magnetic resonance imaging abilities. As drug carriers, DNA nanospheres increased the potency of doxorubicin against glioma cells. This approach achieved dual imaging and therapeutic effects in xenograft glioma mice by integrating multiple functions and may provide guidance for the surgical resection of glioma and assist with postoperative chemotherapy.

show abstract

Nanoparticles drug delivery for 5-aminolevulinic acid (5-ALA) in photodynamic therapy (PDT) for multiple cancer treatment: a critical review on biosynthesis, detection, and therapeutic applications

Bhattacharya,

Prajapati,

Singh

et al. 2023

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

5-Aminolevulinic Acid Imaging of Malignant Glioma

Cited by 4 publications

References 78 publications

Recent advances, perspectives and challenges on levulinic acid production from residual biomass

Recent advances, perspectives and challenges on levulinic acid production from residual biomass

Multifunctional Self-Assembled DNA Nanospheres for Glioma Fluorescence/Magnetic Resonance Imaging and Therapy

Nanoparticles drug delivery for 5-aminolevulinic acid (5-ALA) in photodynamic therapy (PDT) for multiple cancer treatment: a critical review on biosynthesis, detection, and therapeutic applications

Contact Info

Product

Resources

About