5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis

Reifen, Ram; Nissenkorn, Andreea; Matas, Zippora; Bujanover, Yoram

doi:10.1007/s00535-003-1336-z

Cited by 78 publications

(52 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, Se and vitamin E may prevent the certain types of the oxidative damages produced by infiltrating macrophages and neutrophils within inflamed colon. These considerations are in agreement with opinions of the authors who investigate prophylactic effects of antioxidants against oxidative damage in blood [13,34], liver [39], and colon tissues [14,40].…”

Section: Discussionsupporting

confidence: 85%

Protective Effects of Selenium and Vitamin E Combination on Experimental Colitis in Blood Plasma and Colon of Rats

Bıtıren

Karakılçık

Zerin

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

Ulcerative colitis increases oxidative damage accompanied by production of free oxygen radicals. Selenium (Se) and vitamin E are two natural antioxidants. The present study was undertaken to investigate the possible protective role of Se and vitamin E combination in experimental colitis induced by acetic acid (AA) in rats. This study was carried out on three groups, namely the first (control), the second (experimental colitis group, 2 ml 5% acetic acid), and the third groups (2 ml 5% acetic acid, vitamin E (100 mg/kg body weight (bw)) plus Se (0.2 mg/kg bw)). The activities of catalase (CAT), prolidase (PRS), myeloperoxidase (MPO), total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), total thiol (T-SH) were determined in plasma and colon samples. Macroscopic and microscopic damages in colon were increased by AA treatment (p < 0.01 and p < 0.01, respectively), whereas they were decreased by selenium and vitamin E treatment (p < 0.05 and p < 0.01, respectively). The activities of CAT and PRS in the plasma and colon were significantly affected (p < 0.05 and p < 0.01) by treatment of AA, Se, and vitamin E. MPO activity in colon was increased (p < 0.01) by AA treatment and decreased (p < 0.05) by Se and vitamin E administration. The values of TOS and OSI in plasma were increased (p < 0.5) by AA. The TAC and T-SH in colon were decreased (p < 0.05) by AA and increased (p < 0.05) by Se and vitamin E. Based upon these results, Se and vitamin E may play an important role in preventive indication of the oxidative damage associated by acetic acid caused inflammation.

show abstract

Section: Discussionsupporting

confidence: 85%

Protective Effects of Selenium and Vitamin E Combination on Experimental Colitis in Blood Plasma and Colon of Rats

Bıtıren

Karakılçık

Zerin

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Iron excess resulted in an increased oxidative damage in the liver and thus causing mitochondrial membrane alterations. Lipid peroxidation occurred as shown by MDA increase and could thereby change the fluidity of the inner mitochondrial membrane and subsequent mitochondrial swelling, in agreement with previous results (Reifen et al, 2004;Lafay et al, 2005). Such a damage aff ected especially the liver because it is the major recipient for excessive iron and might indicate a process of iron removal from the liver.…”

Section: Ultrastructural Alterations and Autophagy In Liversupporting

confidence: 89%

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

et al. 2013

View full text Add to dashboard Cite

Lycopene is common in diet and known for its antioxidant activities. However, the impact of lycopene on iron metabolism is poorly investigated. In this study, we hypothesize that lycopene can prevent iron-mediated oxidative stress, proliferation and autophagy in liver and use a rat model of nutritional iron supplementation to confi rm its intervention in these defence mechanisms. We found that iron supplementation induced cell proliferation predominantly in non parenchymal cells compared with hepatocytes, but not apoptosis. In addition, iron was accumulated within the hepatic lysosomes where it triggered autophagy as evidenced by the formation of autophagic vesicles detected by LC3-B staining. Iron supplementation also induced morphologic alterations of the mitochondrial membranes probably due to increased lipid peroxidation as indicated by elevated iron and malondialdehyde concentrations in serum and tissues. Lycopene reduced iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level in the liver and colon and enhancing the total superoxide dismutase activities in serum and tissues. The result suggest that lycopene prevents iron-induced oxidative stress, proliferation and autophagy at both biochemical and histological levels due to its potent free radical scavenging and antioxidant properties.

show abstract

“…There is significant evidence supporting the actions of lycopene as a potent antioxidant, and there are a number of potential mechanisms through which tomato products may reduce the risk for chronic diseases, including common forms of cancer and heart disease [7]. Experimental rodent models suggest that lycopene plays an important role in the modulation of organ injury evoked by inflammatory process [8,9].…”

Section: Introductionmentioning

confidence: 98%

Protective Effects of Lycopene on Cerulein-Induced Experimental Acute Pancreatitis in Rats

Özkan¹,

Akyüz²,

Dulundu³

et al. 2012

Journal of Surgical Research

View full text Add to dashboard Cite

5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis

Cited by 78 publications

References 17 publications

Protective Effects of Selenium and Vitamin E Combination on Experimental Colitis in Blood Plasma and Colon of Rats

Protective Effects of Selenium and Vitamin E Combination on Experimental Colitis in Blood Plasma and Colon of Rats

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

Protective Effects of Lycopene on Cerulein-Induced Experimental Acute Pancreatitis in Rats

Contact Info

Product

Resources

About