5-HT3 Receptor Antagonists for Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials

Wang, Wen; Zhou, Liang; Wu, Lingling; Wang, Tong; Zhang, Chao-Bing; Sun, Li

doi:10.1007/s40261-016-0375-1

Cited by 19 publications

(15 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Micro to macro (M2M) as an advanced procedure for destabilizing the propofol microemulsions straightly before intravenous delivery of it has been developed properly. Through this novel procedure more stability could be achieved and simultaneously the injection pain would reduce potentially [45].…”

Section: Derivatives and Modification Of Propofol Agentsmentioning

confidence: 99%

A Review on Novel Progressions in Intravenous (IV) agents for Anesthesia

Zoroufchi

Abdollahpour

2019

JPRI

View full text Add to dashboard Cite

One of the main medical proficiencies involved with the procedure of patient’s perioperative care before, during and after operation is anesthesiology. This field of science has made a lot of hopeful progression in detection of new, secure, impressive, and productive procedures for proper management of patients. The most effective sedative–hypnotic agents which categorized in titratable intravenous medication, have highest medicinal effect and the least side effects. Currently a high effort is employed for developing such drugs with central focus on improving the available drugs structures for modifying their pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Various drugs are investigating for achieving more progression which includes etomidate, midazolam analogues, and diprivan. One of the main approaches for investigating about the development of anesthesia agents is swift screening of related libraries of molecular structure which evaluate phenotypic or structural assays of anesthetic and receptor interactions of agents. Due to the recently high demands of clinical operations for more sufficient anesthesia agents, the progression of anesthetic agents is experiencing a new generation of advanced clinical trials. In this regard, the current study is trying to provide a brief look on the newest anesthetic drugs and novel developed procedures which simplify this objective. This comprehensive study reviews would clarify the novel technology of progression of drugs which do not have physical addiction effects, distinctive system of anesthetic drug delivery, and the novel failures of drugs and their facilities.

show abstract

Section: Derivatives and Modification Of Propofol Agentsmentioning

confidence: 99%

A Review on Novel Progressions in Intravenous (IV) agents for Anesthesia

Zoroufchi

Abdollahpour

2019

JPRI

View full text Add to dashboard Cite

show abstract

“…The exact mechanism of pain on injection is not known. Factors that appear to influence the incidence and the severity of pain include menstrual cycle, temperature, injection rate, infusion equipment, concentration of propofol, patient age, venous occlusion, and pretreatment medications 34 .…”

Section: New Innovations In Drug Developmentmentioning

confidence: 99%

Recent advances in intravenous anesthesia and anesthetics

Mahmoud

Mason

2018

F1000Res

View full text Add to dashboard Cite

show abstract

“…3 Several interventions have been advocated to alleviate the pain associated with propofol injection, which include addition of lignocaine, ketamine, 4 acetaminophen, 5 tramadol, 6 different doses of lidocaine, 7 and different concentrations of propofol 8 and topical nitroglycerin. 9 Other studies have suggested other methods for controlling pain, including the injection of low doses of narcotics such as sufentanil and butorphanol 10,11 injection in large vessels and lignocaine injection together with tourniquet closure, 12 cold or warm propofol, 13 metoclopramide injection as a premedication, 14 magnesium, 15 beta blocker, 16 midazolam, 17 5-HT3 receptor antagonists, 18 or Alpha-2 agonists like dexmedetomidine. 19…”

Section: Introductionmentioning

confidence: 99%

Management of Pain During Propofol Injection Using Intravenous Nitroglycerine

Hossain¹,

Rashid²,

Babu³

et al. 2020

KYAMC j.

View full text Add to dashboard Cite

Background: Propofol is an intravenous (IV) anesthetic agent, can irritate the skin, mucous membrane and venous intima. The main drawback is the pain at injection site following its intravenous injection. Objectives: This study was performed to evaluate the effect of intravenous nitroglycerine on pain in patients following propofol injection. Materials and Methods: Eighty adult patients of both sexes, aged 20-50 years, according to American Society of Anesthesiologists (ASA) physical status were divided into two equal groups (n=40) to receive 200 mcg intravenous nitroglycerine diluted in 10 ml saline (group A) and 10 ml normal saline as placebo (group B) at an ambient operating room temperature in a randomized and double blinded fashion to compare the pain-relieving effects of the drugs during propofol injection before the patients lost consciousness. The pain on propofol injection was assessed according to the Mc Crirrick and Hunter scale. Results: The overall incidence and severity of pain were significantly less in Groups A (nitroglycerine group) than group B (placebo group) (p< 0.05). The incidence of mild and moderate pain in Group A versus group B was 25% vs 45% and 15% vs 30% respectively (p<0.05). The incidence of score '0' (no pain) was higher in Group A (60%) than Group B (25%) (p<0.05). Conclusion: Pretreatment with 200 mcg nitroglycerine with venous occlusion for one minute is effective pretreatment in alleviating propofol injection pain when compared to placebo. KYAMC Journal Vol. 10, No.-4, January 2020, Page 202-205

show abstract

5-HT3 Receptor Antagonists for Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials

Cited by 19 publications

References 46 publications

A Review on Novel Progressions in Intravenous (IV) agents for Anesthesia

A Review on Novel Progressions in Intravenous (IV) agents for Anesthesia

Recent advances in intravenous anesthesia and anesthetics

Management of Pain During Propofol Injection Using Intravenous Nitroglycerine

Contact Info

Product

Resources

About