“…In this context, members of the Rho family of small GTPases, whose most prominent feature is the regulation of the actin cytoskeleton (Hall, 1994;Machesky and Hall, 1997;Norman et al, 1994) represent key players that are crucially involved in the regulation of dendritic cell migratory properties (Benvenuti et al, 2004;Harada et al, 2012;Lammermann et al, 2009;Ocana-Morgner et al, 2011). Our previous data have indicated that, in neurons, actin cytoskeleton rearrangements can be regulated by 5-HT 7 R through the G 12 protein-mediated activation of the small GTPase Cdc42 (Kobe et al, 2012;Kvachnina et al, 2005;Nobes and Hall, 1995a,b). We have also demonstrated a high basal activity of 5-HT 7 R towards Cdc42 signaling in neuronal cells (Kvachnina et al, 2005), suggesting that both basal activity and agonist-mediated stimulation of the 5-HT 7 R-Cdc42 signaling pathway might contribute to morphological rearrangements of cells.…”