5-Fluorouracil Loaded Chitosan–PVA/Na+MMT Nanocomposite Films for Drug Release and Antimicrobial Activity

Abstract

In the present study, chitosan and polyvinyl alcohol (PVA) were blended with different concentrations of sodium montmorillonite (Na+MMT) clay solution by a solvent casting method. X-ray diffraction and transition electron microscope results show that the film properties are related to the co-existence of Na+MMT intercalation/exfoliation in the blend and the interaction between chitosan–PVA and Na+MMT. 5-Fluorouracil (5-FU) was loaded with chitosan–PVA/Na+MMT nanocomposite films for in vitro drug delivery study. The antimicrobial activity of the chitosan–PVA/Na+MMT films showed significant effect against Salmonella (Gram-negative) and Staphylococcus aureus (Gram-positive), whereas 5-FU encapsulated chitosan–PVA/Na+MMT bio-nanocomposite films did not show any inhibition against bacteria. Our results indicate that combination of a flexible and soft polymeric material with high drug loading ability of a hard inorganic porous material can produce improved control over degradation and drug release. It will be an economically viable method for preparation of advanced drug delivery vehicles and biodegradable implants or scaffolds.

The Synergism of Platinum-Gold Bimetallic Nanoconjugates Enhances 5-Fluorouracil Delivery In Vitro

“…It is often a stand-alone drug for treatment of colorectal cancers, and together with modulators such as leucovorin and oxaliplatin, is the most effective treatment for metastatically advanced colorectal cancers [3]. However, its clinical application has limitations, including dose dependent side effects, rapid metabolism in vivo, short half-life, non-uniform oral absorption, compromised tissue penetration and non-selective biodistribution [4]. To overcome these underlying predicaments, the incorporation of potent biological agents together with metal nanoparticle carriers is rapidly gaining momentum.…”

Adsorption of the anionic dye (Diamond Fast Brown KE) from textile wastewater onto chitosan/montmorillonite nanocomposites

“…The dark lines pointed out the well delaminated nano-montmorillonite layers which were stabilized within the crosslinked polymer matrix, whereas the bright zone reflected the intercalated Chs matrix. Sizes were less than 100 nm, so it could be assumed that both prepared composites were nanocomposite materials [38][39][40].…”

Antioxidant Materials Based on 2D Nanostructures: A Review on Recent Progresses

“…In addition, 2D materials possess unusual electronic, mechanical and optical properties and hence, they can be used as building blocks in a wide range of composites. Concerning the contemporary applications of 2D compounds, they serve as efficient catalysts for water splitting [6][7][8][9][10][11][12][13][14][15] or organic reactions [16][17][18][19][20][21], drug carriers [22][23][24][25][26][27][28][29][30][31], sensors [32][33][34][35][36][37][38][39], materials for energy production and storage [2,15,21,[40][41][42][43][44][45][46][47][48][49] or adsorbers [50]…”