5-HT excites globus pallidus neurons by multiple receptor mechanisms

Chen, L.; Yung, Kin Lam; Chan, Ying-Shing; Yung, Wing-Ho

doi:10.1016/j.neuroscience.2007.11.003

Cited by 44 publications

(31 citation statements)

References 65 publications

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“…In contrast, Querejeta et al (2005) found that local application of a 5-HT receptor agonist, or fluoxetine, excites most of the GPe neurons in anaesthetized rats, showing the presence of a serotonergic excitatory tone on GP neurons. This evidence was further confirmed by a recent patch-clamp recording study (Chen et al, 2008). In reality, the effect of 5-HT is more complex because of the existence of various receptor subtypes on presynaptic and postsynaptic membranes in the pallidum.…”

Section: -Ht Modulation Of Gp Activitysupporting

confidence: 65%

“…The application of 5-HT into the superfusion medium of brain slices containing GP neurons directly stimulated the receptors of the recorded neurons and produced a reversible depolarization of their membrane that consequently increased the firing rate of these neurons (Chen et al, 2008). 5-HT postsynaptic excitation of pallidal neurons occurs through activation of 5-HT 4 or 5-HT 7 receptors but not via 5-HT 2C and 5-HT 3 receptors (Bengtson et al, 2004;Kita et al, 2007;Chen et al, 2008;Hashimoto and Kita, 2008).…”

Section: -Ht Modulation Of Gp Activitymentioning

confidence: 96%

“…5-HT postsynaptic excitation of pallidal neurons occurs through activation of 5-HT 4 or 5-HT 7 receptors but not via 5-HT 2C and 5-HT 3 receptors (Bengtson et al, 2004;Kita et al, 2007;Chen et al, 2008;Hashimoto and Kita, 2008).…”

Section: -Ht Modulation Of Gp Activitymentioning

confidence: 98%

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Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

Matteo

Pierucci

Esposito

et al. 2008

Progress in Brain Research

138

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Several recent studies have emphasized a crucial role for the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia. These observations are supported by anatomical evidence demonstrating large serotonergic innervation of all the basal ganglia nuclei. In fact, serotonergic terminals have been reported to make synaptic contacts with both substantia nigra dopamine-containing neurons and their terminal areas such as the striatum, the globus pallidus and the subthalamus. These brain areas contain a high concentration of serotonin (5-HT), with the substantia nigra pars reticulata receiving the greatest input. In this chapter, the distribution of different 5-HT receptor subtypes in the basal ganglia nuclei will be described. Furthermore, evidence demonstrating the serotonergic control of basal ganglia activity will be reviewed and the contribution of the different 5-HT receptor subtypes examined. The new avenues that the increasing knowledge of 5-HT in motor control has opened for exploring the pathophysiology and pharmacology of Parkinson's disease and other movement disorders will be discussed. It is clear that these avenues will be fruitful, despite the disappointing results so far obtained by clinical studies with selective 5-HT ligands. Nevertheless, these studies have led to a great increase in the attention given to the neurotransmitters of the basal ganglia and their connections.

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Section: -Ht Modulation Of Gp Activitysupporting

confidence: 65%

Section: -Ht Modulation Of Gp Activitymentioning

confidence: 96%

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Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

Matteo

Pierucci

Esposito

et al. 2008

Progress in Brain Research

138

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“…The activity of GP neurons is controlled by three major sources: striatal GABAergic inhibitory inputs, subthalamic glutamatergic excitatory inputs, and BG intrinsic collateral inhibitory inputs (Hazrati and Parent, 1992;Parent et al, 2000;Nambu et al, 2000). Furthermore, GP also receives external excitatory projections, such as cortical inputs from frontal cortex, thalamo-pallidal fibers arising from neurons located in the parafascicular nucleus, serotoninergic innervation from the dorsal raphe nucleus, and cholinergic/GABAergic/glutamatergic projection from the pedunculopontine tegmentum (Parent and Hazrati, 1995;Naito and Kita, 1994;Mouroux et al, 1997;Yasukawa et al, 2004;Chen et al, 2008). In turn, GABAergic GP neurons project to the striatum, the subthalamic nucleus (STN), both the substantia nigra pars compacta (SNpc) and pars reticulata (SNpr) and the entopeduncular nucleus, homologous to the internal segment of the GP in primates Lee and Tepper, 2009).…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide-active compounds modulate the intensity of glutamate-evoked responses in the globus pallidus of the rat

