5-Fluorouracil vs avastin as adjunct to conjunctival autograft in the surgical treatment of pterygium

Bekibele, CO; Sarimiye, Tarela; Ogundipe, Ayobade O.; Olaniyan, Segun Isaac

doi:10.1038/eye.2016.29

Cited by 16 publications

(15 citation statements)

References 21 publications

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“…Some studies [7,[17][18][19][20][21][22][23][24][25] have involved the application of bevacizumab and ranibizumab in the prevention of pterygium recurrence; however, the method, time, frequency, and dosing were not uniform.…”

Section: Discussionmentioning

confidence: 99%

“…Alsmman et al [20] recognised that there was a decrease in pterygium epithelial cells, degeneration and apoptosis of stromal fibres, deformation and degradation of glial and elastic fibres, and destruction of capillaries in patients who accepted subconjunctival injection of bevacizumab before pterygium excision (1 month). Bekibele et al [7] showed that there was no significant difference in the success and recurrence rates between the subconjunctival injections of bevacizumab and 5-Fu during autologous conjunctival transplantation. Nuzzi et al [21] found that there was a significantly lower recurrent rate after 6 months of subconjunctival bevacizumab injections on pre-and post-operative primary pterygium excision than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Sample size was calculated from proportions with assumption of success rate of about 80% for 5-Fu and conbercept with surgeries, including simple excision or conjunctiva autograft surgery, alpha error, 0.05% and a power of 90%, N ¼ Za=P0ð1ÀP0ÞÀZb=P1ð1ÀP1Þ 2 P1ÀP0 ¼70 [7]. Moreover, combining with our team's capability of taking pterygium patients, the size was estimated as 96.…”

Section: Methodsmentioning

confidence: 99%

“…Dosing was as follows. Dosing was not uniform for anti-VEGF drugs, most of which were in the range of 0.5-2.5 mg [7,20,21]. Anti-VEGF drugs were shown to be safe for humans in this dose range.…”

Section: Tablementioning

confidence: 99%

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Effect of multiple subconjunctival conbercept injections as an adjuvant to the surgical treatment of pterygium: a prospective randomised comparative 6-month follow-up study

Zhang

Tian

Zheng

et al. 2019

Eye

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Objective To evaluate the safety and efficacy of multiple subconjunctival injections of conbercept for pterygium patients after surgery. Methods As a prospective randomised interventional trial, 96 eyes from 96 patients with a tendency to recur were collected and divided randomly into conbercept and 5-fluorouracil groups on the 5th day after pterygium. All patients received three subconjunctival injections of conbercept (0.2 ml) or 5-fluorouracil (0.2 ml) on the 5th day (baseline), and 2 and 4 weeks postoperatively. The pterygium morphology, colour intensity, recurrence, and complications were recorded and analysed pre-1st injection and 1 day, 1 week, 1 month, 3 months, and 6 months post-3rd injection. Moreover, no patient was drop-out. Results There were striking differences between the two groups on post-3rd injections 1 day, 1 week, 1 month, 3 months, and 6 months (p = 0.001, 0.002, 0.000, 0.000, and 0.002, respectively) with respect to colour intensity: the eyes in conbercept group were lighter than the 5-Fu group. On post-3rd injection 6 months, prominent disparities existed between the two groups with respect to pterygium morphology (p = 0.006) and recurrence (p = 0.002), occurred in the conbercept group prior to the 5-Fu group. Moreover, corneal abrasions were not noted in the conbercept group, which was significantly less than the 5-Fu group (17/48; p = 0.000). There was no conspicuous discrepancy between the two groups with respect to subconjunctival haemorrhage (p = 0.789) and persistent epithelial defects (p = 0.078). Conclusion Multiple subconjunctival conbercept injections as an adjunct therapy for pterygium surgery was shown to be safe, effective, and well-tolerated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

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Effect of multiple subconjunctival conbercept injections as an adjuvant to the surgical treatment of pterygium: a prospective randomised comparative 6-month follow-up study

Zhang

Tian

Zheng

et al. 2019

Eye

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“…While the rst report on the toxicity of chloroquine was published in 1959, the rst such report about hydroxychloroquine toxicity was published 1967 (2,3). In recent years, hydroxychloroquine has been used widely because of the lesser toxic effects (4).…”

Section: Introductionmentioning

confidence: 99%

The Assessment of Structural and Functional Test Results for Early Detection of Hydroxychloroquine Macular Toxicity

Sonalcan¹,

Aksoy

Gündoğdu

et al. 2021

Preprint

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PurposeTo assess structural (optical coherence tomography, fundus autofluorescence) and functional (contrast sensitivity and visual field) test results used for detecting early retinal changes in patients who were using oral hydroxychloroquine.METHODSPatients who were taking oral hydroxychloroquine for at least one year were divided into two groups in accordance with the duration of drug use. Group 1 and 2 comprised patients with drug use exceeding 5 years and 1–5 years, respectively. Besides, drug-free control group was composed. Upon full ophthalmic examination, the mean retinal nerve layer thickness (RNFL), central macular thickness (CMT), ganglion cell-inner plexiform layer thickness (GC-IPL), static 10 − 2 visual field, fundus autofluorescence (FAF) imaging, and contrast sensitivity tests were performed and statistically compared between groups.RESULTSRNFL thickness was found to be statistically significantly lower in the median and temporal quadrant than in the control group. No significant difference was found between the groups in the other quadrants. The GC-IPL sectoral and mean thickness were found to be statistically lower in all quadrants as compared to the control group in the patient groups. CMT was also found to be similar in all three groups. There was no significant difference between the groups in visual field parameters. While macular FAF images were significantly higher in the drug users than in the control group, no significant difference was found between the three groups in foveal FAF images. Contrast sensitivity measurements were significantly lower in the patient groups than in the control group at all spatial frequencies except 6 and 18 cycles / degree.CONCLUSIONSThe combined use of structural and functional tests in patients using hydroxychloroquine provides useful information in detecting early retinal changes.

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Comparison of postoperative topical interferon-α2b versus intraoperative mitomycin C for pterygium recurrence prevention: a randomized clinical trial

Akbari,

Moghadam,

Leili

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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5-Fluorouracil vs avastin as adjunct to conjunctival autograft in the surgical treatment of pterygium

Cited by 16 publications

References 21 publications

Effect of multiple subconjunctival conbercept injections as an adjuvant to the surgical treatment of pterygium: a prospective randomised comparative 6-month follow-up study

Effect of multiple subconjunctival conbercept injections as an adjuvant to the surgical treatment of pterygium: a prospective randomised comparative 6-month follow-up study

The Assessment of Structural and Functional Test Results for Early Detection of Hydroxychloroquine Macular Toxicity

Comparison of postoperative topical interferon-α2b versus intraoperative mitomycin C for pterygium recurrence prevention: a randomized clinical trial

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