1998
DOI: 10.1016/s0016-5085(98)70203-3
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5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine

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Cited by 330 publications
(299 citation statements)
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“…However, although this receptor sub-type has been proposed to be identical to the 5-HT4 receptor (Grider et al, 1996), it is thought to be unrelated to the 5-HT4 receptor by others (Galligan et al, 1996;Gershon, 2004). Either way, both of these receptor types are important because each has been implicated in the initiation of peristaltic reflexes (Gershon, 2004;Grider et al, 1998;Jin et al, 1999). Since the discovery of 5-HT4 receptors in 1988, significant advances have been made in our understanding of their physiology and pharmacology.…”
Section: -Ht Receptorsmentioning
confidence: 99%
See 1 more Smart Citation
“…However, although this receptor sub-type has been proposed to be identical to the 5-HT4 receptor (Grider et al, 1996), it is thought to be unrelated to the 5-HT4 receptor by others (Galligan et al, 1996;Gershon, 2004). Either way, both of these receptor types are important because each has been implicated in the initiation of peristaltic reflexes (Gershon, 2004;Grider et al, 1998;Jin et al, 1999). Since the discovery of 5-HT4 receptors in 1988, significant advances have been made in our understanding of their physiology and pharmacology.…”
Section: -Ht Receptorsmentioning
confidence: 99%
“…The 5-HT4 receptor is pharmacologically defined by selective agonists such as SC 53116 and RS 67506, and selective antagonists such as GR 113808, SB 204070 and RS 39604 (Gale et al, 1994;Hegde et al, 1996). In the gastrointestinal tract, stimulation of 5-HT4 receptors has a pronounced effect on smooth muscle tone, mucosal electrolyte secretion, and on the peristaltic reflex (Costall et al, 1993;Grider et al, 1998;Hegde et al 1996;Jin et al, 1999;Kadowaki et al, 2002). SakuraiYamashita et al (1999SakuraiYamashita et al ( , 2000 have recently reported that 5-HT4 receptors are distributed in the human sigmoid colon, guinea pig distal colon and human rectum.…”
Section: -Ht Receptorsmentioning
confidence: 99%
“…Oral administration of buspirone improves gastric accommodation [13], accelerates interdigestive gastrointestinal motility in man [14] and increases oesophageal wave amplitude and wave progression velocity and reduces the duration and extent of lower oesophageal sphincter relaxation in healthy volunteers [15], suggesting a wide regulatory effect of this receptor on gastrointestinal motility. Other 5-HT receptors were shown to be important in the regulation of intestinal motility, as 5-HT4 and 5-HT3 are the main receptors involved in gastrointestinal peristalsis [16,17].…”
Section: Discussionmentioning
confidence: 99%
“…Many subtypes of 5-HT receptor distribute heterogeneously in gastrointestinal tissues, in prejunctional and postjunctional membranes and also in ICC, and each subtype of receptors has different actions (Liu et al, 2005). Gastrointestinal smooth muscle has a distribution of 5-HT4 receptors, and their activation produces a muscle relaxation in the rat oesophagus (Baxter et al, 1991), human intestine (Grider et al, 1998;Grider, 2003), human colon and rat ileum (Tuladhar et al, 1994). Activation of presynaptic 5-HT receptors enhances the release of acetylcholine (ACh) in the myenteric neurons (Kilbinger and Wolf, 1992;Pan and Galligan, 1994;Galligan et al, 2003), and facilitates peristaltic reflexes (Grider et al, 1998;Foxx-Orenstein et al, 1998;Grider, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…Gastrointestinal smooth muscle has a distribution of 5-HT4 receptors, and their activation produces a muscle relaxation in the rat oesophagus (Baxter et al, 1991), human intestine (Grider et al, 1998;Grider, 2003), human colon and rat ileum (Tuladhar et al, 1994). Activation of presynaptic 5-HT receptors enhances the release of acetylcholine (ACh) in the myenteric neurons (Kilbinger and Wolf, 1992;Pan and Galligan, 1994;Galligan et al, 2003), and facilitates peristaltic reflexes (Grider et al, 1998;Foxx-Orenstein et al, 1998;Grider, 2003). Two types of 5-HT receptor (5-HT1 and 5-HT4) distribute in the prejunctional membrane of myenteric cholinergic nerves, and activation of 5-HT4 receptors increases and that of 5-HT1 inhibits the release of ACh from nerves (Taniyama et al, 1991).…”
Section: Introductionmentioning
confidence: 99%