2024
DOI: 10.1002/jex2.70010
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5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles

Shimian Qu,
Hannah M. Nelson,
Xiao Liu
et al.

Abstract: Abstract5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair. However, 5‐FU is also incorporated into RNA causing defects in RNA metabolism, inhibition of pseudouridine modification, and altered ribosome function. We examined the impact of 5‐FU on post‐transcriptional small RNA modifications (PTxMs) and the expression and export … Show more

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