2023
DOI: 10.1002/ardp.202300217
|View full text |Cite
|
Sign up to set email alerts
|

5‐Fluoro/(trifluoromethoxy)‐2‐indolinone derivatives with anti‐interleukin‐1 activity

Özge Soylu‐Eter,
Zekiye Şeyma Sevinçli,
Betül Ersoy
et al.

Abstract: The pro‐inflammatory cytokine interleukin‐1 (IL‐1) drives the pathogenesis of several inflammatory diseases. Recent studies have revealed that 2‐indolinones can modulate cytokine responses. Therefore, we screened several 2‐indolinone derivatives in preliminary studies to develop agents with anti‐IL‐1 activity. First, the putative efficacies and binding interactions of 2‐indolinones were evaluated by docking studies. Second, previously synthesized 5‐fluoro/(trifluoromethoxy)−1H‐indole‐2,3‐dione 3‐(4‐phenylthios… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
references
References 52 publications
0
0
0
Order By: Relevance