et al. 2011

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Aim: The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. Main methods: Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG), a NO donor, and Nω-nitro-Larginine methyl ester (L-NAME), a NOS inhibitor. Key findings: Most GP cells were excited by SNOG whereas administration of L-NAME induced decrease of GP neurons activity. Nearly all neurons responding to SNOG and/or L-NAME showed significant modulation of their excitatory responses to the administration of iontophoretic GLU. In these cells, the changes induced by NO-active drugs in the magnitude of GLU-evoked responses were used as indicators of NO modulation. In fact, when a NO-active drug was co-iontophoresed with GLU, significant changes in GLU-induced responses were observed: generally, increased magnitudes of GLU-evoked responses were observed during SNOG ejection, whereas the administration of L-NAME decreased responses to GLU. Significance: The results suggest that the NO-active drugs modulate the response of GP neurons to glutamatergic transmission. Nitrergic modulation of glutamatergic transmission could play an important role in the control of GP bioelectric activity, considered a fundamental key in the BG function.

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“…It has been suggested that the activation of 5-HT 7 receptors modulates the function of GABAergic interneurons in the raphe nuclei [80]. The activation of 5-HT 7 receptors enhances the excitability of GABAergic neurons in globus pallidus [18] but 5-HT 7 receptors decrease GABA-dependent currents in the SCN [43]. Therefore, we examined the effect of the activation of 5-HT 7 receptors on GABAergic, spontaneous postsynaptic inhibitory currents (sIPSCs) recorded from CA1 pyramidal neurons.…”

Section: The Effects Of 5-ht 7 Receptor Activation On Hippocampal Excmentioning

confidence: 99%

Stress- and antidepressant treatment-induced modifications of 5-HT7 receptor functions in the rat brain

Tokarski

Bobula

Grzegorzewska-Hiczwa

et al. 2012

Pharmacological Reports

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Abstract:This paper summarizes a series of electrophysiological studies aimed at finding the effects of the activation of 5-HT 7 receptors on neuronal excitability as well as on excitatory and inhibitory synaptic transmission in the hippocampus and in the frontal cortex of the rat. These studies demonstrated that 5-HT 7 receptors play an important role in the modulation of the activity of the hippocampal network by regulating the excitability of pyramidal cells of the CA1 area, as well as via their effect on GABA and glutamatergic transmission. The reactivity of 5-HT 7 receptors in the hippocampus is decreased by repeated administration of antidepressant drugs and increased by a prolonged high level of corticosterone. More importantly, administration of antidepressant drug, imipramine, prevents the occurrence of corticosterone-induced changes in the function of hippocampal 5-HT 7 receptors. It has also been found that the blockade of 5-HT 7 receptors by the selective antagonist SB 269970, lasting for a few days, causes similar changes to those observed after long-term administration of antidepressants. Thus, it seems that the pharmacological blockade of 5-HT 7 receptors produces faster effects compared to classic antidepressant drugs. A similarity between the changes in the glutamatergic transmission induced by the blockade of 5 HT 7 receptors and those caused by repeated administration of the antidepressant drug, imipramine, has also been found in the frontal cortex. It has also been shown that the changes in glutamatergic transmission and the impairment of long-term synaptic plasticity in the frontal cortex of animals subjected to repeated restraint stress are reversed by the blockade of 5-HT 7 receptors. Overall, these studies, together with the data provided by other investigators, support the hypothesis that 5-HT 7 receptor antagonists may become a prototype of a new class of antidepressant drugs. Such compounds will not function by blocking 5-HT reuptake, as many of the currently used drugs, but through a direct interaction with the 5-HT 7 receptor. This type of action is highly selective and usually does not require the occurrence of adaptive changes in neuronal functions, thus allowing for a much quicker therapeutic effect.

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5-HT excites globus pallidus neurons by multiple receptor mechanisms

Cited by 44 publications

References 65 publications

Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

Nitric oxide-active compounds modulate the intensity of glutamate-evoked responses in the globus pallidus of the rat

Stress- and antidepressant treatment-induced modifications of 5-HT7 receptor functions in the rat brain

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