5-hydroxytryptamine release in the anterior hypothalamic and the hippocampal areas of cholestatic rats

Terzioĝlu, Berna; Aypak, Cenk; Yananlı, Hasan Raci; Kucukibrahimoglu, E. Esra; Yurdaydın, Cihan; Gören, M. Zafer

doi:10.1016/j.lfs.2005.06.025

Cited by 4 publications

(2 citation statements)

References 27 publications

(26 reference statements)

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“…[44] Not only the serotonergic system but also the opioidergic system was demonstrated to be affected in cholestasis. [454647] Studies indicated that in BDL animals without obvious signs of infection, fever, or signs of sepsis showed activation of pro-inflammatory cytokines,[10] similar to those found in human with liver disease[48] that associated with activation of inflammatory mediators, provokes a greater behavioral impairment.…”

Section: Discussionmentioning

confidence: 88%

Cholestasis progression effects on long-term memory in bile duct ligation rats

et al. 2014

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Background:There is evidence that cognitive functions are affected by some liver diseases such as cholestasis. Bile duct ligation induces cholestasis as a result of impaired liver function and cognition. This research investigates the effect of cholestasis progression on memory function in bile duct ligation rats.Materials and Methods:Male Wistar rats were randomly divided into five groups, which include: control group for BDL-7, control group for BDL-21, sham group (underwent laparotomy without bile duct ligation), BDL-7 group (7 days after bile duct ligation), and BDL-21 group (21 days after bile duct ligation). Step-through passive avoidance test was employed to examine memory function. In all groups, short-term (7 days after foot shock) and long-term memories (21 days after foot shock) were assessed.Results:Our results showed that liver function significantly decreased with cholestasis progression (P < 0.01). Also our findings indicated BDL-21 significantly impaired acquisition time (P < 0.05). Memory retrieval impaired 7 (P < 0.05) and 21 days (P < 0.001) after foot shock in BDL-7 and BDL-21 groups, respectively.Conclusion:Based on these findings, liver function altered in cholestasis and memory (short-term and long-term memory) impaired with cholestasis progression in bile duct ligation rats. Further studies are needed to better insight the nature of progression of brain damage in cholestatic disease.

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