5-Hydroxytryptamine as a sensitizer of somatic nociceptors for pain-producing substances

Nakano, Takasuke; Taira, Norio

doi:10.1016/0014-2999(76)90197-7

Cited by 15 publications

(1 citation statement)

References 7 publications

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“…It is still uncertain, however, the extent to which other inflammatory mediators found in tissue exudates may contribute to the sensitization of peripheral sensory receptor mechanisms. Keele & Armstrong (1964) demonstrated that 5-hydroxytryptamine (5-HT) has the ability to cause pain when applied to a blister base, and 5-HT was later shown to lower thresholds for chemically-induced pain in man (Sicuteri et al, 1965) and to enhance pseudoaffective responses to bradykinin in animals (Nakano & Taira, 1976). Sensory nerve endings associated with small myelinated and non-myelinated axons have been found to be activated and sensitized by 5-HT in ' Author for correspondence.…”

Section: Introductionmentioning

confidence: 99%

The effects of 5‐HT on articular sensory receptors in normal and arthritic rats

Birrell¹,

McQueen²,

Iggo³

et al. 1990

British J Pharmacology

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Section: Introductionmentioning

confidence: 99%

The effects of 5‐HT on articular sensory receptors in normal and arthritic rats

Birrell¹,

McQueen²,

Iggo³

et al. 1990

British J Pharmacology

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Kinins and the Peripheral and Central Nervous Systems

Clark¹

1979

Bradykinin, Kallidin and Kallikrein

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Metergoline elevates or reduces nociceptive thresholds in mice depending on test method and route of administration

1984

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Intrathecal injection of metergoline reduced the response latencies in the tail-flick and hot-plate tests, supporting the contention that descending 5-hydroxytryptamine (5-HT) pathways tonically inhibit pain sensitivity. Elevated latencies were, however, observed after both intraperitoneal (IP) and intracerebroventricular (ICV) injections in the hot-plate test, when hindpaw lick was used as the response criterion. These findings may indicate that supraspinal 5-HT pathways tonically increase pain responsiveness in certain test situations . Alternative hypotheses are that metergoline in supraspinal structures acts as an agonist at post-synaptic 5-HT receptors mediating antinociception, or as an antagonist at pre-synaptic 5-HT receptors. Recording of first reaction latencies on the hot-plate showed increased thresholds after IP, but not after ICV injections. This may indicate an action on 5-HT receptors in the brain not accessible after ICV injections, or that the effect is mediated by blockade of peripheral 5-HT receptors.

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5-Hydroxytryptamine as a sensitizer of somatic nociceptors for pain-producing substances

Cited by 15 publications

References 7 publications

The effects of 5‐HT on articular sensory receptors in normal and arthritic rats

The effects of 5‐HT on articular sensory receptors in normal and arthritic rats

Kinins and the Peripheral and Central Nervous Systems

Metergoline elevates or reduces nociceptive thresholds in mice depending on test method and route of administration

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