5-HT is associated with the dysfunction of regulating T cells in patients with allergic rhinitis

Yang, Gui; Wu, Guangyao; Yao, Wenkai; Guan, Li; Geng, Xinyu; Liu, Jiang‐Qi; Liu, Zhiqiang; Yang, Liteng; Huang, Qinmiao; Zeng, Xianhai; Yang, Pingchang

doi:10.1016/j.clim.2022.109101

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Regulating T lymphocytes (Treg) contributes to the acquisition of allergy tolerance [ 41 ]. Tryptamine (TRP) and 5-Hydroxymethyltryptamin (5-HT) can interact with immune cells, triggering the conversion of Tregs to Th17 cells [ 42 ]. As shown in Figure 3 C,D, both the levels of TRP and 5-HT were significantly higher in the BP group than that in the CK, 2E-BP and 3E-BP groups, suggesting that 2E-BP and 3E-BP could alleviate allergic reactions in mice.…”

Section: Resultsmentioning

confidence: 99%

Allergenicity Alleviation of Bee Pollen by Enzymatic Hydrolysis: Regulation in Mice Allergic Mediators, Metabolism, and Gut Microbiota

Tao

Zhou

et al. 2022

Foods

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Bee pollen as a nutrient-rich functional food has been considered for use as an adjuvant for chronic disease therapy. However, bee pollen can trigger food-borne allergies, causing a great concern to food safety. Our previous study demonstrated that the combined use of cellulase, pectinase and papain can hydrolyze allergens into peptides and amino acids, resulting in reduced allergenicity of bee pollen based on in vitro assays. Herein, we aimed to further explore the mechanisms behind allergenicity alleviation of enzyme-treated bee pollen through a BALB/c mouse model. Results showed that the enzyme-treated bee pollen could mitigate mice scratching frequency, ameliorate histopathological injury, decrease serum IgE level, and regulate bioamine production. Moreover, enzyme-treated bee pollen can modulate metabolic pathways and gut microbiota composition in mice, further supporting the alleviatory allergenicity of enzyme-treated bee pollen. The findings could provide a foundation for further development and utilization of hypoallergenic bee pollen products.

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Section: Resultsmentioning

confidence: 99%

Allergenicity Alleviation of Bee Pollen by Enzymatic Hydrolysis: Regulation in Mice Allergic Mediators, Metabolism, and Gut Microbiota

Tao

Zhou

et al. 2022

Foods

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“…The development of AR also correlates with the number of Th17 cells ( 33 ). Additionally, a correlation has been reported between the expression of IL-17 and IL-17RB and the severity of AR symptoms ( 34 – 36 ).…”

Section: Effects Of T Cells On Nasal Mucosamentioning

confidence: 99%

Recent advances in understanding the effects of T lymphocytes on mucosal barrier function in allergic rhinitis

Yang,

Sun,

Zhu

et al. 2023

Front. Immunol.

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Allergic rhinitis is a non-infectious chronic inflammatory disease of the nasal mucosa that affects T cells and their cytokines. T cells play significant roles in the development of allergic inflammatory diseases by orchestrating mechanisms underlying innate and adaptive immunity. Although many studies on allergic rhinitis have focused on helper T cells, molecular makeup, and pathogenesis-related transduction pathways, pathological mechanisms have not yet been completely explored. Recent studies have suggested that T cell status may play an important role in the interaction between T cells and the nasal mucosal barrier in allergic rhinitis. This study aimed to explore the interactions between T cells and nasal mucosal barriers in allergic rhinitis and to review the therapeutic modalities of pertinent biological agents involving T cells.

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5-HT induces regulatory B cells in fighting against inflammation-driven ulcerative colitis

Wan,

Ma,

Han

et al. 2023

International Immunopharmacology

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5-HT is associated with the dysfunction of regulating T cells in patients with allergic rhinitis

Cited by 6 publications

References 26 publications

Allergenicity Alleviation of Bee Pollen by Enzymatic Hydrolysis: Regulation in Mice Allergic Mediators, Metabolism, and Gut Microbiota

Allergenicity Alleviation of Bee Pollen by Enzymatic Hydrolysis: Regulation in Mice Allergic Mediators, Metabolism, and Gut Microbiota

Recent advances in understanding the effects of T lymphocytes on mucosal barrier function in allergic rhinitis

5-HT induces regulatory B cells in fighting against inflammation-driven ulcerative colitis

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