5 Dyslipoproteinaemia of liver disease

Miller, J P

doi:10.1016/s0950-351x(05)80080-1

Cited by 75 publications

(49 citation statements)

References 106 publications

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“…The abnormal fraction which appeared between the chylomicron and LDL fractions in lipoprotein electrophoresis might be suspected of being lipoprotein X (Lp-X) [47], which has been reported in patients with cholestatic liver diseases [11,33,44], patients with a deficiency of lecithin/cholesterol acyltransferase (LCAT) [16,36,48] and during intravenous infusion of fat emulsions [2,50,51]. Lp-X is a bilayer vesicle of phospholipids (51-66%) and free cholesterol (22-30%) and contains a small amount of proteins essentially including albumin and apoCs but also including apoE and apoAI [2,16,33,35,36,39,44,48].…”

Section: Discussionmentioning

confidence: 99%

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APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins.

et al. 2000

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Syrian hamsters of the APA strain (APA hamsters) have recently been shown to have atheromatous lesions in the aortic arches under diabetic condition induced by a single injection of streptozotocin (SZ). In that model, fatty streaks, which are the initial lesions of atherogenesis, develop by 6 weeks after the injection (WAI). In this study, we evaluated plasma lipid concentrations and lipoprotein profiles in diabetic APA hamsters at 6 WAI to reveal the early stage of atherogenesis clinicopathologically. As a result, by biochemical analysis, hyperglycemic APA hamsters showed signs of hypercholesterolemia and hypertriglyceridemia. Low-density lipoprotein (LDL) cholesterol significantly increased, but high-density lipoprotein (HDL) cholesterol significantly decreased. Agarose gel electrophoresis showed an obvious increase in the fractions of chylomicron, LDL and abnormal lipoprotein. Plasma LDL in diabetic animals was in a state more susceptible to oxidization. In addition, a significant increase in glycated LDL was also found in the diabetic animals by enzyme linked immunosorbent assay (ELISA). Moreover, lipid peroxidation product (4-hydroxynonenal (4 HNE))-adducted proteins and advanced glycation end-products (AGE) were immunohistochemically detected in the foam cells of the fatty streaks. These results revealed that diabetic APA hamsters had hyperlipidemia characterized by increases in chylomicron, LDL and abnormal lipoprotein, and suggested that oxidized LDL and/or glycated LDL might be actively uptaken by macrophages and play an important role in the initial stage of atherogenesis.

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Section: Discussionmentioning

confidence: 99%

“…Lp-X is a bilayer vesicle of phospholipids (51-66%) and free cholesterol (22-30%) and contains a small amount of proteins essentially including albumin and apoCs but also including apoE and apoAI [2,16,33,35,36,39,44,48]. Lp-X is postulated to be related to biliary lipid vesicles, but the mechanism of Lp-X generation remains unclear.…”

Section: Discussionmentioning

confidence: 99%

APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins.

et al. 2000

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“…In physiological circumstances most lipids are initially synthesized in liver and then introduced in the systemic circulation [6]. In the setting of acute or chronic hepatic dysfunction circulating lipids and lipoproteins are altered with respect to quantity as well as electrophoretic mobility and appearance [7].…”

Section: Introductionmentioning

confidence: 99%

Lipid profile in acute viral hepatitis: A study from north eastern India

Bhattacharya¹,

Tomke²,

Saikia³

2016

Int J of Biomed & Adv Res

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Background: Acute viral hepatitis is associated with significant hepatic dysfunction including lipid metabolism. Variations in the serum lipid fractions in acute viral hepatitis due to hepatic injury may serve as prognostic marker for severity of hepat ic injury. Methods: Hospital-based prospective study on acute viral hepatitis. Fifty cases of acute viral hepatitis and 50 age and sex matched controls, (>18 years) were studied. Routine biochemical investigation, hepatotropic viral serology and fasting serum lipid fractions were analysed for changes in patients with acute viral hepatitis. Chi-square test was used for comparing variables. A 'p value' <0.05 was considered statistically significant. Results: Baseline parameters were similar between cases and controls (p>0.05). Jaundice (100%) and high coloured urine (100%) were the commonest presentations. Hepatitis A virus (52%) and Hepatitis E virus (30%) were commonest aetiological agents. Serum cholesterol, triglycerides, low density lipoprotein (LDL) were significantly higher (p<0.01) while high density lipoprotein (HDL) was significantly lower (p<0.01) in acute viral hepatitis compared to controls. There was no statistically significant difference in the levels of very LDL between cases and controls (p>0.05). Complications were seen in 7 (14%) cases with hepatic encephalopathy being the commonest (6%). Serum cholesterol, triglycerides, LDL were significantly higher and HDL was significantly lower in hepatitis with complications compared to uncomplicated hepatitis (p<0.01). Conclusion Acute viral hepatitis leads to significant alterations of serum lipid fractions which may serve as an indicator of severity of liver damage and be helpful in assessing the prognosis of patients with acute viral hepatitis.

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“…Lp-X is characterized by the appearance of stacked discs of 30-70 nm in diameter under the electron microscopy and has a high concentration of free cholesterol (FC) (66%) and phospholipids (PL) (23%). However, it contains fewer core lipids with 3% triglycerides (TG) and 2% cholesteryl esters (CE) (1). Lp-X may have antiatherogenic properties but marked elevation of Lp-X has been reported to produce hyperviscosity syndrome (2).…”

Section: Introductionmentioning

confidence: 99%

A Case of Type 2 Diabetes and Metastatic Liver Cancer Exhibiting Hypercholesterolemia with Abnormal Lipoproteins

et al. 2012

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Although the appearance of abnormal lipoproteins in liver diseases is well known, the precise analyses of abnormal lipoproteins remain elusive. Here, we report a 71-year-old woman with type 2 diabetes whose serum cholesterol levels were elevated to 560 mg/dL over a 4-month period. High-performance liquid chromatography demonstrated the presence of lipoprotein-X and lipoprotein-Y and sigmoid colon cancer and multiple liver metastases were found by colonoscopy and computed tomography. Remission of the primary colon cancer and liver lesions was achieved by chemotherapy with oxaliplatin and fluorouracil and her serum cholesterol went back to basal levels associated with the disappearance of abnormal lipoproteins.

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5 Dyslipoproteinaemia of liver disease

Cited by 75 publications

References 106 publications

APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins.

APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins.

Lipid profile in acute viral hepatitis: A study from north eastern India

A Case of Type 2 Diabetes and Metastatic Liver Cancer Exhibiting Hypercholesterolemia with Abnormal Lipoproteins

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