5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy

Valencia-Lazcano, Anai A; Hassan, Dilawar; Pourmadadi, Mehrab; Shamsabadipour, Amin; Behzadmehr, Razieh; Rahdar, Abbas; Medina, Dora Iliana; Díez‐Pascual, Ana M.

doi:10.1016/j.ejmech.2022.114995

Cited by 66 publications

(29 citation statements)

References 74 publications

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“…13 ) and this has given the concept of ‘controlled’ and ‘sustained’ release of drugs [ 112 , 113 ]. Polymeric or liposomal formulations have played significant roles, in targeted delivery of enzymes [ 114 ], anticancer drugs [ 115 , 116 ], and antimicrobial drugs, through ligands at a dedicated rate [ 112 , 117 , 118 ]. As describes previously, entrapment or encapsulation of bioactive molecules requires a cavity or casing to be avoided by reticuloendothelial system or leakage; structural features of polymeric nanocarriers serve the purpose by carrying greater quantity of enzymes, proteins, or even nucleic acids [ 119 ].…”

Section: Therapeutic Applications Of Nanobiotechnologymentioning

confidence: 99%

“…Consequently, co-delivery of drugs or bioactive molecules of totally different purpose and structure (therapeutic agent and imaging) (Fig. 4 ) becomes feasible especially in the field of theranostics, for treating bacterial and viral infections, inflammation, and cancers [ 115 , 116 ]. Co-delivery is very significant as adjuvant (lipophilic in nature) delivery system for cancer vaccines (Fig.…”

Section: Therapeutic Applications Of Nanobiotechnologymentioning

confidence: 99%

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Therapeutic applications of nanobiotechnology

et al. 2023

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Nanobiotechnology, as a novel and more specialized branch of science, has provided a number of nanostructures such as nanoparticles, by utilizing the methods, techniques, and protocols of other branches of science. Due to the unique features and physiobiological characteristics, these nanostructures or nanocarriers have provided vast methods and therapeutic techniques, against microbial infections and cancers and for tissue regeneration, tissue engineering, and immunotherapies, and for gene therapies, through drug delivery systems. However, reduced carrying capacity, abrupt and non-targeted delivery, and solubility of therapeutic agents, can affect the therapeutic applications of these biotechnological products. In this article, we explored and discussed the prominent nanobiotechnological methods and products such as nanocarriers, highlighted the features and challenges associated with these products, and attempted to conclude if available nanostructures offer any scope of improvement or enhancement. We aimed to identify and emphasize the nanobiotechnological methods and products, with greater prospect and capacity for therapeutic improvements and enhancements. We found that novel nanocarriers and nanostructures, such as nanocomposites, micelles, hydrogels, microneedles, and artificial cells, can address the associated challenges and inherited drawbacks, with help of conjugations, sustained and stimuli-responsive release, ligand binding, and targeted delivery. We recommend that nanobiotechnology, despite having few challenges and drawbacks, offers immense opportunities that can be harnessed in delivering quality therapeutics with precision and prediction. We also recommend that, by exploring the branched domains more rigorously, bottlenecks and obstacles can also be addressed and resolved in return. Graphical Abstract

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Section: Therapeutic Applications Of Nanobiotechnologymentioning

confidence: 99%

Section: Therapeutic Applications Of Nanobiotechnologymentioning

confidence: 99%

Therapeutic applications of nanobiotechnology

et al. 2023

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“…NMR spectroscopy (Bruker, Avance III 400 MHz) was used to determine the number of protons in the NC and various SCs. 1 H NMR analysis was performed by dissolving the samples in 2% CD 3 COOD and D 2 O solutions. To increase the solubility of SC, all of the samples were measured at 70 °C.…”

Section: H Nuclear Magneticmentioning

confidence: 99%

Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan

Marlina,

Misran

2023

ACS Omega

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Stearoyl chitosan (SC), derived from the acylation of chitosan, contributes to the efficiency of drug delivery systems because of its structure, which accommodates the drug in a particle. Nonetheless, its role in chemotherapy has been largely unexplored. The present study involves the synthesis of stearoyl chitosan through the reaction of depolymerized chitosan with stearoyl chloride under mild reaction conditions. The resulting compound was subjected to structural analysis utilizing Fourier-transform infrared (FTIR) spectroscopy, 1H NMR, and X-ray diffraction (XRD) spectroscopy. The dispersion of SC molecules in phosphate-buffered saline (PBS) forms SC nanoparticles. The best dispersion of SC in the solution was achieved at a 1:60 chitosan-to-stearoyl chloride weight ratio. Three antimetabolite drugs, methotrexate, pemetrexed, and raltitrexed, were selected to examine the loading efficacy of SC. Pemetrexed had the highest drug-loading value of 36.8% among the three antimetabolites incorporated into SC, along with an encapsulation efficiency of 85.1%. The size of SC loaded with antimetabolites ranged from 225 to 369 nm, and their spherical form was verified via a transmission electron microscope. The in vitro release study showed that SC demonstrated controlled drug release, suggesting that SC nanoparticles have significant promise as a delivery strategy for chemotherapy.

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“…[15][16][17] Moreover, nanoparticles with long systemic circulation tend to accumulate in tumor tissues, while the surface charge greatly affects the distribution and retention behavior of nanoparticles in vivo. [18][19][20] Negatively charged drug carrier particles are less prone to be cleared by mononuclear phagocyte system, since the cell membrane is negatively charged. 21,22 In addition, the combination of drugs with different mechanisms can synergistically enhance the antitumor therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

“Shell-Core” Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects

Zeng¹,

Sun²,

Fang³

et al. 2023

IJN

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Background Synergistic chemotherapy has been proved as an effective antitumor means in clinical practice. However, most co-administration treatment often lacks simultaneous control over the release of different chemotherapeutic agents. Materials and Methods β -cyclodextrin modified hyaluronic acid was the “shell”, and the oxidized ferrocene-stearyl alcohol micelles served as the “core”, where doxorubicin (DOX) and curcumin (CUR) were loaded in shell and core of the bilayer nanoparticles (BNs), respectively. The pH- and glutathione (GSH)-responsive synchronized release behavior was evaluated in different mediums, and the in vitro and in vivo synergistic antitumor effect and CD44-mediated tumor targeting efficiency were further investigated. Results These BNs had a spherical structure with the particle size of 299 ± 15.17 nm, while the synchronized release behaviour of those two drugs was proved in the medium with the pH value of 5.5 and 20 mM GSH. The co-delivery of DOX and CUR reduced the IC 50 value by 21% compared to DOX alone, with a further 54% reduction after these BNs delivery measurements. In tumor-bearing mouse models, these drug-loaded BNs showed significant tumor targeting, enhanced antitumor activity and reduced systemic toxicity. Conclusion The designed bilayer nanoparticle could be considered as potential chemotherapeutic co-delivery platform for efficient synchronized microenvironment respond and drug release. Furthermore, the simultaneous and synergistic drug release guaranteed the enhanced antitumor effects during the co-administration treatment.

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5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy

Cited by 66 publications

References 74 publications

Therapeutic applications of nanobiotechnology

Therapeutic applications of nanobiotechnology

Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan

“Shell-Core” Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects

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