5 Hz of repetitive transcranial magnetic stimulation improves cognition and induces modifications in hippocampal neurogenesis in adult female Swiss Webster mice

Ramírez-Rodríguez, Gerardo; Juan, David Meneses-San; González-Olvera, Jorge

doi:10.1016/j.brainresbull.2022.06.001

Cited by 10 publications

(6 citation statements)

References 65 publications

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“…In animal models, rTMS has shown promising results in reversing depressive-like behaviors and modulating key neurobiological mechanisms. For example, in rodents, rTMS was found to increase neurogenesis and synaptogenesis in the hippocampus and normalize synaptic plasticity in the prefrontal cortex, as well as enhance glutamate release and signaling within both areas (Ramírez-Rodríguez et al, 2022;Qian et al, 2023). It was also demonstrated that hf-rTMS can upregulate BDNF expression in the hippocampus and prefrontal cortex (Gersner et al, 2011).…”

Section: Rtms-induced Neuroplasticitymentioning

confidence: 99%

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Dębowska,

Więdłocha,

Dębowska

et al. 2023

Front. Neurosci.

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Drug-resistant mental disorders, particularly treatment-resistant depression, pose a significant medical and social problem. To address this challenge, modern psychiatry is constantly exploring the use of novel treatment methods, including biological treatments, such as transcranial magnetic stimulation (TMS), and novel rapid-acting antidepressants, such as ketamine. While both TMS and ketamine demonstrate high effectiveness in reducing the severity of depressive symptoms, some patients still do not achieve the desired improvement. Recent literature suggests that combining these two methods may yield even stronger and longer-lasting results. This review aims to consolidate knowledge in this area and elucidate the potential mechanisms of action underlying the increased efficacy of combined treatment, which would provide a foundation for the development and optimization of future treatment protocols.

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Section: Rtms-induced Neuroplasticitymentioning

confidence: 99%

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Dębowska,

Więdłocha,

Dębowska

et al. 2023

Front. Neurosci.

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“…In the hippocampus, since the axons connecting to the dendrites of the granular cells of the DG come from the neurons in the entorhinal cortex [ 81 ], it can be speculated that rTMS promotes the presynaptic connectivity of the perforant pathway, which is involved in different memory types [ 82 , 83 ], and regulates the hippocampal activity. The increased connectivity of this pathway could be associated with the improvement in the cognitive abilities reported with the use of rTMS in rodents [ 84 ] and healthy humans [ 85 ], which are functions that have also been found to be altered in patients with depression [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Reduces Depressive-like Behaviors, Modifies Dendritic Plasticity, and Generates Global Epigenetic Changes in the Frontal Cortex and Hippocampus in a Rodent Model of Chronic Stress

Juan

Lamas

Ramírez-Rodríguez

2023

Cells

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Depression is the most common affective disorder worldwide, accounting for 4.4% of the global population, a figure that could increase in the coming decades. In depression, there exists a reduction in the availability of dendritic spines in the frontal cortex (FC) and hippocampus (Hp). In addition, histone modification and DNA methylation are also dysregulated epigenetic mechanisms in depression. Repetitive transcranial magnetic stimulation (rTMS) is a technique that is used to treat depression. However, the epigenetic mechanisms of its therapeutic effect are still not known. Therefore, in this study, we evaluated the antidepressant effect of 5 Hz rTMS and examined its effect on dendritic remodeling, immunoreactivity of synapse proteins, histone modification, and DNA methylation in the FC and Hp in a model of chronic mild stress. Our data indicated that stress generated depressive-like behaviors and that rTMS reverses this effect, romotes the formation of dendritic spines, and favors the presynaptic connection in the FC and DG (dentate gyrus), in addition to increasing histone H3 trimethylation and DNA methylation. These results suggest that the antidepressant effect of rTMS is associated with dendritic remodeling, which is probably regulated by epigenetic mechanisms. These data are a first approximation of the impact of rTMS at the epigenetic level in the context of depression. Therefore, it is necessary to analyze in future studies as to which genes are regulated by these mechanisms, and how they are associated with the neuroplastic modifications promoted by rTMS.

