5‐Hydroxytryptamine in Platelets of Patients with Muscle Contraction Headache

Rolf, L. H.; Wiele, G.; Brune, G. G.

doi:10.1111/j.1526-4610.1981.hed2101010.x

Cited by 58 publications

(34 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, these drugs have central action, mostly on monoamine metabolism and receptors. (4) Rolb et al 10 recently demonstrated low platelet 5HT in muscle contraction headache similar to that found in migraine patients. (5) Peripheral painful stimulation either by scalp muscle contraction or vasodilation is expected to be associated with increased Morphine-like material in the CSF.…”

Section: Discussionmentioning

confidence: 71%

Transformation of Episodic Migraine Into Daily Headache: Analysis of Factors

1982

View full text Add to dashboard Cite

Seventy-six percent of patients with daily headaches were found to have a history of episodic migraine in the past, more than half of them hormone dependent headache such as menstrual migraine. Various factors possibly influencing the transformation of episodic migraine into daily headaches were analyzed in a series of 61 patients who presented with daily headaches. Abnormal personality profile, especially neuroticism including depression, excessive stress, excessive use of medications such as caffeine containing analgesics, narcotic analgesics and ergotamine, and development of hypertension were found to be significant in the transformation of episodic migraine into daily headache.The problem of daily headache is discussed. It is suggested that the majority of daily headaches are a continuum of episodic migraine, influenced and perpetuated by various factors such as neuroticism, excessive medication, stress, and development of hypertension. It is pointed out that diagnosis of tension headache under those circumstances is not justified. (Headache 22:66-68, 1982)

show abstract

Section: Discussionmentioning

confidence: 71%

Transformation of Episodic Migraine Into Daily Headache: Analysis of Factors

1982

View full text Add to dashboard Cite

show abstract

“…The finding of higher 5-HT platelet content in migraine with aura [18] was not confirmed [15, 21, 23]. Even in tension headache, platelet and plasma 5-HT are not decreased in headache-free period in comparison to control subjects [12–15, 19, 21, 28–34] (Table 2). Therefore, we can state that a hyposerotonergic status is not present in migraine and tension headache patients in the periphery.…”

Section: Peripheral Studiesmentioning

confidence: 98%

Serotonin and migraine: a reconsideration of the central theory

Panconesi¹

2008

J Headache Pain

100

View full text Add to dashboard Cite

The 5-hydroxytryptamine (5-HT) has been implicated in migraine pathophysiology for the past 50 years. A low central 5-HT disposition associated with an increase in 5-HT release during attack is the most convincing change of 5-HT metabolism implicated in migraine. Peripheral studies on plasma/platelet have not generally shown low 5-HT levels. Studies on 5-HT reactivity showed hypersensitivity, also expressed as reduced tachyphylaxis (habituation), which successively was evidenced as the most characteristic marker of an altered sensory neurotransmission. Even the gender and seasonal variations of 5-HT parameters seem to agree with a low 5-HT turnover with receptoral hypersensitivity. The interpretation of the effects of some serotonergic drugs and recent neuroimaging studies give major evidence for this cascade of events. Although the exact mechanism that links abnormal 5-HT neurotransmission to the manifestation of head pain has yet to be fully understood, a deficit on 5-HT descending pain inhibitory system is still probably today the most implicated in migraine pathophysiology. This short review focuses and discusses the alteration of peripheral and central 5-HT parameters in migraine patients.

show abstract

“…Serotonin is critically important in the pathogenesis of both migraine and tension-type headache, with peripheral serotonin levels dropping similarly during headache attacks for both migraine and tension-type headache [28,29]. Currently accepted models of chronic headache postulate that reductions in peripheral serotonin trigger a headache response.…”

Section: Estrogen and Tension-type Headachementioning

confidence: 99%

Estrogen and tension-type headache

Marcus

2001

Current Science Inc

View full text Add to dashboard Cite

The vast majority of people experience tension-type headache during their lifetimes. Boys experience tension-type headache slightly more than girls during preadolescent years. During adolescence and adult years, tension-type headache occurs more commonly in females. Tension-type headache changes in women occur in relation to gynecologic changes, including menses, pregnancy, and menopause. These changes are related to estrogen fluctuations. Estrogen fluctuations cause changes in neurochemicals important for pain signal transmission, including serotonin, gamma-aminobutyric acid, and enkephalins.

show abstract

5‐Hydroxytryptamine in Platelets of Patients with Muscle Contraction Headache

Cited by 58 publications

References 2 publications

Transformation of Episodic Migraine Into Daily Headache: Analysis of Factors

Transformation of Episodic Migraine Into Daily Headache: Analysis of Factors

Serotonin and migraine: a reconsideration of the central theory

Estrogen and tension-type headache

Contact Info

Product

Resources

About