5-hydroxymethylfurfural-embedded poly (vinyl alcohol)/sodium alginate hybrid hydrogels accelerate wound healing

Kong, Fanting; Fan, Conghui; Yang, Yuhang; Lee, Bae Hoon; Wei, Kun

doi:10.1016/j.ijbiomac.2019.07.152

Cited by 65 publications

(43 citation statements)

References 38 publications

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“…5-HMF is an organic compound generated by sugar reduction through the Maillard reaction [11][12][13]; therefore, it is normally present in heat-processed foods such as honey, dried fruits, and fruit juices [14][15][16]. The anti-inflammatory and anti-allergic effects of 5-HMF have been reported in several recent studies [17][18][19][20][21]. For example, it has been reported that Lycium chinense, commonly called wolfberry, contains large amount of 5-HMF and that the fruit extract inhibits degranulation of rat basophilic leukemia (RBL) cells [17].…”

Section: Discussionmentioning

confidence: 99%

Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation

Uchida

Kato

Hattori

et al. 2020

IJMS

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Jabara (Citrus jabara Hort. ex Y. Tanaka) is a type of citrus fruit known for its beneficial effect against seasonal allergies. Jabara is rich in the antioxidant narirutin whose anti-allergy effect has been demonstrated. One of the disadvantages in consuming Jabara is its bitter flavor. Therefore, we fermented the fruit to reduce the bitterness and make Jabara easy to consume. Here, we examined whether fermentation alters the anti-allergic property of Jabara. Suppression of degranulation and cytokine production was observed in mast cells treated with fermented Jabara and the effect was dependent on the length of fermentation. We also showed that 5-hydroxymethylfurfural (5-HMF) increases as fermentation progresses and was identified as an active component of fermented Jabara, which inhibited mast cell degranulation. Mast cells treated with 5-HMF also exhibited reduced degranulation and cytokine production. In addition, we showed that the expression levels of phospho-PLCγ1 and phospho-ERK1/2 were markedly reduced upon FcεRI stimulation. These results indicate that 5-HMF is one of the active components of fermented Jabara that is involved in the inhibition of mast cell activation.

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Section: Discussionmentioning

confidence: 99%

Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation

Uchida

Kato

Hattori

et al. 2020

IJMS

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“…In the case of Konget alin vitro study, 5-HMF was found to effectively promote human skin fibroblast (HSF) proliferation and migration, and collagen production. In addition, 5-HMF-embedded PVA / SA hybrid hydrogels supported controlled release and good cell compatibility, and more importantly, enhanced in vivo wound healing through reduced inflammation, increased angiogenesis / vascularization, Increased production of collagen, and facilitated re-epithelialization 14 . Due to its excellent moisture retention property hydrogels played a significant role in skin tissue regeneration.…”

Section: Silk Fibroinmentioning

confidence: 97%

Current Review on Polymeric Hydrogel Based

Kiruba¹,

Arjun²,

Rajan³

2021

Int J Life Sci Pharm Res

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Skin tissue defects have become one of the major sources of mortality and morbidity among all age group people worldwide. Skin tissue engineering has enticed considerable heedfulness from researchers as an optimistic approach for repairing partial/ full thickness burn tissue. Skin is a highly vascularized, bio mineralized composite material composed of fibroblasts and collagen surrounded by specialized extracellular matrix with high mechanical strength and structural complexity. Although the auto grafts and allografts were regarded as the high attainment for wound repair, the approach was limited due to their inability revascularize and mimicking the damaged tissue. Further, the Polymeric hydrogels are very attractive skin tissue engineering scaffolds. The structural similarity of the polymeric hydrogels to the skin extracellular matrix provides additional benefits for non-invasive tissue repair. Owing to their poor healing ability, tissue regeneration was found to be challenging in skin tissue defects. However due to its excellent moisture retaining capabilities, biocompatibility and biodegradability several researchers shown considerable interest in potential applications of the hydrogels for skin tissue repair.Furthermore, recent progress involves the development of hydrogels with ideal mechanical and fast stimulus responsive characteristics. Moreover, hydrogels with structural similarity to the skin extracellular matrix up regulate the cell material interactions for quicker skin tissue repair and more regulated stimulus response changes in the microenvironment. This current review focused on the applications of both the synthetic and natural polymers involved in the formulation of the hydrogels for the skin tissue regeneration. Furthermore, understanding the polymers simultaneously reducing the complexity of building hydrogels should be the aim of the future research in the skin tissue regenerative medicine field.

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“…Moreover, biomolecules also play an essential role in tissue repair process. Such as 5‐HMF (hydroxymethylfurfural), a bioreactor for proliferation and migration of human skin fibroblasts (HSF), which favored the wound healing 198 process, and quercitrin also demonstrated wide application including antibacterial and promoting bone cell proliferation 199 . Noteworthily, biomimetic elements‐based hydrogel will be more attractive.…”

Section: The Application Of Hydrogels In Localized Tumor Treatmentmentioning

confidence: 99%

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Tan

Huang

et al. 2020

J Biomedical Materials Res

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Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

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5-hydroxymethylfurfural-embedded poly (vinyl alcohol)/sodium alginate hybrid hydrogels accelerate wound healing

Cited by 65 publications

References 38 publications

Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation

Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation

Current Review on Polymeric Hydrogel Based

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

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