5-Hydroxytryptophan and Cisapride Stimulate Propulsive Jejunal Motility and Transit of Chyme in Dogs

Schemann, Michael; Ehrlein, H. J.

doi:10.1159/000199335

Cited by 23 publications

(6 citation statements)

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“…Our analysis of myoelectrical tracings was designed to detect events that propagated over a distance of at least 10 cm in the jejunum (at a speed ≥ 0.5 cm s –1 ) and at least 15 cm in the colon (at a speed ≥ 0.25 cm s –1 ). These parameters were chosen after a review of the literature, showing that another 5‐HT 4 receptor agonist, cisapride, stimulated propagated motor patterns in the canine and human jejunum with propagation distance and velocity that are similar to those reported in this study 36 –38 . The colonic migrating myoelectrical events observed in this study correspond to the groups of long spike bursts described in the dog colon by Fioramonti et al.…”

Section: Discussionsupporting

confidence: 76%

Intestinal motor stimulation by the 5‐HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Ponti

Crema

Moro

et al. 2001

Neurogastroenterology Motil

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5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the prokinetic effect exerted by the 5-HT4 receptor agonist ML10302 in the canine small bowel and colon in vivo; and (ii) to investigate the role of tachykininergic pathways in mediating this response. In fasting, conscious dogs, chronically fitted with electrodes and strain-gauge force transducers along the small bowel and colon, intravenous injection of ML10302 (35 microg kg-1) immediately stimulated spike activity and significantly increased propagated myoelectrical events at both intestinal levels. In the small bowel, the effects of ML10302 were unchanged by previous administration of the selective NK1 tachykinin receptor antagonist SR140333, the NK2 tachykinin receptor antagonist SR48968, or the NK3 tachykinin receptor antagonist SR142801. In the colon, all tachykinin receptor antagonists significantly inhibited stimulation of spike and mechanical activity by ML10302, without affecting ML10302-induced propagated myoelectrical events. Atropine (100 microg kg-1 i.v.) suppressed the stimulatory effect of ML10302 at both intestinal levels. In conclusion, the 5-HT4 receptor agonist ML10302 induced significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. Tachykininergic pathways are not involved in the ML10302-induced prokinesia in the small bowel, but they play an important role in mediating the colonic motor response to ML10302.

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Section: Discussionsupporting

confidence: 76%

Intestinal motor stimulation by the 5‐HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Ponti

Crema

Moro

et al. 2001

Neurogastroenterology Motil

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“…There is evidence to suggest that the substituted benzamide cisapride, which has prokinetic properties and stimulates the phasic motor activity of the gastrointestinal tract by potentiating the release of acetylcholine from postganglionic cholinergic nerves (Chey et al ., 1984; Suzuki et al ., 1985; Schemann & Ehrlein, 1986; Fujii et al ., 1988; Strombeck et al ., 1988; Schuurkes & Van Nueten, 1990), may also promote detrusor muscle motility. This action appears to be beneficial in cases of urinary retention caused by several agents and clinical studies have reported successful use of cisapride in the treatment of neuropathic bladder (Ettienne et al ., 1988), in urinary retention following prostatechtomy (Meier et al ., 1996), or even in cases of lazy bladder syndrome (Franceschetti et al ., 1997; Kroll et al ., 1998).…”

Section: Introductionmentioning

confidence: 99%

Cisapride reverses the anticholinergic effect of disopyramide on the isolated guinea‐pig urinary bladder

Koutsoviti-Papadopoulou

Nikolaidis

Batzias

et al. 2002

Vet Pharm & Therapeutics

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The present investigation aims to examine whether the prokinetic agent cisapride is able to reverse disopyramide's anticholinergic effect on the isolated guinea-pig urinary bladder. Acetylcholine, at concentrations ranging from 10(-7) to 10(-3) M, produced a stimulatory effect on the urinary bladder (pEC(50) value=5.1). Disopyramide competitively antagonized the contractile effect of acetylcholine with an ID(50)=4.4 x 10(-6) M. Although cisapride by itself had either no intrinsic contractile action or a modest effect on the urinary bladder, at concentrations ranging from 3 x 10(-7) to 10(-6) M, it significantly reversed the above inhibitory effect of disopyramide, and produced a parallel leftward shift of the concentration-response curve for acetylcholine in the presence of disopyramide. The pEC(50) values for acetylcholine in the presence of 3 x 10(-6) M and 10(-5) M disopyramide were 4.7 and 4.2, respectively, while in the presence of 10(-5) M disopyramide, after pretreatment with 5 x 10(-7) M cisapride, the pEC(50) value for acetylcholine was 4.6. It is concluded that cisapride is effective in reversing the anticholinergic activity of disopyramide on the isolated guinea-pig urinary bladder, probably by facilitating cholinergic neurotransmission.