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“…Adult hippocampal neurogenesis (AHN) plays an important role in learning and memory processing, which occur in the process of human physiological and pathological aging, mainly including the proliferation, differentiation, survival, and maturation of neonatal neurons 120 . The application of different rTMS protocols could effectively promote AHN and elevate the number of mature and active neurons in various animal models 121–123 . In healthy animals, rTMS increases AHN in the dentate gyrus which contributes to cognitive improvement 121 .…”

Section: Potential Mechanisms Underlying the Neuroprotection Of Rtms ...mentioning

confidence: 99%

“…[121][122][123] In healthy animals, rTMS increases AHN in the dentate gyrus which contributes to cognitive improvement. 121 Moreover, rTMS can promote the proliferation of hippocampal neural stem cells and increase the dendric complexity and activity of neonatal neurons in depression and ischemic stroke animal models. 122,123 Given the crucial role of AHN in AD pathogenesis, it is important to explore the effect of rTMS on the AHN in AD in the future.…”

Section: The Cellular Mechanism Of Rtms Treatment In Admentioning

confidence: 99%

Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms

Zhu,

Liao,

Gao

et al. 2024

Neuroprotection

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Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions, for which an effective treatment is currently unavailable. Repetitive transcranial magnetic stimulation (rTMS), a well‐established noninvasive brain stimulation method, is utilized in clinical settings to address various neuropsychiatric conditions, such as depression, neuropathic pain, and poststroke dysfunction. Increasing evidence suggests that rTMS may enhance cognitive abilities in individuals with AD. However, its optimal therapeutic protocols and precise mechanisms are currently unknown, impeding its clinical implementation. In the present review, we aimed to summarize and discuss the efficacy‐related parameters in rTMS treatment, encompassing stimulus frequency, stimulus pattern, stimulus intensity, and the configuration of the stimulus coil. Furthermore, we reviewed promising rTMS therapeutic protocols involving various combinations of these factors, that were examined in clinical studies. Based on our analysis, we propose that a multisite high‐frequency rTMS (HF‐rTMS) regimen has value in AD therapy, and that promising single‐site protocols, such as HF‐rTMS, applied over the left dorsolateral prefrontal cortex, precuneus, or cerebellum are required to be validated in larger clinical studies. Lastly, we provide a comprehensive review of the potential mechanisms underlying the neuroprotective effects of rTMS on cognition in AD in terms of brain network modulation as well as cellular and molecular reactions. In conclusion, the interaction of diverse mechanisms may be responsible for the total therapeutic effect of rTMS on AD. This review provides theoretical and practical evidence for the future clinical application and scientific research of rTMS in AD.

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5 Hz of repetitive transcranial magnetic stimulation improves cognition and induces modifications in hippocampal neurogenesis in adult female Swiss Webster mice

Cited by 10 publications

References 65 publications

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Repetitive Transcranial Magnetic Stimulation Reduces Depressive-like Behaviors, Modifies Dendritic Plasticity, and Generates Global Epigenetic Changes in the Frontal Cortex and Hippocampus in a Rodent Model of Chronic Stress

Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms

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5 Hz of repetitive transcranial magnetic stimulation improves cognition and induces modifications in hippocampal neurogenesis in adult female Swiss Webster mice

Cited by 10 publications

References 65 publications

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Repetitive Transcranial Magnetic Stimulation Reduces Depressive-like Behaviors, Modifies Dendritic Plasticity, and Generates Global Epigenetic Changes in the Frontal Cortex and Hippocampus in a Rodent Model of Chronic Stress

Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms

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5 Hz of repetitive transcranial magnetic stimulation improves cognition and induces modifications in hippocampal neurogenesis in adult female Swiss Webster mice