5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment

Khallaf, Rasha A.; Salem, Heba F.; Abdelbary, Ahmed

doi:10.1080/10717544.2016.1194498

Cited by 86 publications

(29 citation statements)

References 33 publications

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“…The method we propose is a combination of 5-FU and SLNs. There are several literature reports suggesting a great potential of such a combination [19][20][21]. Use of SLNs has a lot of advantages because, for example, they can be loaded with both hydrophobic and hydrophilic compounds, and their preparation usually does not involve any toxic solutions [22].…”

Section: Discussionmentioning

confidence: 99%

Possibilities in the application of solid lipid nanoparticles in combination with 5-fluorouracil to overcome the drugresistance of non-small cell lung cancer cell line A549

Zielińska

Nawrocka

Rydzkowski

et al. 2018

Medical Research Journal

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Introduction: Multidrug resistance of non-small cell lung cancer cells is associated with a high percentage of therapeutic failures. The aim of this study was to assess the ability of solid lipid nanoparticles as a transporter of the conventionally used cytostatic (5-fluorouracil) to overcome the resistance of A549 cells. Material and methods: MTT assay was used to assess the differences in viability of cells treated with 5-fluorouracil alone or in combination with different types of solid lipid nanoparticles. Type of cell death and distribution of cell cycle phases were evaluated using flow cytometry. Results: The use of nanoparticles as a 5-fluorouracil transporter reduced the viability of A549 cells to a greater extent than the cytostatic alone. This was mainly due to the increase in apoptosis, but also necrosis and cell cycle arrest. Conclusion: Our results indicate the great potential of nanotechnology in the treatment of non-small cell lung cancer. By using nanoparticles, it is possible to sensitise tumour cells to cytostatics to which they are normally resistant. In addition, literature data confirm the safety of solid lipid nanoparticle application.

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Section: Discussionmentioning

confidence: 99%

Possibilities in the application of solid lipid nanoparticles in combination with 5-fluorouracil to overcome the drugresistance of non-small cell lung cancer cell line A549

Zielińska

Nawrocka

Rydzkowski

et al. 2018

Medical Research Journal

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“…SLN-treated mice exhibited reduced inflammatory reactions, with reduced degrees of keratosis. 25 Studies demonstrated that FA, or vitamin B9, played a vital role in mammalian cell growth. FA has a high binding affinity with the folic acid receptor (FAR), which is upregulated on the surface of many cancer cells, and limited distribution was found in normal tissues.…”

Section: -Fu Release From Au-npsmentioning

confidence: 99%

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Jahangirian¹,

Kalantari²,

Izadiyan³

et al. 2019

IJN

178

106

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Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Currently, many nanoparticles (NPs) are under investigation for drug delivery including those for cancer therapy. Targeted nanomaterials bind selectively to cancer cells and greatly affect them with only a minor effect on healthy cells. Gold nanoparticles (Au-NPs), specifically, have been identified as significant candidates for new cancer therapeutic modalities because of their biocompatibility, easy functionalization and fabrication, optical tunable characteristics, and chemophysical stability. In the last decade, there has been significant research on Au-NPs and their biomedical applications. Functionalized Au-NPs represent highly attractive and promising candidates for drug delivery, owing to their unique dimensions, tunable surface functionalities, and controllable drug release. Further, iron oxide NPs due to their "superparamagnetic" properties have been studied and have demonstrated successful employment in numerous applications. In targeted drug delivery systems, drug-loaded iron oxide NPs can accumulate at the tumor site with the aid of an external magnetic field. This can lead to incremental effectiveness in drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order for the application of iron oxide NPs in the human body to be realized, they should be biodegradable and biocompatible to minimize toxicity. This review illustrates recent advances in the field drug and small molecule delivery such as fluorouracil, folic acid, doxorubicin, paclitaxel, and daunorubicin, specifically when using gold and iron oxide NPs as carriers of anticancer therapeutic agents.

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“…Highly penetrating shell‐enriched SLNs loaded with 5‐FU were prepared using lecithin and poloxamer 188. The diffusion of 5‐FU SLN formulation was doubled when compared with the free drug …”

Section: Particulate Drug Delivery Systemsmentioning

confidence: 99%

“…Hafeez et al 24 compared dacarbazine suspension and nanoparticulate cream wherein NP cream presented higher rate of drug release and penetration in cancer cells owing to its nanostructure.Highly penetrating shell-enriched SLNs loaded with 5-FU were prepared using lecithin and poloxamer 188. The diffusion of 5-FU SLN formulation was doubled when compared with the free drug 25. Geetha et al proved the need for sesamol-loaded SLNs in skin cancer treatment since a significant flux across mouse skin upon topical application of sesamol was observed.…”

mentioning

confidence: 99%

Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview

Ravikumar

Tatke

2019

J of Cosmetic Dermatology

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Background The three forms of skin cancer are cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Melanoma skin cancer is an aggressive type and one of the most chemotherapy‐resistant malignancies. Conventional topical products are beset with limitations, leading to lower efficacy. There is a growing need to develop topical formulations encapsulated in polymeric and lipid nanoparticles, nanoemulsions, dendrimers, and liposomes exhibiting enhanced skin penetration and longer skin retention leading to better efficacy. Objective The objective of this article is the screening of reported novel drug encapsulated delivery systems effective topically in melanoma chemoprevention. Aim The scope of this work is to provide an overview pertaining to the development and evaluation of three exemplary drug delivery systems (DDS), namely vesicular, particulate, and specialized emulsions. Methods Topical drug delivery approaches targeting skin cancer have been reviewed and discussed. The focal point of the article is presentation of insights from published studies. Results This review focuses on the novel delivery systems in chemoprevention of melanoma with discussion highlighting on advances in topical delivery. Conclusion Literature indicates that drug‐loaded encapsulated topical formulations when compared with conventional dosage forms for skin cancer treatment exhibit greater efficacy and provide benefits like extended drug release, protection of the active ingredient against degradation, and lower skin irritation. Incorporation of phytoconstituents in newer delivery systems will be the way forward for improved topical chemoprevention strategy in melanoma. This has raised hope in making dermal therapy more useful and acceptable.

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5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment

Abstract: SLN possesses the capacity to be manipulated to entrap and release hydrophilic antitumor drugs with ease.

Cited by 86 publications

References 33 publications

Possibilities in the application of solid lipid nanoparticles in combination with 5-fluorouracil to overcome the drugresistance of non-small cell lung cancer cell line A549

Possibilities in the application of solid lipid nanoparticles in combination with 5-fluorouracil to overcome the drugresistance of non-small cell lung cancer cell line A549

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview

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