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“…Transit studies have shown the propulsive properties of cisapride in the small intestine (7,8) and its effects on fasting and postprandial gastrointestinal motility have been well established (9 -13).…”

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confidence: 99%

Small Bowel Motility Affects Glucose Absorption in a Healthy Man

et al. 2002

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OBJECTIVE -To investigate the relationship between duodenojejunal motor activity and glucose absorption and to evaluate the effect of modification of duodenojejunal motility on glucose absorption by using the prokinetic drug cisapride.RESEARCH DESIGN AND METHODS -We examined seven healthy males, mean age 22 years, who were treated with cisapride 10 mg t.i.d. and placebo during 3 days in a randomized order, with a 2-week time interval. Duodenojejunal manometry was performed after each treatment on the morning of day 3, using an 18-lumen catheter. A liquid nutrient (3 kcal/min) was administered intraduodenally for 30 min, followed by a bolus of the glucose analog 3-Omethylglucose (3-OMG). Plasma 3-OMG concentrations were measured to assess absorption kinetics.RESULTS -The area under the 3-OMG concentration curve in the first 30 min after infusion was related to the number of antegrade propagated pressure waves (r ϭ 0.49, P Ͻ 0.05), but not to the peak concentration, time to peak, and absorption fraction. The mean amplitude of pressure waves was higher during cisapride than placebo (P Ͻ 0.05), but the reoccurrence of interdigestive motility, numbers of pressure waves, and propagated pressure waves, as well as 3-OMG absorption characteristics, were not significantly different between the two treatments. During both treatments Ͼ60% of antegrade propagated pressure waves were propagated over a very short distance (1.5 cm).CONCLUSIONS -Glucose absorption in the human small intestine is related to shorttraveling propagated intestinal contractile activity. Cisapride increases the amplitude of pressure waves, but does not affect the organization of pressure waves or the absorption of 3-OMG. Diabetes Care 25:1857-1861, 2002D igestion and absorption of nutrients are the primary functions of the small bowel. Small intestinal motor activity serves to facilitate exposure of luminal contents to the mucosal surface. Studies demonstrating the interactions between intestinal motility and nutrient absorption are few and have yielded conflicting results (1-5). This may be due to the fact that the interaction is complex and dependent on the organization of motor activity (i.e., propagated or nonpropagated) and is also affected by neuroendocrine factors.Recent studies have provided insights into the relationships between gastrointestinal motor function and glucose absorption, showing that variation in the rate of gastric emptying accounts for ϳ35% of the variance in peak blood glucose concentrations after ingestion of glucose, and that increased small intestinalpropagated activity results in the blunting of the postprandial glycemic peak (6).In the present study we used the prokinetic drug cisapride as a tool to modify small intestinal transit. Transit studies have shown the propulsive properties of cisapride in the small intestine (7,8) and its effects on fasting and postprandial gastrointestinal motility have been well established (9 -13).Several reports have shown that the spatiotemporal organization of pressure waves (i.e., propag...

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5-Hydroxytryptophan and Cisapride Stimulate Propulsive Jejunal Motility and Transit of Chyme in Dogs

Cited by 23 publications

References 11 publications

Intestinal motor stimulation by the 5‐HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Intestinal motor stimulation by the 5‐HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Cisapride reverses the anticholinergic effect of disopyramide on the isolated guinea‐pig urinary bladder

Small Bowel Motility Affects Glucose Absorption in a Healthy Man

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5-Hydroxytryptophan and Cisapride Stimulate Propulsive Jejunal Motility and Transit of Chyme in Dogs

Cited by 23 publications

References 11 publications

Intestinal motor stimulation by the 5‐HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Intestinal motor stimulation by the 5‐HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Cisapride reverses the anticholinergic effect of disopyramide on the isolated guinea‐pig urinary bladder

Small Bowel Motility Affects Glucose Absorption in a Healthy Man

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Intestinal motor stimulation by the 5‐HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Intestinal motor stimulation by the 5‐HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon