5.HT1 receptors in the vertebrate brain

Waeber, Christian; Mm, Dietl; Hoyer, Daniel; Palacios, J. M.

doi:10.1007/bf00260602

Cited by 86 publications

(6 citation statements)

References 28 publications

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“…Values forebrain regions also express RB-10 InRNA, especially the program, were KDI CAI pyramidal neurons. This, together with results from receptor autoradiographic studies showing high levels of 5-HTlB receptor binding in subiculum but very low levels in CAI (Pazos and Palacios, 1985;Waeber et al, 1989;Radja et al, 1991), suggest that these receptors are located on CAl efferents in the subiculum, and not on pyramidal cell dendrites or somas within the CAl. Projections from cells within the caudate-putamen and raphe nuclei could also account for the contrasting dense 5-HTIB receptor binding and undetectable mRNA levels within the globus pallidus and substantia nigra.…”

Section: Values Whichmentioning

confidence: 88%

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

et al. 1991

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To date, there have been at least eight different receptors for the neurotransmitter serotonin (5‐HT) identified in the central nervous system. These receptors fall into four pharmacological classes: 5‐HT1, 5‐HT2, 5‐HT3 and 5‐HT4. The 5‐HT1 class has been shown to contain at least four pharmacologically distinct subtypes, 5‐HT1A‐D. Of these, cDNAs encoding the 5‐HT1A and 5‐HT1C receptors have been previously characterized. We now report the cloning and expression of a rat brain cDNA encoding another member of the 5‐HT1 receptor family. Transient expression of this clone demonstrated high‐affinity binding of [3H]5‐HT with a pharmacological profile corresponding to that of the 5‐HT1B subtype: 5‐CT, 5‐HT greater than propranolol greater than methysergide greater than rauwolscine greater than 8‐OH‐DPAT. In situ hybridization revealed expression of cognate mRNA within cells of the dorsal and median raphe nuclei, consistent with previous reports that the 5‐HT1B receptor acts as an autoreceptor on 5‐HT terminals in this species. mRNA expression was also detected in cells within the CA1 region of hippocampus, striatum, layer 4 of cortex and in the cerebellum, suggesting a previously unrecognized post‐synaptic role for the 5‐HT1B receptor.

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Section: Values Whichmentioning

confidence: 88%

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

et al. 1991

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“…Although the 5‐HT 1B receptor is found in rat, mouse, hamster and opossum but is absent in all other mammalian species, the 5‐HT 1Dß receptor is absent in rodents but detected in dog, guinea pig and humans 44,45 . The distribution of 5‐HT 1B and 5‐HT 1Dß receptors is similar across species, and it has therefore been postulated, and confirmed by molecular cloning studies, that 5‐HT 1B receptors are the rodent homologues of the human 5‐HT 1Dß receptors 44,46 . A single amino acid is responsible for the pharmacological difference between these two receptors 47 .…”

Section: Impulsivity Is a Ubiquitous Processmentioning

confidence: 99%

Insights into the Neurobiology of Impulsive Behavior from Serotonin Receptor Knockout Mice

Brunner

Hen

1997

Annals of the New York Academy of Sciences

216

131

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Although the concept of impulsivity has proved useful in human and animal studies of addiction, violent aggression, and violent suicide, and has been recognized as an important component of human behavior, little research has been done to understand the underlying psychobiological mechanisms. We explore the concept of impulsivity and its relation with the neurotransmitter serotonin in the context of aggressive behavior and behavior associated with positive reinforcement using a knockout mouse that lacks one of the serotonin receptors, the 5-HT1B receptor. This knockout mouse shows more impulsive aggression, acquires cocaine self-administration faster, and drinks more alcohol than the corresponding wild-type control. We show that the impulsive characteristics of these mice are not due to change in cognitive functions: in a cognitive task involving a choice between a small immediate one and a larger more delayed reward, knockout mice showed intact choice and timing capabilities and good discrimination of reward amounts. Thus, this mouse may prove an animal model of addiction and motor impulsivity.

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“…Four of the 5-HT, receptor subtypes have been cloned ,,,,,,) and extensive studies on the pharmacology, biochemistry and behavioral effects governed by these receptors suggest that they mediate different functions and are likely to be involved in different pathophysiological conditions Hartig et al, 1990;Middlemiss and Tricklebank, 19921. The S-HT,, receptor appears to be confined to rat, mouse, and opossum, whereas the 5-HT,, receptor has been demonstrated in human, pig, dog, guinea pig, calf, and pigeon [Heuring and Peroutka, 1987;Waeber et al, 1988;19891. The pharmacology, second messenger system, and regional neuroanatomical distribution of the 5-HT,, and 5-HTID receptor subtypes have suggested that they might be species homologues of the same receptor subtype.…”

Section: Introductionmentioning

confidence: 97%

Studies on the effects of 5‐HT_1A drugs in the pigeon

Barrett

1992

Drug Development Research

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A number of compounds with high receptor binding affinity for the 5-hydroxytryptamine (5-HT) receptor subtype designated as 5-HT,, can produce anxiolytic and/or antidepressant effects in humans. In contrast to the traditional benzodiazepine anxiolytics, many of the clinically efficacious 5-HTl, drugs are either ineffective or produce inconsistent results in traditional preclinical anxiolytic screens using behavioral procedures with rodents. In preclinical antidepressant models with these animals, however, effects of the 5-HT1, drugs, as well as those of traditional antidepressant compounds, are predictive of their antidepressant activity in humans. In contrast, 5-HTl, drugs are quite effective in pigeons studied under a rather conventional punishment or conflict-type procedure that is also sensitive to the benzodiazepine anxiolytics. However, traditional antidepressant compounds, such as the tricyclic drugs amitriptyline and irnipramine, as well as the 5-HT reuptake blockers such as fluoxetine, do not show effects similar to the newer 5-HTl, drugs in this procedure. Thus, in rodents, current antidepressant models are sensitive to drugs that appear to function through different mechanisms, whereas conflict-type procedures typically do not reveal anxiolytic-like effects with 5-HT,, drugs. The pigeon conflict procedure, however, discriminates between the 5-HTl A antidepressants and antidepressant drugs functioning through other systems, whereas the effects of known anxiolytics in this procedure are quite similar.Increases in punished responding with 5-HT1, drugs correlates highly (r= +0.83) with affinity for the 5-HTl, receptor in pigeons. This paper reviews behavioral studies conducted with the pigeon in which the focus has been on the analysis of 5-HTl , compounds and addresses additional work that is required to answer many of the outstanding questions about this new class of anxiolytic and/or antidepressant drugs. o

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5.HT1 receptors in the vertebrate brain

Cited by 86 publications

References 28 publications

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

Insights into the Neurobiology of Impulsive Behavior from Serotonin Receptor Knockout Mice

Studies on the effects of 5‐HT_1A drugs in the pigeon

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5.HT1 receptors in the vertebrate brain

Cited by 86 publications

References 28 publications

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

Insights into the Neurobiology of Impulsive Behavior from Serotonin Receptor Knockout Mice

Studies on the effects of 5‐HT1A drugs in the pigeon

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Studies on the effects of 5‐HT_1A drugs in the pigeon