5‐Caffeoylquinic acid decreases diet‐induced obesity in rats by modulating <scp>PPARα</scp> and <scp>LXRα</scp> transcription

Huang, Kang; Liang, Xiuci; Zhong, Yingli; He, Wan-yan; Wang, Zheng

doi:10.1002/jsfa.6896

Cited by 108 publications

(79 citation statements)

References 53 publications

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“…This was similar to the results of our group 23 and those of Cho et al 13 who found that CGA improved the body weight, lipid metabolism, and obesity- related hormone levels in obese mice. However, 5-CQA-treated rats showed a significant improvement in these levels.…”

Section: Discussionsupporting

confidence: 92%

Effect of 5-caffeoylquinic acid on the NF-κB signaling pathway, peroxisome proliferator-activated receptor gamma 2, and macrophage infiltration in high-fat diet-fed Sprague–Dawley rat adipose tissue

et al. 2015

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Obesity, considered as a consequence of overnutrition, sustains a low-degree inflammatory state and results in insulin-resistance and type 2 diabetes. Here, we investigated the anti-inflammatory effects of 5-caffeoylquinic acid (5-CQA) in high-fat diet-induced obese rats. Serum interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor-alpha (TNF-α), total cholesterol (TC), triglyceride (TG), and free fatty acid (FFA) levels were determined. Expression of genes related to TG metabolism, macrophage biomarkers, and inflammation was assessed by real-time PCR. Protein expression of NF-κB, PPARγ2, and phosphorylated IκBα was evaluated by western blotting, and the histology of adipose tissue was examined. Supplementation of the rat diet with 5-CQA reduced obesity development, macrophage infiltration, and steatosis. Additionally, 5-CQA decreased the expression of NF-κB and downstream inflammatory cytokines, but increased the expression of PPARγ2, in a dose-dependent manner. Thus, 5-CQA improved obesity and obesity-related metabolic disturbances via PPARγ2 and the NF-κB signaling pathway.

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Section: Discussionsupporting

confidence: 92%

Effect of 5-caffeoylquinic acid on the NF-κB signaling pathway, peroxisome proliferator-activated receptor gamma 2, and macrophage infiltration in high-fat diet-fed Sprague–Dawley rat adipose tissue

et al. 2015

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“…Additionally, CGA was shown to decrease cholesterol via LXR (Huang et al . ). In the present study, no differences were observed in whole fish fat (data not shown) and PPARα expression levels in pyloric caeca or liver were not affected by dietary means.…”

Section: Discussionmentioning

confidence: 97%

Effect of diets low in fish oil and supplemented with chlorogenic acid on fatty acid composition and lipid metabolism in Atlantic salmon (Salmo salarL.)

et al. 2016

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This study aimed to test the use of chlorogenic acid (CGA), a natural antioxidant, which might act improving the retention of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids. Fish were fed one of three experimental diets. A diet with 160 g kg−1 fish oil (FO) and 80 g kg−1 vegetable oil (VO) was used as a positive control with high n‐3 long‐chain polyunsaturated fatty acids (LC)‐PUFA, a diet containing 40 g kg−1 FO and 200 g kg−1 VO was used as a negative control for low n‐3 LC‐PUFA and 1 g kg−1 CGA was added to the negative control diet to test the impact of CGA on n‐3 LC‐PUFA synthesis. The expression of genes involved in PUFA synthesis was upregulated in the liver of fish fed the low n‐3 LC‐PUFA diets. This might be due to the activation of sterol regulatory element‐binding transcription factor 1 (SREBP1) and liver X receptor. Moreover, malondialdehyde concentration tended to decrease, and accumulation of dietary EPA in the liver in relation to diet was observed in fish fed the low n‐3 LC‐PUFA diets. However, the concentration of EPA and DHA was higher in fish fed the positive control diet. The inclusion of 1 g kg−1 CGA did not exert any additional effect on lipid peroxidation, EPA and DHA concentrations or LC‐PUFA metabolism.

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“…Moreover, CGAs contribute to prevent various diseases associated with oxidative stress, as well as cancer, aging, and cardiovascular and neurodegenerative diseases; besides, these substances have promising effects in modulating lipid and glucose metabolism [12][13][14][15]. On the other hand, quantity of CGAs is inversely associated with quality of a coffee cup.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Caffeine and Chlorogenic Acids in Green Coffee by UV/Vis Spectroscopy

Navarra

Moschetti

Guarrasi

et al. 2017

Journal of Chemistry

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A simple method for the simultaneous determination of caffeine and chlorogenic acids content in green coffee was reported. The method was based on the use of UV/Vis absorption. It is relevant that the quantification of both caffeine and chlorogenic acids was performed without their preliminary chemical separation despite their spectral overlap in the range 250-350 nm. Green coffee was extracted with 70% ethanol aqueous solution; then the solution was analyzed by spectroscopy. Quantitative determination was obtained analytically through deconvolution of the absorption spectrum and by applying the Lambert-Beer law. The bands used for the deconvolution were the absorption bands of both caffeine and chlorogenic acids standards. The molar extinction coefficients for caffeine and chlorogenic acid in ethanol solution at 70% were calculated by using the chemical standards; the estimated values were (272 nm) = 12159 ± 97 M −1 cm −1 for caffeine and (330 nm) = 27025 ± 190 M −1 cm −1 for chlorogenic acids molecules, respectively. The estimate of concentration values was in agreement with the one obtained by High Performance Liquid Chromatography quantification. The method is fast and simple and allows us to realize routine controls during the coffee production. In addition, it could be applied on roasted coffee and espresso coffee.

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5‐Caffeoylquinic acid decreases diet‐induced obesity in rats by modulating PPARα and LXRα transcription

Abstract: 5-CQA may improve lipid metabolism disorders by altering the expression of PPARα and LXRα, which are involved in multiple intracellular signalling pathways.

Cited by 108 publications

References 53 publications

Effect of 5-caffeoylquinic acid on the NF-κB signaling pathway, peroxisome proliferator-activated receptor gamma 2, and macrophage infiltration in high-fat diet-fed Sprague–Dawley rat adipose tissue

Effect of 5-caffeoylquinic acid on the NF-κB signaling pathway, peroxisome proliferator-activated receptor gamma 2, and macrophage infiltration in high-fat diet-fed Sprague–Dawley rat adipose tissue

Effect of diets low in fish oil and supplemented with chlorogenic acid on fatty acid composition and lipid metabolism in Atlantic salmon (Salmo salarL.)

Simultaneous Determination of Caffeine and Chlorogenic Acids in Green Coffee by UV/Vis Spectroscopy

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