5‐Hydroxytryptamine and Other Amines in the Lungs

Junod, A.

doi:10.1002/cphy.cp030109

Cited by 8 publications

(2 citation statements)

References 71 publications

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“…It is now well established that the lungs of many species actively take up circulating biogenic amines such as serotonin and norepinephrine [7]. Animal models showed that injured endothelial cells have a decreased ability to extract norepinephrine [8].…”

Section: Reviewmentioning

confidence: 99%

Metaiodobenzylguanidine scintigraphy in pulmonary and cardiac disease

Kroonenburgh

Mostard²,

Vöö³

2010

Current Opinion in Pulmonary Medicine

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At this moment, there is no added clinical value to routinely use MIBG scanning of the lungs and the heart. This is partly due to the many unresolved questions such as what actually happens and which factors influence MIBG uptake and washout under normal physiological circumstances. But the technique, if standardized and when dynamic time acquisition is performed with the latest equipment, such as PET and single photon emission computed tomography-computed tomography (SPECT-CT), has a tremendous potential. It can unravel upto now unknown relationships between innervation, vascularization and endothelial integrity. Other diagnostic tools such as MRI and CT do not have this capacity, so the future looks bright for these new neuronal imaging techniques.

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Section: Reviewmentioning

confidence: 99%

Metaiodobenzylguanidine scintigraphy in pulmonary and cardiac disease

Kroonenburgh

Mostard²,

Vöö³

2010

Current Opinion in Pulmonary Medicine

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“…The available data on the pharmacokinetic function of the lung can be summarized as follows: 1) the compounds which concentrate most extensively in the lungs are amines with a pKa greater than 8, collectively grouped under the term of basic amines [1,2]; 2) many of these molecules are amphiphilic in nature, inasmuch as they contain a large hydrophobic group and a side chain which is protonated at physiological pH [1,2]; 3) in contrast to endogenous biogenic amines [3], a carrier-mediated, energy-dependent transport system is not involved in the pulmonary uptake of basic amines [4][5][6]; 4) no appreciable in vivo lung metabolism has been reported for most of the basic amines investigated so far [4,[6][7][8][9][10][11][12]; 5) basic amines with amphiphilic character, e.g. imipramine [8,13], methadone [9,13], chlorphentermine [13], propranolol [10], verapamil [11], and amiodarone [14], are retained in the lungs in a slowly effluxable pool.…”

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confidence: 99%

Mitochondria act as a reservoir for the basic amine HIPDM in the lung

Miniati¹,

Paci²,

Cocci³

et al. 1996

Eur Respir J

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M Mi it to oc ch ho on nd dr ri ia a a ac ct t a as s a a r re es se er rv vo oi ir r f fo or r t th he e b ba as si ic c a am mi in neIn the present study, we measured HIPDM lung kinetics and subcellular distribution in rabbits given i.v. 125 I-HIPDM. Rabbits were killed from 2 min to 5 h after injection, and the radioactivity retained in their lungs was measured. Subcellular lung fractions (nuclear, mitochondrial, lysosomal, microsomal, and postmicrosomal supernatant) were assayed for HIPDM radioactivity, protein content, and distribution of specific marker enzymes.HIPDM lung clearance in rabbits was nearly identical to that of humans. Virtually all the HIPDM radioactivity in lungs (98±1%) was associated with subcellular membranous structures. The highest HIPDM specific radioactivity was found in the mitochondrial fraction, and the subcellular distribution profile closely resembled that of the mitochondrial marker enzyme succinate cytochrome c reductase. No redistribution of HIPDM among subcellular compartments was observed over a 5 h period after injection.The data indicate that mitochondria act as reservoir for HIPDM in the lungs and contribute to the pulmonary persistence of this compound. HIPDM can be used to investigate the pulmonary uptake of basic amines in health and in lung disease.

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Assessment of Endothelial Cell Function in Health and Disease

Junod¹

1986

Update in Intensive Care and Emergency Medicine

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5‐Hydroxytryptamine and Other Amines in the Lungs

Cited by 8 publications

References 71 publications

Metaiodobenzylguanidine scintigraphy in pulmonary and cardiac disease

Metaiodobenzylguanidine scintigraphy in pulmonary and cardiac disease

Mitochondria act as a reservoir for the basic amine HIPDM in the lung

Assessment of Endothelial Cell Function in Health and Disease

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